First-trimester screening for fetal growth restriction using Doppler color flow analysis of the uterine artery and serum PAPP-A levels in unselected pregnancies

He, B.; Hu, Chunhong; Zhou, Yuqing

doi:10.1080/14767058.2019.1701646

Cited by 12 publications

(19 citation statements)

References 24 publications

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“…The decreased mRNA levels of MEK1 and MAPK can induce FGR, suggesting that MEK1 and MAPK mRNA play a role in the pathogenesis of FGR. Abnormal expression levels of MEK1 and MAPK mRNA may also be one of the reasons for the induction of FGR [21][22][23][24].…”

Section: Discussionmentioning

confidence: 99%

Mechanism of MEK1-MAPK Pathway-based MiR520a-5p in Fetal Growth Restriction

Jha

2023

Preprint

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this research was developed to investigate the expression level of miR520a-5p in serum of fetal growth restriction (FGR) and the role of its target genes, mitogen-activated protein kinase (MAPK) and mitogen-activated protein kinase 1 (MEK1), in the pathogenesis of FGR. Thirty cases in the FGR group and 30 cases in the normal birth weight group (control group) were selected. MiR520a-5p expression and its target genes MEK1 and MAPK mRNA in the two groups were detected by RT‒PCR. The protein levels of the target genes MEK1 and MAPK of miR520a-5p were determined by Western blotting. The Spearman grade correlation was used to analyze the correlation between the expression levels of miR520a-5p and MEK1 in serum of FGR group and the correlation between MEK1 and MAPK expression. Compared with the control group, the expression of miR520a-5p in the FGR group was significantly increased (P < 0.05). MEK1 and MAPK mRNA levels of miR520a-5p target genes in the FGR group were drastically reduced (P < 0.05), while their protein levels were decreased (P < 0.05). Spearman rank correlation analysis suggested a negative correlation between miR-520a-5p and MEK1 (r = − 0.667; P < 0.05) and a positive correlation between MEK1 and MAPK (r = 0.46; P < 0.05). MEK1 and MAPK mRNA expressions in fetal growth and development were detected, and the decreased expression of MEK1 and MAPK mRNA was correlated with the pathogenesis of FGR. MiR520a-5p may participate in the pathogenesis of FGR through the MIRR520A-5P-MEK1-MAPK signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Mechanism of MEK1-MAPK Pathway-based MiR520a-5p in Fetal Growth Restriction

Jha

2023

Preprint

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“…In recent years, many studies have been conducted about IUGR, which is an important cause of perinatal mortality and morbidity, to determine if it can be predicted early in both the first and second trimesters [16,17]. Sotiriadis et al stated that 60 % of the fetuses with late IUGR development can be detected with the addition of uterine artery (Uta) PI Doppler measurement examined in both the first and second trimesters along with the first-trimester combined serum markers and maternal factors [16]. Yu N et al combined the first-trimester serum PAPP-A and ADAM12 markers with the second trimester Uta PI measurement values and reported the detection rate of the fetuses with IUGR development as 68 % [18].…”

Section: Discussionmentioning

confidence: 99%

Is ProBNP a New Marker for Predicting Intrauterine Growth Restriction?

Eroğlu¹,

Tonyalı²,

Örgül³

et al. 2021

Z Geburtshilfe Neonatol

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Purpose To evaluate the usability of first-trimester maternal serum ProBNP levels in the prediction of intrauterine growth restriction (IUGR). Methods In this prospective study, blood samples taken from 500 women who applied to our polyclinic for routine serum aneuploidy screening between the 11–14th gestational weeks were centrifuged. The obtained plasma samples were placed in Eppendorf tubes and stored at −80+°C. For the final analysis, first-trimester maternal serum ProBNP levels of 32 women diagnosed with postpartum IUGR and 32 healthy women randomly selected as the control group were compared. FGR was defined as estimated fetal weight below the 10th percentile for the gestational age. Results The mean ProBNP levels were statistically and significantly higher in the women with intrauterine growth restriction (113.73±94.69 vs. 58.33±47.70 pg/mL, p<0.01). At a cut-off level of 50.93, ProBNP accurately predicted occurrence of IUGR (AUC+= 0.794 (95% confidence interval 0.679–0.910), p+= 0.001) with sensitivity and specificity rates of 78.1 and 69.0%, respectively. Conclusion First-trimester serum ProBNP level was significantly higher in women who developed IUGR compared to healthy controls. First-trimester ProBNP level can be used as a potential marker to predict the development of IUGR in pregnant women.

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“…1 A). Así mismo, la combinación de los estudios de flujo Doppler de la AUt con marcadores bioquímicos, como el factor de crecimiento placentario o la proteína A en plasma asociada al embarazo, puede mejorar la predicción temprana de RCF 24,25 .…”

Section: Arterias Uterinasunclassified

Utilidad de la ecografía Doppler en el diagnóstico, el pronóstico y el manejo de la restricción del crecimiento fetal: situación en Chile

Sandoval¹,

Véliz²,

Sepúlveda³

et al. 2022

RECHOG

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Introducción: La restricción del crecimiento fetal (RCF) se define como la disminución patológica de la tasa de crecimiento fetal, generalmente asociada a insuficiencia placentaria. Se diagnostica mediante ultrasonografía obstétrica y velocimetría Doppler, pero no existe un consenso global respecto a los parámetros referenciados. Objetivo: Brindar una revisión actualizada de la aproximación clínica de la RCF en Chile, enfocada en el uso de la ultrasonografía Doppler como herramienta fundamental para el diagnóstico, el pronóstico y el manejo de esta patología, y realizar una comparativa con respecto a otros países. Método: Se realizó una revisión con palabras clave en las bases de datos PubMed y SciELO. Resultados: Se obtuvieron 89 referencias bibliográficas, logrando una revisión de datos actualizados del uso del Doppler en la RCF tanto en el mundo como en Chile. Conclusiones: La Guía Perinatal 2015 publicada en Chile carece de actualización con los conocimientos y la evidencia científica más recientes. Sin embargo, concuerda en gran parte con los lineamientos y las pautas generales de manejo de la RCF de las diferentes guías clínicas analizadas. Las discrepancias entre las guías revisadas podrían explicarse por la gran variabilidad de la evidencia de los estudios científico-clínicos, los cuales es importante unificar a través de una guía que promueva una estandarización de la atención de la RCF en el país.

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First-trimester screening for fetal growth restriction using Doppler color flow analysis of the uterine artery and serum PAPP-A levels in unselected pregnancies

Cited by 12 publications

References 24 publications

Mechanism of MEK1-MAPK Pathway-based MiR520a-5p in Fetal Growth Restriction

Mechanism of MEK1-MAPK Pathway-based MiR520a-5p in Fetal Growth Restriction

Is ProBNP a New Marker for Predicting Intrauterine Growth Restriction?

Utilidad de la ecografía Doppler en el diagnóstico, el pronóstico y el manejo de la restricción del crecimiento fetal: situación en Chile

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