First Steps toward Noninvasive Intraocular Pressure Monitoring with a Sensing Contact Lens

Abstract

The sensing contact lens shows the potential for continuously monitoring IOP in enucleated porcine eyes. The ultimate step will be the validation of the system and the reproducibility of results in humans. The device is placed in the same way as a corrective contact lens, no anesthesia is required, and vision remains almost unimpaired. This device would allow minimally invasive IOP monitoring over prolonged periods, regardless of the patient's position and activity, thus opening up new diagnostic and therapeutic methods for the management of glaucoma.

Nanomedicine and its role in Ophthalmology

“…The recorded intraocular pressures were either flat, fluctuating or that had spikes. 51,52,53 Natarajan JV et al prepared sustain released latanoprost and successfully tested in vitro and also observed sustained efficacy of lowering the intraocular pressure for 120 days in a diseased nonhuman primate model. The carrier for latanoprost delivery was nanosized unilamellar vesicle.…”

Tonometry – Past, Present and Future

“…This method of operation made the system unsuitable for the continuous measurement of IOP and dependent on the patient's ability to activate it. The only system that is expected to appear on the market soon is the Triggerfish designed by Leonardi et al (2004) and developed by Sensimed, Switzerland, Figure 16c. The system incorporates a contact lens fitted with a circumferential strain gauge that detects IOP changes.…”

“…The device has been recently validated in a clinical study (Mansouri & Shaarawy, 2011). (Waters et al, 1990) (b) A corneamounted IOP sensor activated by a plunger (Fleischman et al, 2007) (c) A contact lens with IOP measurement sensor and an unobstructed visual zone (Leonardi et al, 2004) …”

A microscale optical implant for continuous in vivo monitoring of intraocular pressure

“…Recently developed contact-lens-based IOP sensors also provide indirect IOP measurements. They track changes in the corneal scleral angle as a surrogate measure and provide relative IOP trends in mV rather than mm Hg [31][32][33][34][35][36][37][38][39][40] . Such measurements can only be obtained for up to 24 h because of side complications that accompany long-term use [41][42][43] .…”