First-trimester maternal cell microRNA is a superior pregnancy marker to immunological testing for predicting adverse pregnancy outcome

Winger, Edward E.; Reed, Jane L.; Ji, Xuhuai

doi:10.1016/j.jri.2015.03.005

Cited by 38 publications

(50 citation statements)

References 27 publications

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“…The abundance and identity of miRNA that may be present in a single spermatocyte remains unknown [2]. miRNAs contribute to establishing immune tolerance at conception [45]. Altered immune-regulatory miRNAs during preconception and the first trimester are indicative of later pregnancy outcomes in humans ( n = 48) [45].…”

Section: New Kids On the Block: Mirnas Really Do Mattermentioning

confidence: 99%

“…miRNAs contribute to establishing immune tolerance at conception [45]. Altered immune-regulatory miRNAs during preconception and the first trimester are indicative of later pregnancy outcomes in humans ( n = 48) [45]. During placental development, miRNAs can bind to target genes responsible for cellular invasion, proliferation, apoptosis, and angiogenesis [44].…”

Section: New Kids On the Block: Mirnas Really Do Mattermentioning

confidence: 99%

“…Seven miRNAs in peripheral blood (miR-1, miR-133b, miR-199a-5p, miR-1267, miR-1229, miR-223, and miR-148a-3p) are related to the predisposition for pregnancy complications such as miscarriage and early- and late-onset pre-eclampsia [45]. They have a predictive value for adverse pregnancy outcomes and therefore have a role as potential biomarkers.…”

Section: Mirna-associated Pregnancy Complicationsmentioning

confidence: 99%

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Roles of MicroRNA across Prenatal and Postnatal Periods

Floris

Kraft

Altosaar

2016

IJMS

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Communication between mother and offspring in mammals starts at implantation via the maternal–placental–fetal axis, and continues postpartum via milk targeted to the intestinal mucosa. MicroRNAs (miRNAs), short, noncoding single-stranded RNAs, of about 22 nucleotides in length, are actively involved in many developmental and physiological processes. Here we highlight the role of miRNA in the dynamic signaling that guides infant development, starting from implantation of conceptus and persisting through the prenatal and postnatal periods. miRNAs in body fluids, particularly in amniotic fluid, umbilical cord blood, and breast milk may offer new opportunities to investigate physiological and/or pathological molecular mechanisms that portend to open novel research avenues for the identification of noninvasive biomarkers.

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Section: New Kids On the Block: Mirnas Really Do Mattermentioning

confidence: 99%

Section: New Kids On the Block: Mirnas Really Do Mattermentioning

confidence: 99%

Section: Mirna-associated Pregnancy Complicationsmentioning

confidence: 99%

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Roles of MicroRNA across Prenatal and Postnatal Periods

Floris

Kraft

Altosaar

2016

IJMS

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“…Pregnancy-associated diseases with placental origin represent multifactorial conditions in which both maternal and feto-placental factors are contributing, and the combination of these factors leads to differences in disease features. 14 PE is a hypertensive disorder of pregnancy (HDP) defined as new-onset hypertension (≥140 mmHg systolic or ≥90 mmHg diastolic blood pressure) arising after 20 gestational weeks (GW) and either proteinuria or thrombocytopenia, impaired liver or renal function, pulmonary or cerebral or visual signs. 15,16 Recently, it has been reported that proteinuria is not essential for the diagnosis of PE and does not correlate with outcomes.…”

Section: Introductionmentioning

confidence: 99%

Innate Immune System at the Maternal–Fetal Interface: Mechanisms of Disease and Targets of Therapy in Pregnancy Syndromes

Triggianese

Perricone

Chimenti

et al. 2016

American J Rep Immunol

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The maternal-fetal interface is an immunologically unique site that allows the tolerance to the allogenic fetus and maintains host defense against possible pathogens. Balanced immune responses are required for the maintenance of successful pregnancy. It has been demonstrated that innate immune disturbances may be responsible for some adverse pregnancy outcomes such as preeclampsia (PE); hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome; intrauterine growth restriction (IUGR); and recurrent spontaneous abortion (RSA). Observational studies suggest that immunomodulatory treatments in pregnancy-specific complications may improve both the hematological/biochemical features in the mother and the perinatal outcomes. The following review will discuss how recent and relevant findings in the field of the innate immunity have advanced our understanding of the role of inflammation and innate immune system in the pathogenesis of pregnancy failure and will discuss the therapeutic outcomes of the existing studies and clinical trials in light of these new insights.

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“…For example, increased circulating syncytiotrophoblast micro-particles is known as a predicting agent for preeclampsia and is associated with reduction of IFN-gamma in the 1 st trimester [24] which may leads to arterial remodeling failure. Another way to predict preeclampsia is assaying of the seven involved micro-RNAs proposed by Winger et al (refer to the full text of their article) [25]. For the other controversy which was about using of antiinflammatory and anti-coagulation treatments, the solution is writing meta-analysis for future paper and also genetic polymorphism screening of immunologic molecules in future original researches which was failed to consider even in high impact journals.…”

Section: Resultsmentioning

confidence: 99%