First synthesis and antiprotozoal activities of divinyl sulfone-modified carbohydrates

Dapson in Heterocyclic Chemistry, Part V: Synthesis, Molecular Docking and Anticancer Activity of Some Novel Sulfonylbiscompounds Carrying Biologically Active Dihydropyridine, Dihydroisoquinoline, 1,3-Dithiolan, 1,3-Dithian, Acrylamide, Pyrazole, Pyrazolopyrimidine and Benzochromenemoieties

“…Infra-red spectra were recorded in KBr discs using IR-470 Shimadzu spectrometer (Shimadzu, Tokyo, Japan). NMR spectra (in DMSO-d 6 ) were recorded on Bruker AC-300 Ultra Shield NMR spectrometer (Bruker, Flawil, Switzerland, δ ppm) at 300 MHz using tetramethylsilane (TMS) as internal standard and peak multiplicities are designed as follows: s, singlet; d, doublet; t, triplet; m, multiplet. Elemental analyses were performed on Carlo Erba 1108 Elemental Analyzer (Heraeus, Hanau, Germany).…”

“…[1][2][3][4][5][6][7][8] Also, diphenylsulfones and bisheterocyclic compounds are reported to have a broad spectrum of biological activities. Some are endowed with antitumor, 9) or antifungal properties.…”

“…(SO 2 ). 1 H-NMR spectrum in (DMSO-d 6 ) of 2 exhibited signals at 4.0 ppm due to CH 2 group and 7.4-7.9 ppm corresponding to aromatic protons. It is well known that many pyridine-2-one derivatives exhibited diverse biological activity such as anticancer activity.…”

Versatile poly(maltose) micro/nanoparticles with tunable surface functionality as a biomaterial

“…[31][32][33][34] Divinyl sulfone (DVS) is an important molecule that widely employed in functionalization of biological molecules such as peptides, proteins, carbohydrate, and so on via Michael's addition reaction. [35][36][37][38] Moreover, it was reported that DVS functionalization render appealing features, for example, anti-inflammatory, and inhibition of tumor cell growth. [36][37][38] Furthermore, it was also reported that DVS functional group utilization is limited on carbohydrates because of inadequacy of strategies to attract the sulfone group to chiral carbohydrates.…”

A facile regio- and stereoselective synthesis of trans-ethyl 5-aroyl-4-aryl-2-[(arylsulfonyl)methyl]-4,5-dihydrofuran-3-carboxylates

“…15 Sulfones appended to furan moiety also show important biological activities. For example, functionalized vinyl dihydrofuryl sulfones 4 and tetrahydrofuryl sulfones 5 show antiprotozoal 16 and antimycobacterial activity 17 respectively. Consequently, in the present work, we report the regio-and stereoselective synthesis of highly functionalized biologically relevant dihydrofurans bearing arylsulfonyl moiety 6.…”