First trimester maternal exposures to endocrine disrupting chemicals and metals and fetal size in the Michigan Mother–Infant Pairs study

Goodrich, Jaclyn M.; Ingle, Mary E.; Domino, Steven E.; Treadwell, Marjorie C.; Dolinoy, Dana C.; Burant, Charles F.; Meeker, John D.; Padmanabhan, Vasantha

doi:10.1017/s204017441800106x

Cited by 59 publications

(25 citation statements)

References 56 publications

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“…Puttabyatappa et al. ( 2020 ) analyzed phthalates with lower GMs of first-trimester maternal urinary MCPP (

) and MBzP (

) compared with what we observed in our LIFECODES subsample for MCPP (

) and MBzP (

) ( Goodrich et al. 2019 ).…”

Section: Discussionsupporting

confidence: 60%

“…2020 ). Exposure levels of Pb in this sample [

] were comparable, but slightly lower than levels observed in the present LIFECODES subsample (

) ( Goodrich et al. 2019 ).…”

Section: Discussionsupporting

confidence: 42%

“…2019 ). The GM for first-trimester MCINP in that comparison study was

( Goodrich et al. 2019 ), although this metabolite was not measured in our LIFECODES subsample.…”

Section: Discussionmentioning

confidence: 88%

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Cross-Sectional Estimation of Endogenous Biomarker Associations with Prenatal Phenols, Phthalates, Metals, and Polycyclic Aromatic Hydrocarbons in Single-Pollutant and Mixtures Analysis Approaches

Aung

Ferguson

et al. 2021

Environ Health Perspect

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Background: Humans are exposed to mixtures of toxicants that can impact several biological pathways. We investigated the associations between multiple classes of toxicants and an extensive panel of biomarkers indicative of lipid metabolism, inflammation, oxidative stress, and angiogenesis. Methods: We conducted a cross-sectional study of 173 participants (median 26 wk gestation) from the LIFECODES birth cohort. We measured exposure analytes of multiple toxicant classes [metals, phthalates, phenols, and polycyclic aromatic hydrocarbons (PAHs)] in urine samples. We also measured endogenous biomarkers (eicosanoids, cytokines, angiogenic markers, and oxidative stress markers) in either plasma or urine. We estimated pair-wise associations between exposure analytes and endogenous biomarkers using multiple linear regression after adjusting for covariates. We used adaptive elastic net regression, hierarchical Bayesian kernel machine regression, and sparse-group LASSO regression to evaluate toxicant mixtures associated with individual endogenous biomarkers. Results: After false-discovery adjustment ( ), single-pollutant models yielded 19 endogenous biomarker signals associated with phthalates, 13 with phenols, 17 with PAHs, and 18 with trace metals. Notably, adaptive elastic net revealed that phthalate metabolites were selected for several positive signals with the cyclooxygenase ( ), cytochrome p450 ( ), and lipoxygenase ( ) pathways. Conversely, the toxicant classes that exhibited the greatest number of negative signals overall in adaptive elastic net were phenols ( ) and metals ( ). Discussion: This study characterizes cross-sectional endogenous biomarker signatures associated with individual and mixtures of prenatal toxicant exposures. These results can help inform the prioritization of specific pairs or clusters of endogenous biomarkers and exposure analytes for investigating health outcomes. https://doi.org/10.1289/EHP7396

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“…Puttabyatappa et al. ( 2020 ) analyzed phthalates with lower GMs of first-trimester maternal urinary MCPP (

) and MBzP (

) compared with what we observed in our LIFECODES subsample for MCPP (

) and MBzP (

) ( Goodrich et al. 2019 ).…”

Section: Discussionsupporting

confidence: 60%

“…2020 ). Exposure levels of Pb in this sample [

] were comparable, but slightly lower than levels observed in the present LIFECODES subsample (

) ( Goodrich et al. 2019 ).…”

Section: Discussionsupporting

confidence: 42%

See 1 more Smart Citation

Cross-Sectional Estimation of Endogenous Biomarker Associations with Prenatal Phenols, Phthalates, Metals, and Polycyclic Aromatic Hydrocarbons in Single-Pollutant and Mixtures Analysis Approaches

Aung

Ferguson

et al. 2021

Environ Health Perspect

Self Cite

View full text Add to dashboard Cite

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“…Samples were collected into polypropylene urine collection containers, aliquoted into glass vials, and frozen at −80°C until analysis. Total urinary BPA, BPF, and BPS were measured at NSF International (Ann Arbor, MI) using isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS), as reported previously [ 58 ]. Specific gravity was measured using a handheld digital refractometer (Atago Co., Ltd., Tokyo, Japan) at the time of sample analysis.…”

Section: Methodsmentioning

confidence: 99%

Maternal environmental exposure to bisphenols and epigenome-wide DNA methylation in infant cord blood

McCabe

Padmanabhan

Jones

et al. 2020

Environmental Epigenetics

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Maternal prenatal exposures, including bisphenol A (BPA), are associated with offspring’s risk of disease later in life. Alterations in DNA methylation may be a mechanism through which altered prenatal conditions (e.g. maternal exposure to environmental toxicants) elicit this disease risk. In the Michigan Mother and Infant Pairs Cohort, maternal first-trimester urinary BPA, bisphenol F, and bisphenol S concentrations were tested for association with DNA methylation patterns in infant umbilical cord blood leukocytes (N = 69). We used the Illumina Infinium MethylationEPIC BeadChip to quantitatively evaluate DNA methylation across the epigenome; 822 020 probes passed pre-processing and quality checks. Single-site DNA methylation and bisphenol models were adjusted for infant sex, estimated cell-type proportions (determined using cell-type estimation algorithm), and batch as covariates. Thirty-eight CpG sites [false discovery rate (FDR) <0.05] were significantly associated with maternal BPA exposure. Increasing BPA concentrations were associated with lower DNA methylation at 87% of significant sites. BPA exposure associated DNA methylation sites were enriched for 38 pathways significant at FDR <0.05. The pathway or gene-set with the greatest odds of enrichment for differential methylation (FDR <0.05) was type I interferon receptor binding. This study provides a novel understanding of fetal response to maternal bisphenol exposure through epigenetic change.

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“…Two of these reported no association between fetal exposure to BPA and gestational age at birth [7,8]. A few studies assessing the associations of bisphenol exposure with fetal ultrasound measurements showed inconsistent results [9][10][11][12]. To fully capture fetal growth variation, analyses on repeated measures of fetal growth are needed.…”

Section: Introductionmentioning

confidence: 99%

Maternal bisphenol urine concentrations, fetal growth and adverse birth outcomes: A population-based prospective cohort

et al. 2021

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Background Exposure to bisphenols may affect fetal growth and development. The trimester-specific effects of bisphenols on repeated measures of fetal growth remain unknown. Our objective was to assess the associations of maternal bisphenol urine concentrations with fetal growth measures and birth outcomes and identify potential critical exposure periods. Methods In a population-based prospective cohort study among 1379 pregnant women, we measured maternal bisphenol A, S and F urine concentrations in the first, second and third trimester. Fetal head circumference, length and weight were measured in the second and third trimester by ultrasound and at birth. Results An interquartile range increase in maternal pregnancy-averaged bisphenol S concentrations was associated with larger fetal head circumference (difference 0.18 (95% confidence interval (CI) 0.01 to 0.34) standard deviation scores (SDS), p-value< 0.05) across pregnancy. When focusing on specific critical exposure periods, any detection of first trimester bisphenol S was associated with larger second and third trimester fetal head circumference (difference 0.15 (95% CI 0.05 to 0.26) and 0.12 (95% CI 0.02 to 0.23) SDS, respectively) and fetal weight (difference 0.12 (95% CI 0.02 to 0.22) and 0.16 (95% CI 0.06 to 0.26) SDS, respectively). The other bisphenols were not consistently associated with fetal growth outcomes. Any detection of bisphenol S and bisphenol F in first trimester was also associated with a lower risk of being born small size for gestational age (Odds Ratio 0.56 (95% CI 0.38 to 0.74) and 0.55 (95% CI 0.36 to 0.85), respectively). Bisphenols were not associated with risk of preterm birth. Conclusions Higher maternal bisphenol S urine concentrations, especially in the first trimester, seem to be related with larger fetal head circumference, higher weight and a lower risk of being small size for gestational age at birth.

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First trimester maternal exposures to endocrine disrupting chemicals and metals and fetal size in the Michigan Mother–Infant Pairs study

Cited by 59 publications

References 56 publications

Cross-Sectional Estimation of Endogenous Biomarker Associations with Prenatal Phenols, Phthalates, Metals, and Polycyclic Aromatic Hydrocarbons in Single-Pollutant and Mixtures Analysis Approaches

Cross-Sectional Estimation of Endogenous Biomarker Associations with Prenatal Phenols, Phthalates, Metals, and Polycyclic Aromatic Hydrocarbons in Single-Pollutant and Mixtures Analysis Approaches

Maternal environmental exposure to bisphenols and epigenome-wide DNA methylation in infant cord blood

Maternal bisphenol urine concentrations, fetal growth and adverse birth outcomes: A population-based prospective cohort

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