First trimester maternal lipid levels and serum markers of small- and large-for-gestational age infants

Parlakgumus, Huriye Ayse; Aytaç, Pınar Çağlar; Kalaycı, Hakan; Tarım, Ebru

doi:10.3109/14767058.2013.799658

Cited by 20 publications

(24 citation statements)

References 29 publications

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“…Parity may also influence neonatal birth weight, and previous studies demonstrated that multiparous women were significantly associated with LGA infants [46,47]. However, another study reported no significant association between parity and SGA or LGA groups [48]. Our study suggests that there is no significant difference in parity among the 3 groups.…”

Section: Discussionsupporting

confidence: 41%

Cord Blood C-peptide, Insulin, HbA1c, and Lipids Levels in Small- and Large-for-Gestational-Age Newborns

et al. 2014

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BackgroundSmall- and large-for-gestational-age (SGA, LGA) newborns are associated with metabolic syndrome in their later life. Cord blood C-peptide, insulin, glycosylated hemoglobin (HbA1c), and lipids levels may be altered in SGA and LGA newborns; however, the results are conflicting. Therefore, this study aimed to determine the effect of cord blood markers on SGA and LGA newborns.Material/MethodsThis was a prospective cohort study and included 2873 term newborns of non-diabetic women. Among these newborns, 83 (2.9%) were SGA, 2236 (77.8%) were appropriate-for-gestational-age (AGA), and 554 (19.3%) were LGA newborns. Cord blood C-peptide, insulin, HbA1c, triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) levels were measured. The chi-square, Kruskal-Wallis, and Mann-Whitney tests were used to analyze categorical variables and continuous variables, respectively. Multinomial logistic regression analysis was used to determine the independent effect of these variables on SGA and LGA newborns.ResultsCord serum TG level was significantly higher in the SGA group than in AGA and LGA groups (p<0.05). The LGA group had significantly higher cord serum insulin level than AGA and SGA groups (p<0.05). After adjustment for confounding variables, including maternal age, parity, pre-pregnancy body mass index (BMI), education, annual household income, pregnancy-induced hypertension (PIH), mode of delivery, and newborn sex, high TG and insulin levels remained significantly associated with SGA and LGA newborns, respectively (p<0.05).ConclusionsHigh cord serum TG and insulin levels are independently associated with SGA and LGA newborns, respectively.

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Section: Discussionsupporting

confidence: 41%

Cord Blood C-peptide, Insulin, HbA1c, and Lipids Levels in Small- and Large-for-Gestational-Age Newborns

et al. 2014

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“…The risk of macrosomia was positively related to TG levels, while negatively related to HDL-C levels in non-diabetic pregnancies [9]. However other studies failed to nd any association [30,31]. In the present study, we found that the incidence of macrosomia was signi cantly increased in the hyperlipidemia group.…”

Section: Discussionsupporting

confidence: 42%

The Relationship Between Lipid Profile and Outcomes of Pregnant Women with Gestational Diabetes Mellitus and Hypertensive Disorders: A Retrospective Study

Chen

Wang

et al. 2020

Preprint

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Background Dyslipidemia during pregnancy in women with gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDP) has been extensively studied in western countries. However, similar researches have rarely been conducted in Asia. The present study aimed to evaluate maternal lipid profile changes in relation to pregnancy complications and clinical outcomes.Methods The medical records of 668 pregnant women were retrospectively analyzed. Maternal fasting serum lipids were assayed for total cholesterol (TC), triglycerides (TG), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), apolipoprotein A1 (Apo A1) and Apo B concentrations during the second trimesters. The atherogenic index of plasma (AIP) was calculated. The pregnancy complications included GDM and HDP. The clinical outcomes were collected by evaluating delivery mode, postpartum hemorrhage, macrosomia, birth weight, body length and neonatal Apgar score.Results Levels of TG and AIP were elevated while decreased TC and HDL-C was observed in women with GDM compared with that of the control group (p < 0.05). TG and AIP in HDP group were higher than in control group (p < 0.05). Significant differences were observed in postpartum hemorrhage, birth weight and body length between control group and women with GDM or HDP (p < 0.05). Compared with women with serum TG ≥ 2.5 mmol/L or TC ≥ 6.2 mmol/L, the incidence of GDM, cesarean section and macrosomia was lower in normal lipid group (p < 0.05). Spearman correlation analysis showed that the incidence of GDM was positively correlated with levels of TG (r = 0.226, p < 0.01) and AIP (r = 0.250, p < 0.01), while negative correlated with TC (r = -0.106, p < 0.01) and HDL-C (r = -0.190, p < 0.01). AIP was correlated positively with the incidence of HDP (r = 0.115, p = 0.043). According to the logistic regression analysis, each unit elevation in AIP increased the risk of GDM by 6.943 times (OR = 6.943, 95% CI: 1.761–27.374).Conclusions Lipid control, especially for women with GDM and HDP, might be a potential strategy for improving the pregnancy outcomes.

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“…Recently, some maternal lipid parameters have been identified as independent risk determinants of fetal overgrowth, especially in pregnancies complicated by GDM or with DM [ 15 , 18 ]. Several studies have demonstrated that in non-diabetic pregnancies, birth weight and the risk of macrosomia or large for gestational age (LGA) were positively associated with maternal serum triglyceride (TG) levels [ 16 , 19 , 20 ], and negatively associated with high-density lipoprotein cholesterol (HDL-C) levels [ 21 ], While other studies failed to find any association [ 22 , 23 ]. Studies have shown that patterns of maternal dyslipidemia and the prevalence of macrosomia vary across populations and ethnic groups [ 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

“…Several studies have demonstrated that in non-diabetic pregnancies, birth weight and the risk of macrosomia or large for gestational age (LGA) were positively associated with maternal serum triglyceride (TG) levels [ 16 , 19 , 20 ], and negatively associated with high-density lipoprotein cholesterol (HDL-C) levels [ 21 ], While other studies failed to find any association [ 22 , 23 ]. Studies have shown that patterns of maternal dyslipidemia and the prevalence of macrosomia vary across populations and ethnic groups [ 23 , 24 ]. While a few studies have explored the relationship between maternal serum lipids and neonatal birth weight in Chinese population, their sample sizes were relatively small [ 21 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Association of maternal serum lipids at late gestation with the risk of neonatal macrosomia in women without diabetes mellitus

et al. 2018

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BackgroundMacrosomia is a serious public health problem worldwide due to its increasing prevalence and adverse influences on maternal and neonatal outcomes. Maternal dyslipidemia exerts potential and adverse impacts on pregnant women and newborns. However, the association between maternal serum lipids and the risk of macrosomia has not yet been clearly elucidated. We explored the association between the maternal lipids profile at late gestation and the risk of having macrosomia among women without diabetes mellitus (DM).MethodsThe medical records of 5407 pregnant women giving birth to single live babies at term were retrospectively analyzed. Subjects with DM, hypertension, thyroid disorders and fetal malformation were excluded. Maternal fasting serum lipids were measured during late pregnancy. Logistic regression analysis was used to analyze the variables associated with the risk of macrosomia.ResultsMaternal serum triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) levels were related to macrosomia; each 1 mmol/L increase in TG resulted in a 27% increase in macrosomia risk, while each 1 mmol/L increase in HDL-C level resulted in a 37% decrease in macrosomia risk, even after adjusting for potential confounders. Notably, the risk of macrosomia increased progressively with increased maternal serum TG levels and decreased HDL-C levels. Compared with women with serum TG levels < 2.5 mmol/L, women with TG levels greater than 3.92 mmol/L had an approximately 2.8-fold increased risk of macrosomia. Compared with women with serum HDL-C levels above 2.23 mmol/L, women with HDL-C levels of less than 1.62 mmol/L had a 1.9-fold increased risk of giving birth to an infan with macrosomia. In addition, a higher risk of macrosomia was observed in women with simultaneous hypertriglyceridemia and low serum HDL-C levels (odds ratio [OR] 2.400, 95% confidence interval [CI]: 1.760–3.274) compared to those with hypertriglyceridemia or low serum HDL-C alone (OR 2.074, 95% CI: 1.609–2.673 and OR 1.363, 95% CI: 1.028–1.809, respectively).ConclusionsMaternal serum TG levels and HDL-C levels at late gestation are independent predictors of macrosomia in women without DM.Electronic supplementary materialThe online version of this article (10.1186/s12944-018-0707-7) contains supplementary material, which is available to authorized users.

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First trimester maternal lipid levels and serum markers of small- and large-for-gestational age infants

Abstract: PAPP-A was significantly associated with SGA after controlling for confounders.

Cited by 20 publications

References 29 publications

Cord Blood C-peptide, Insulin, HbA1c, and Lipids Levels in Small- and Large-for-Gestational-Age Newborns

Cord Blood C-peptide, Insulin, HbA1c, and Lipids Levels in Small- and Large-for-Gestational-Age Newborns

The Relationship Between Lipid Profile and Outcomes of Pregnant Women with Gestational Diabetes Mellitus and Hypertensive Disorders: A Retrospective Study

Association of maternal serum lipids at late gestation with the risk of neonatal macrosomia in women without diabetes mellitus

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