First Synthesis of Furo[3,4‐c]coumarins.

Abstract

OMe CHO R O O O R' Me R 3 steps Various 1,3-dimethyl and 1-methyl-3-phenylfuro[3,4-c]coumarins (5a-h and 6a-h) have been synthesized by demethylation cyclization of the respective 3-aryl-4-ethoxycarbonyl furans (3a-h and 4a-h). These ethoxycarbonyl furans were prepared by reacting appropriate 1-aryl-2-nitro-prop-1-ene (1a-h) with ethyl acetoacetate or ethyl benzoylacetate under Nef reaction condition.

Synthetic Routes to Coumarin(Benzopyrone)-Fused Five-Membered Aromatic Heterocycles Built on the α-Pyrone Moiety. Part 1: Five-Membered Aromatic Rings with One Heteroatom

“…In the literature, a large number of reports described the synthesis of 4 H -furo[2,3- c ] and 4 H -furo[3,2- c ]benzopyran-4-ones, while synthesis of the 4 H -furo[3,4- c ]benzopyran-4-one was reported by only one study, that of Brahmbhatt and his coworkers [ 32 ]. The first 4 H -furo[3,4- c ]benzopyran-4-ones ( 10) was synthesized by the demethylation–cyclization reaction of intermediates, 3-substituted-4-ethoxycarbonyl furans 9 ( Scheme 3 ).…”

Synthesis and characterization of some novel coumarin based various 2-aryl-pyrido [3,2-c] coumarins

“…The pyrido [2,3-c]coumarin skeleton constitutes the backbone of Santiagonamine [8] . This alkaloid has been isolated from Berberis Darvinii (Berberidaceae) and has shown interesting wound healing properties [9][10][11][12][13][14][15] . Thus pyrido fused coumarins become an important class of heterocyclic fused coumarin derivatives and therefore brief literature account on various synthetic methods available for pyrido fused coumarins are presented in research work…”

Synthesis, Characterization and Antimicrobial Screening of Coumarin Copolymers

“…The extract containing coumarin related heterocycles which were employed as herbal remedies in early days, have now been extensively studied for their biological activities 3 . The incorporation group as a fused component into parent coumarin alters the property of parent coumarin and converts it into a more useful product 4 natural coumarins are known to have antidiabetic activity 5 , anabolic antioxidant and hepato protective activities 6 . Substituted coumarins derivatives have been reported to have variety of biological activities.…”