First synthesis and structural report on selenophen-2-yl containing pnictogens: Biological activities of tris(selenophen-2-yl)stibine

Sharma, Pankaj; Rosas, N.; Cabrera, Armando; Toscano, Rubén A.; Silva, Maria de Jesus; Pérez, Diego; Velasco, Luis; Pérez, Javier; Gutierez, Rene

doi:10.1016/j.jorganchem.2005.03.047

Cited by 18 publications

(5 citation statements)

References 30 publications

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“…In the same manner the average Sb-C (ferrocenyl) bond distance found in compound 4 is 2.131(6) Å is slightly longer than the Sb-C (ferrocenyl) bond distance observed in stibine (3). In compound 2, geometry around antimony is pyramidal and the average C-Sb-C angle is 96.02(2), which is not very different from the bond angles found in other tertiary stibines [21][22][23][24]. The vinyl group is directed toward the diphenylstibino substituent while remaining parallel with the parent cyclopentadienyl ring, which allows an efficient conjugation that is demonstrated by the angles by C@C bond and the Cp1 planes [À11.51(6)°].…”

Section: Resultsmentioning

confidence: 95%

Formation of (vinyl-ferrocenyl)stibines involving β-elimination: Hypervalent Sb–N bonding

Vázquez

Sharma

Cabrera

et al. 2007

Journal of Organometallic Chemistry

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Section: Resultsmentioning

confidence: 95%

Formation of (vinyl-ferrocenyl)stibines involving β-elimination: Hypervalent Sb–N bonding

Vázquez

Sharma

Cabrera

et al. 2007

Journal of Organometallic Chemistry

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“…Our group [50,51] has published reports on the antitumoral activity of organostibine containing heterocycles; for example, selenophenyl or substituted thienyl ring (Figure 7). The compound tris(2-selenophenyl)stibine and tris(3-methyl-2-thienyl)stibine showed a significant selectivity (>85%) for carcinogenic cell K and U growth inhibition.…”

Section: Trivalent Antimony Compoundsmentioning

confidence: 99%

Perspectives of antimony compounds in oncology

Sharma¹,

Pérez²,

Cabrera³

et al. 2008

Acta Pharmacologica Sinica

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Antimony, a natural element that has been used as a drug for over more than 100 years, has remarkable therapeutic efficacy in patients with acute promyelocytic leukemia. This review focuses on recent advances in developing antimony anticancer agents with an emphasis on antimony coordination complexes, Sb (III) and Sb (V). These complexes, which include many organometallic complexes, may provide a broader spectrum of antitumoral activity. They were compared with classical platinum anticancer drugs. The review covers the literature data published up to 2007. A number of antimonials with different antitumoral activities are known and have diverse applications, even though little research has been done on their possibilities. It might be feasible to develop more specific and effective inhibitors for phosphatase-targeted, anticancer therapeutics through the screening of sodium stibogluconate (SSG) and potassium antimonyltartrate-related compounds, which are comprised of antimony conjugated to different organic moieties. For example, SSG appears to be a better inhibitor than suramin which is a compound known for its antineoplastic activity against several types of cancers.

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“…Considering the vast number of ferrocene ligands and the unique stereoelectronic properties of the ferrocene framework and in view of the nonexistence of ferrocene bonded antimony in the literature and our interest in stibine ligands [13][14][15][16][17], some novel diphenylstibines containing ferrocenyl group having pendant arm [2-(Me 2 NCHR)] on ferrocenyl ring were synthesized and their structures were determined.…”

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confidence: 99%