First reported case of transfusion‐transmitted Ross River virus infection

Hoad, Veronica C.; Speers, David; Keller, A. J.; Dowse, Gary K.; Seed, Clive R.; Lindsay, M.D.; Faddy, Helen M.; Pink, Joanne

doi:10.5694/mja14.01522

Cited by 52 publications

(61 citation statements)

References 9 publications

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“…The level of viral RNA in the Puerto Rico donor from with the highest titer, 9.1 × 10 7 copies/mL, who remained asymptomatic, is comparable to the median viral titer observed previously in symptomatic CHIKV patients (5.6 × 10 5 PFU/mL, or ≈5.6 × 10 7 copies/mL) ( 3 ). No cases of CHIKV-associated TTI have been confirmed to date, although potential transmission by that route of related alphaviruses such as RRV has been documented ( 4 ). Nevertheless, our results indicate that high-titer asymptomatic CHIKV infections, if transmissible by transfusion, can readily elude routine screening based solely on postdonation reporting of febrile illness.…”

Section: Discussionmentioning

confidence: 99%

“…However, several factors raise concern about possible CHIKV TTI, including a 10%–25% asymptomatic infection rate and high viremic titers in asymptomatic persons ( 3 ). Recently, a probable TTI case from Ross River virus (RRV), an alphavirus related to CHIKV, was reported in a person who had received RRV-positive donor blood, and a clinically compatible illness developed with subsequent seroconversion ( 4 ). …”

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confidence: 99%

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Genomic Assays for Identification of Chikungunya Virus in Blood Donors, Puerto Rico, 2014

Chiu¹,

Brès²,

Yu³

et al. 2015

Emerg. Infect. Dis.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Genomic Assays for Identification of Chikungunya Virus in Blood Donors, Puerto Rico, 2014

Chiu¹,

Brès²,

Yu³

et al. 2015

Emerg. Infect. Dis.

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“…Arbovirus transmission by transfusion of blood products has been documented for DENV (75,76), WNV (77,309), and RRV (78). Given its epidemiology, the possibility of ZIKV transmission via transfusion should be considered as well (310,311).…”

Section: Non-vector-borne Transmissionmentioning

confidence: 99%

“…Nonvector arbovirus transmission has been reported to occur directly between vertebrates (64, 65), from mother to child (66)(67)(68)(69)(70)(71), nosocomially (72)(73)(74), by transfusion (75)(76)(77)(78), via bone marrow (79) or organ (80) transplantation, and sexually (81).…”

Section: Vectors and Transmissionmentioning

confidence: 99%

Zika Virus

2016

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SUMMARYZika virus (ZIKV) is an arthropod-borne virus (arbovirus) in the genusFlavivirusand the familyFlaviviridae. ZIKV was first isolated from a nonhuman primate in 1947 and from mosquitoes in 1948 in Africa, and ZIKV infections in humans were sporadic for half a century before emerging in the Pacific and the Americas. ZIKV is usually transmitted by the bite of infected mosquitoes. The clinical presentation of Zika fever is nonspecific and can be misdiagnosed as other infectious diseases, especially those due to arboviruses such as dengue and chikungunya. ZIKV infection was associated with only mild illness prior to the large French Polynesian outbreak in 2013 and 2014, when severe neurological complications were reported, and the emergence in Brazil of a dramatic increase in severe congenital malformations (microcephaly) suspected to be associated with ZIKV. Laboratory diagnosis of Zika fever relies on virus isolation or detection of ZIKV-specific RNA. Serological diagnosis is complicated by cross-reactivity among members of theFlavivirusgenus. The adaptation of ZIKV to an urban cycle involving humans and domestic mosquito vectors in tropical areas where dengue is endemic suggests that the incidence of ZIKV infections may be underestimated. There is a high potential for ZIKV emergence in urban centers in the tropics that are infested with competent mosquito vectors such asAedes aegyptiandAedes albopictus.

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“…The most ordinary approach of biological transmission is infection during a viremic blood meal and injection of infectious saliva during blood feeding (horizontal transmission). Non-vector arbovirus transmission has been reported to occur straight between vertebrates [27][28] , from mother to child [29][30][31][32][33][34] , nosocomially [35][36][37] , by transfusion [38][39][40][41] , via bone marrow [42] or organ transplantation, and sexually. Management commitment and employee involvement-Essential to implement effective infection management programs selected personnel should review, update and act on all steerage, as well as normal operational procedures and exposure management plans, and should communicate those policies and practices to any or all employees.…”

Section: Classification and Phylogeny Of Zikvmentioning

confidence: 99%

Zika Virus: A Review

Siddiqui¹,

Negi²,

Singh³

et al. 2017

IJLSSR

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ABSTRACT-Zika virus is a mosquito transmitted flavivirus belongs to family Flaviviridae, which became the focus of an ongoing pandemic and public health emergency all around the world. Zika virus (ZIKV) has 2 lineages: African and Asian. Mosquito-borne flaviviruses are thought to initially replicate in dendritic cells and then spread to lymph and therefore the blood stream. Risk for infection through blood transfusion, sexual practices, and perinatal transmission exists. The potential routes of perinatal transmission are all over delivery, breastfeeding and by close contact between the mother and newborn baby. ZIKV is often misdiagnosed with other infection like Dengue and Chikungunya because of similar clinical manifestation. The association between these conditions with Zika virus infection is still not confirmed and is under assessment. Since ZIKV has neither an effective treatment nor a vaccine is available, therefore the public health authority focuses on preventing infection, particularly in pregnant women and virus transmitted region. Zika infections in adults may result rarely in Guillain-Barre syndrome. World Health Organization and different health officers are working on the development of new projects and mosquito control methods to cope up with infection as there's very less literature present on the pathologic process of the Zika virus to help interpret the clinical disease spectrum and target treatments to minimize or prevent infection. WHO/PAHO encourages the countries to set up and retain Zika virus infection detection, clinical management and community assertion strategies to decrease transmission of the virus. This review describes the current understanding of the epidemiology, transmission, clinical characteristics, and diagnosis of Zika virus infection, as well as the future outlook with regard to this disease.

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First reported case of transfusion‐transmitted Ross River virus infection

Cited by 52 publications

References 9 publications

Genomic Assays for Identification of Chikungunya Virus in Blood Donors, Puerto Rico, 2014

Genomic Assays for Identification of Chikungunya Virus in Blood Donors, Puerto Rico, 2014

Zika Virus

Zika Virus: A Review

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