First results from the UK COVID-19 Serology in Oncology Staff Study (CSOS)

Favara, David M.; Cooke, Anthony; Döffinger, Rainer; Houghton, S. B.; Budriunaite, Ieva; Bossingham, Sophie; McAdam, Karen; Corrie, Pippa; Ainsworth, Nicola

doi:10.1101/2020.06.22.20136838

Cited by 7 publications

(8 citation statements)

References 15 publications

(25 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…• Several studies report an association between COVID-19 symptoms and: seropositivity [87][88][89], higher titres of IgG [29,79,90] and anti-RBD and anti-S antibodies [91]. • Two studies reported that asymptomatic healthcare workers did develop antibodies [92,93].…”

Section: Symptom Profilementioning

confidence: 99%

Antibody response to SARS-CoV-2 infection in humans: A systematic review

et al. 2020

View full text Add to dashboard Cite

Background Progress in characterising the humoral immune response to Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) has been rapid but areas of uncertainty persist. Assessment of the full range of evidence generated to date to understand the characteristics of the antibody response, its dynamics over time, its determinants and the immunity it confers will have a range of clinical and policy implications for this novel pathogen. This review comprehensively evaluated evidence describing the antibody response to SARS-CoV-2 published from 01/01/2020-26/06/2020. Methods Systematic review. Keyword-structured searches were carried out in MEDLINE, Embase and COVID-19 Primer. Articles were independently screened on title, abstract and full text by two researchers, with arbitration of disagreements. Data were double-extracted into a pre-designed template, and studies critically appraised using a modified version of the Public Health Ontario Meta-tool for Quality Appraisal of Public Health Evidence (MetaQAT) tool, with resolution of disagreements by consensus. Findings were narratively synthesised. Results 150 papers were included. Most studies (113 or 75%) were observational in design, were based wholly or primarily on data from hospitalised patients (108, 72%) and had important methodological limitations. Few considered mild or asymptomatic infection. Antibody dynamics were well described in the acute phase, up to around three months from disease onset, but the picture regarding correlates of the antibody response was inconsistent. IgM was consistently detected before IgG in included studies, peaking at weeks two to five and declining over a further three to five weeks post-symptom onset depending on the patient group; IgG peaked around weeks three to seven post-symptom onset then plateaued, generally persisting for at least eight weeks. Neutralising antibodies were detectable within seven to 15 days following disease onset, with levels increasing until days 14–22 before levelling and then decreasing, but titres were lower in those with asymptomatic or clinically mild disease. Specific and potent neutralising antibodies have been isolated from convalescent plasma. Cross-reactivity but limited cross-neutralisation with other human coronaviridae was reported. Evidence for protective immunity in vivo was limited to small, short-term animal studies, showing promising initial results in the immediate recovery phase. Conclusions Literature on antibody responses to SARS-CoV-2 is of variable quality with considerable heterogeneity of methods, study participants, outcomes measured and assays used. Although acute phase antibody dynamics are well described, longer-term patterns are much less well evidenced. Comprehensive assessment of the role of demographic characteristics and disease severity on antibody responses is needed. Initial findings of low neutralising antibody titres and possible waning of titres over time may have implications for sero-surveillance and disease control policy, although further evidence is needed. The detection of potent neutralising antibodies in convalescent plasma is important in the context of development of therapeutics and vaccines. Due to limitations with the existing evidence base, large, cross-national cohort studies using appropriate statistical analysis and standardised serological assays and clinical classifications should be prioritised.

show abstract

Section: Symptom Profilementioning

confidence: 99%

Antibody response to SARS-CoV-2 infection in humans: A systematic review

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Three studies report an association between COVID-19 symptoms and seropositivity, [156][157][158] and with higher titres of IgG, 29,159 IgA, 159 and anti-RBD and anti-S antibodies. 160…”

mentioning

confidence: 99%

Antibody response to SARS-CoV-2 infection in humans: a systematic review

Post

Eddy

Huntley

et al. 2020

Preprint

View full text Add to dashboard Cite

Introduction Progress in characterising the humoral immune response to Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) has been rapid but areas of uncertainty persist. This review comprehensively evaluated evidence describing the antibody response to SARS-CoV-2 published from 01/01/2020-26/06/2020. Methods Systematic review. Keyword-structured searches were carried out in MEDLINE, Embase and COVID-19 Primer. Articles were independently screened on title, abstract and full text by two researchers, with arbitration of disagreements. Data were double-extracted into a pre-designed template, and studies critically appraised using a modified version of the MetaQAT tool, with resolution of disagreements by consensus. Findings were narratively synthesised. Results 150 papers were included. Most studies (75%) were observational in design, and included papers were generally of moderate quality based on hospitalised patients. Few considered mild or asymptomatic infection. Antibody dynamics were well described in the acute phase, and up to around 3 months from disease onset, although inconsistencies remain concerning clinical correlates. Development of neutralising antibodies following SARS-CoV-2 infection is typical, although titres may be low. Specific and potent neutralising antibodies have been isolated from convalescent plasma. Cross reactivity but limited cross neutralisation occurs with other HCoVs. Evidence for protective immunity in vivo is limited to small, short-term animal studies, which show promising initial results in the immediate recovery phase. Interpretation Published literature on immune responses to SARS-CoV-2 is of variable quality with considerable heterogeneity with regard to methods, study participants, outcomes measured and assays used. Antibody dynamics have been evaluated thoroughly in the acute phase but longer follow up and a comprehensive assessment of the role of demographic characteristics and disease severity is needed. The role of protective neutralising antibodies is emerging, with implications for therapeutics and vaccines. Large, cross-national cohort studies using appropriate statistical analysis and standardised serological assays and clinical classifications should be prioritised.

show abstract

“… Representativeness Is the data representative for HCW worldwide? Abdelmoniem et al [ 23 ] Low RoB Lacking representativeness Al-Zoubi et al [ 24 ] Low RoB Lacking representativeness Armin et al [ 25 ] Low RoB Lacking representativeness Brown et al [ 26 ] Low RoB Potentially for hospital staff, wide range of diverse job roles Campbell et al [ 27 ] Low RoB Lacking representativeness Cavicchiolo et al [ 28 ] Low RoB Lacking representativeness Demmer et al [ 29 ] Low RoB Lacking representativeness Dillner et al [ 30 ] Low RoB Potentially for hospital staff, high case number Fakhim et al [ 31 ] Low RoB Lacking representativeness Favara et al [ 32 ] Low RoB Lacking representativeness Ferreira et al [ 33 ] Low RoB Potentially for hospital staff, high case number Fusco et al [ 34 ] Low RoB Lacking representativeness Guery et al [ 35 ] Low RoB Lacking representativeness Halbrook et al [ <...…”

Section: Resultsmentioning

confidence: 99%

The role of routine SARS-CoV-2 screening of healthcare-workers in acute care hospitals in 2020: a systematic review and meta-analysis

et al. 2022

View full text Add to dashboard Cite

Background Healthcare workers (HCW) are at increased risk of infection with SARS-CoV-2. Vulnerable patient populations in particular must be protected, and clinics should not become transmission hotspots to avoid delaying medical treatments independent of COVID. Because asymptomatic transmission has been described, routine screening of asymptomatic HCW would potentially be able to interrupt chains of infection through early detection. Methods A systematic search was conducted in the Cochrane COVID-19 Study Register, Web of Science and WHO COVID‐19 Global literature on coronavirus with regard to non-incident related testing of healthcare workers using polymerase chain reaction on May 4th 2021. Studies since January 2020 were included. An assessment of risk of bias and representativeness was performed. Results The search identified 39 studies with heterogeneous designs. Data collection of the included studies took place from January to August 2020. The studies were conducted worldwide and the sample size of the included HCW ranged from 70 to 9449 participants. In total, 1000 of 51,700 (1.9%) asymptomatic HCW were tested positive for SARS-CoV-2 using PCR testing. The proportion of positive test results ranged between 0 and 14.3%. No study reported on HCW-screening related reductions in infected person-days. Discussion and conclusions The heterogeneous proportions might be explained by different regional incidences, lock-downs, and pre-analytical pitfalls that reduce the sensitivity of the nasopharyngeal swab. The very high prevalence in some studies indicates that screening HCW for SARS-CoV-2 may be important particularly in geographical regions and pandemic periods with a high-incidence. With low numbers and an increasing rate of vaccinated HCW, a strict cost–benefit consideration must be made, especially in times of low incidences. Since we found no studies that reported on HCW-screening related reductions in infected person-days, re-evaluation should be done when these are available.

show abstract

First results from the UK COVID-19 Serology in Oncology Staff Study (CSOS)

Cited by 7 publications

References 15 publications

Antibody response to SARS-CoV-2 infection in humans: A systematic review

Antibody response to SARS-CoV-2 infection in humans: A systematic review

Antibody response to SARS-CoV-2 infection in humans: a systematic review

The role of routine SARS-CoV-2 screening of healthcare-workers in acute care hospitals in 2020: a systematic review and meta-analysis

Contact Info

Product

Resources

About