First synthesis of 7α- and 7β-amino-DHEA, dehydroepiandrosterone (DHEA) analogues and preliminary evaluation of their cytotoxicity on Leydig cells and TM4 Sertoli cells

Dehydroepiandrosterone and 7-oxo-dehydroepiandrosterone in male reproductive health: Implications of differential regulation of human Sertoli cells metabolic profile

“…It was previously reported that DHEA (up to 70 mM) is not toxic to mice SCs [55]. Our data showed similar results on hSCS.…”

N‐substituted Piperazinopyridylsteroid Derivatives as Abiraterone Analogues Inhibit Growth and Induce Pro‐apoptosis in Human Hormone‐independent Prostate Cancer Cell Lines

“…The promising results obtained by us and other authors fully deserve the necessity of developing these types of molecules. In continuation of our previous work in developing new biologically active modified steroids , we choose substituted nitrogenous heterocycles as piperazine derivatives that are a pharmacologically interesting class of heterocycles . Additionally, we have previously reported a series of piperazinyl bile acid derivatives that showed promising antitumour activities .…”

Chemical and biochemical approaches to the production of 7-hydroxylated C19-steroids

“…The chemical synthesis of the 7 β -hydroxylated epimer was described in a patent in 2009 [13] . Starting from the known C-17 protected enone ( 5 ) [14] , a stereoselective reduction using Luche ' s reagent [15] gave the allylic β -alcohol ( 6 ). C-17 deprotection and saponifi cation of the C-3 acetate provided 7 β -hydroxy-DHEA ( 7 ) in 60 % overall yield.…”