First trimester maternal serum PAPP‐A, β‐hCG and ADAM12 in prediction of small‐for‐gestational‐age fetuses

Pihl, Kasper; Larsen, Torben; Krebs, Lone; Christiansen, Michael

doi:10.1002/pd.2141

Cited by 57 publications

(48 citation statements)

References 41 publications

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“…The early identification of the fetuses at risk for SGA or LGA is of notable clinical interest; in fact, health resources could be used in a better way and prophylaxis could be done [15,20]. However, even if the association between the levels of PAPP-A and a low neonatal weight has been demonstrated, the sensitivity of such a screening method for the prediction of low birth weight and perinatal complications seems to be rather low (the positive correlation, when present, is moderate: the value of ρ is in the 0.3-0.7 range).…”

Section: Discussionmentioning

confidence: 99%

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Correlation of neonatal weight with maternal serum levels of pregnancy-associated plasma protein-A during the first trimester of pregnancy: a retrospective study

Giudice

Benintende

Nicolò

et al. 2014

Journal of Perinatal Medicine

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This study confirms the positive correlation between circulating concentrations of pregnancy-associated plasma protein-A and fetal growth. Low neonatal weight and factors that can cause this could be determined from the first trimester by measuring the concentrations of pregnancy-associated plasma protein-A in maternal serum. Even if the association between the levels of pregnancy-associated plasma protein-A and a low neonatal weight has been demonstrated, however, we have to say that the sensitivity of a such screening method for the prediction of low birth weight and perinatal complications seems to be rather low. The variations of pregnancy-associated plasma protein-A during the first trimester cannot be used as a marker of excessive fetal growth.

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Section: Discussionmentioning

confidence: 99%

“…Low levels of IGFs seem to be associated with implantation and placentation disturbances, which could be responsible for reduced fetal growth [3,15,21]. Studies on knockout mice have shown that the IGFs are crucial for correct embryonic development and fetal growth [2].…”

Section: Introduction Biochemical Assumptionmentioning

confidence: 98%

Correlation of neonatal weight with maternal serum levels of pregnancy-associated plasma protein-A during the first trimester of pregnancy: a retrospective study

Giudice

Benintende

Nicolò

et al. 2014

Journal of Perinatal Medicine

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“…ADAM12 has been studied as a first trimester marker for predicting pre-eclampsia [8]–[10], aneuploidy [8], [10]–[15] and small-for-gestational age fetuses [16], [17]. A clear biological explanation for the decreased level of ADAM12 in EPs does not exist; however, the predominant theory involving impaired placentation could account for ADAM12 playing an important role in the growth and function of the placenta [8].…”

Section: Discussionmentioning

confidence: 99%

Maternal Serum Disintegrin and Metalloprotease Protein-12 in Early Pregnancy as a Potential Marker of Adverse Pregnancy Outcomes

Yang

Guo

et al. 2014

PLoS ONE

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ObjectivesThe aim of this study was to determine whether the concentration of disintegrin and metalloprotease protein12 (ADAM12) in first trimester maternal serum can be used as a marker for first-trimester complete spontaneous abortions, missed abortions, ectopic pregnancies and hydatidiform moles.MethodsThe maternal serum concentrations of ADAM12 were measured in the range of 5–9+6 weeks of gestation using an automated AutoDelfia immunoassay platform in 9 cases of complete spontaneous abortion, 27 cases of missed abortions, 56 cases of ectopic pregnancies, 12 cases of hydatidiform moles, and 100 controls. Logistic regression analysis was used to determine significant factors for predicting adverse pregnancy outcomes in early pregnancy. Screening performance was assessed using receiver operating characteristic curves.ResultsTwo hundred and four women were enrolled in the study. In the control group, the level of ADAM12 increased with gestational age. The median ADAM12 levels in the spontaneous abortion (0.430 MoM), ectopic pregnancy (0.460 MoM) and hydatidiform mole (0.037 MoM) groups were lower than that in the control group, while the median ADAM12 level in the missed abortion group (1.062 MoM) was not significant from the controls (1.002 MoM). Logistic regression analysis demonstrated that the level of ADAM12 in maternal serum facilitated the detection of ectopic pregnancies (OR = 0.909; 95% CI = 0.841∼0.982) and complete spontaneous abortion (OR = 0.863; 95% CI = 0.787∼0.946).ConclusionsIn complete spontaneous abortion and ectopic pregnancy, ADAM12 maintained at low levels in early pregnancies, and there were significant differences compared to normal pregnancies. ADAM12 is a promising marker for the diagnosis of complete spontaneous abortion and ectopic pregnancy in symptomatic women, and under certain conditions, ADAM12 can diagnose ectopic pregnancy and spontaneous abortion before an ultrasonographic detection of the conditions.

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“…In addition, ADAM-12 levels have been shown to decrease in pregnancies which resulted in growth-restricted fetuses, supporting a role of ADAM-12 in fetal growth [30,31] . However, a recent study has found no significant difference in first-trimester maternal serum ADAM-12 concentrations between controls and pregnancies resulting in PE [32] .…”

Section: Adam-12 In Adverse Pregnancy Outcomesmentioning

confidence: 90%

Maternal Serum ADAM-12 as a Potential Marker for Different Adverse Pregnancy Outcomes

Matwejew

Cowans²,

Stamatopoulou³

et al. 2010

Fetal Diagn Ther

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Objective: To investigate first-trimester ADAM-12 levels in pregnancies which later develop hypertensive and growth complications. Methods: First-trimester serum samples (11⁺⁰ to 13⁺⁶ weeks) were retrieved from frozen storage. 47 samples with at least one of the following adverse outcomes: pre-eclampsia (PE), small for gestational age, HELLP syndrome and gestational hypertension were analysed and 452 controls matched to the cases by gestational age and length of storage were analysed. ADAM-12 levels were measured by the automated AutoDELFIA immunoassay platform. Results: ADAM-12 was found to increase with gestational age (11⁺⁰ to 13⁺⁶ weeks) and decrease with increasing maternal weight and in women who smoked. After correction, ADAM-12 median multiples of the median were increased in cases with HELLP syndrome, all PE and PE only. Conclusion: The increased first-trimester levels of ADAM-12 in PE and HELLP are in contrast with previous findings. The usefulness of ADAM-12 as a marker for adverse outcomes is still unclear.

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First trimester maternal serum PAPP‐A, β‐hCG and ADAM12 in prediction of small‐for‐gestational‐age fetuses

Abstract: Early prediction of fetuses being SGA is feasible with the combination of first trimester PAPP-A, beta-hCG and ADAM12. Screening performance is approaching clinical relevance. The inclusion of further markers is an attractive option.

Cited by 57 publications

References 41 publications

Correlation of neonatal weight with maternal serum levels of pregnancy-associated plasma protein-A during the first trimester of pregnancy: a retrospective study

Correlation of neonatal weight with maternal serum levels of pregnancy-associated plasma protein-A during the first trimester of pregnancy: a retrospective study

Maternal Serum Disintegrin and Metalloprotease Protein-12 in Early Pregnancy as a Potential Marker of Adverse Pregnancy Outcomes

Maternal Serum ADAM-12 as a Potential Marker for Different Adverse Pregnancy Outcomes

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