First report on cutaneous infectious granuloma caused by Schizophyllum commune

Abstract

BackgroundSchizophyllum commune, a basidiomycetous fungus, is a common invader of rotten wood. This fungus rarely causes mycotic disease in humans, especially cutaneous infection. In this paper, we describe the first case of cutaneous granuloma caused by S. commune in a Chinese woman.Case presentationA 25-year-old female with a two-year history of erythema, papules, nodules, and scales on her sole of left foot was presented to our outpatient center. Samples were obtained by the scraping of lesion and for light microscopy. Hyphae were observed by microscopic examination. We carried out a skin tissue biopsy, which showed multiple granulomatous nodules. Biopsy specimens were also inoculated onto media. After being cultured on SDA at 27 °C for 7 days, spreading-woolly-white colonies grew on the inoculation sites of media containing chloramphenicol only and there,s no other colonies grew. S. commune was identified by morphology methods, biochemical tests, and PCR sequencing. Pathological findings also aided in diagnosing cutaneous fungal granuloma. Oral itraconazole was applied. After 1 month of therapy, rashes on her left foot and pain were improved.ConclusionWe describe the first case of cutaneous granuloma caused by Schizophyllum commune, which illustrates the importance of recognizing uncommon pathogenic fungal infections.

Pulmonary infection of Schizophyllum commune diagnosed by metagenomic next- generation sequencing: A case report

“…[4] Pulmonary imaging and clinical laboratory examination usually lack specificity. According to the vitro post infection experiment of mice, [5] the mycology and laboratory research progress of Schizophyllum commune speculated that the pathogenesis may induce serious local inflammatory reaction and produces inflammatory suppurative granulomatous lesions and fibrosis. Morphologically, Schizophyllum commune with haploid strain cannot be distinguished from Aspergillus and other fungi with transparent separated hyphae.…”

Molecular epidemiology of clinical filamentous fungi in Qatar beyond Aspergillus and Fusarium with notes on the rare species

“… 163 Mycoses due to S. commune is mostly prevalent in Japan compared with other parts of the world. 163 Ulceration of the palate, 164 brain abscess, 160 , 165 otitis externa, 166 , 167 meningitis, 168 pneumonia, 169 cutaneous granuloma, 170 and onychomycosis 171 caused by S. commune have also been reported. In the current study, we report the first case of S. commune from Qatar from a 55 year old female with rhinosinusitis.…”

Analysis of Airborne Fungal Communities on Pedestrian Bridges in Urban Environments

“…The genus Schizophyllum , showing the third highest abundance in our analyzed environments, is known mostly as a saprotrophic genus, commonly growing on wood and fallen leaves [ 60 , 61 ]. Schizophyllum commune, which accounted for 5.26% of the total isolated strains in this study, was recently found to cause mycotic disease in people on a rare basis, especially via cutaneous infection [ 62 ]. Although this fungal species is not commonly considered as pathogenic to humans, being mostly regarded as a medicinal mushroom [ 63 ], S. commune was indicated as a possible cause of pulmonary basidiomycosis by Unno et al [ 64 ], while inhalation of S. commune spores has been recently linked to allergic bronchopulmonary mycosis (ABPM) or allergy-related bronchopulmonary infections and sinusitis [ 65 , 66 ].…”