First synthesis of pyrene-functionalized silatranes for mechanistic insights into their potential anti-parasitic and anti-oxidation activities

Abstract

The known silatranes have attached substituents such as hydrogen, organyl, organoxy, aminoalkyl, thioorganyl, acyloxy, halogen, pseudohalogen, and other groups; however, their functionalization with any polycyclic aromatic hydrocarbon substituent is not recognized; this creates a niche in silatrane chemistry.

3-Aminopropylsilatrane and Its Derivatives: A Variety of Applications

“…The studies showed that both compounds were capable to act against Giardia lamblia and Trichomonas vaginalis . Moreover, silatrane ( 22 ) had a better effect on T. vaginalis than the standard drugs, for example, Metronidazole IC 50 10 μM; silatrane ( 22 ) IC 50 1.75 μM [ 56 ].…”

“…The performed investigations [ 56 , 57 , 58 ] demonstrate the importance of the synthesis and application of APS-containing multicomponent antiparasitic agents.…”

A dual response UV-vis and fluorescence receptor based on acetylenic-indole conjoined silatrane for selective recognition of Co2+ and Cu2+ ions and in silico antidiabetic activity

“…Silatranes are tricyclic organosilicon ethers that have various applications such as surface modification, chemosensing, coating, agriculture and various biological activities like antibacterial, antiprotozoal, antiviral, antiparasitic, and antioxidant properties. [20][21][22][23][24][25][26][27][28] Researchers are exploring ways to modify silatranes by combining them with other active molecules to enhance their applications. The acetylenic moiety, a frequently used component in organic chemistry, is being combined with the indole ring to enhance its biological and photophysical characteristics.…”

Design, Synthesis, Drug-Likeness and In Silico Prediction of Polycyclic Aromatic Schiff base Tethered Organosilatranes

“…Alternatively silatrane, with general formula N-[(CR 1 R 2 ) n O] 3 SiR, can be considered as hypervalent silicon species surrounded by three oxygen atoms and an exocyclic substrate. It includes three heterocyclic caged structures with triethanolamine and transannular bond between nitrogen and silicon atom [4].These pentacoordinated compounds acquires distorted trigonal bipyramidal geometry around silicon atom. The transannular dative bond between nitrogen and silicon is the feature of interest on account of its uniqueness of molecular structure, architectural beauty and peculiar stereoelectronic and chemical properties [5][6][7][8][9][10].…”