The main directions of the destructive economic impact on business activities in the national security system have been identified, which allowed to identify possible risks for business activities and to develop a set of preventive measures to reduce the negative impact of external factors. Given the current conditions of the macroeconomic situation, it is necessary to constantly monitor the processes that take place in the external environment and have an impact on the state of economic security of business. With the help of international rating indices, which are an important tool, a significant reference point and an external source of information, Ukraine's place in international rankings has been tracked in the second section and a comprehensive assessment has been made, as the relevant rankings places by which world organizations mark Ukraine are indicators of its development. The interrelation and influence of the given indicators on the economic security of entrepreneurial activity are substantiated. According to the study of Ukraine's position in international rankings, it is concluded that Ukraine's position is currently unsatisfactory, Ukraine has not yet created safe conditions for business development: unstable tax legislation, significant corruption pressure and currency restrictions, lack of serious gains in investment attractiveness and to ensure national competitiveness, state support for business development is insufficient and unfocused; limited opportunities for financing state programs for business development. Entrepreneurial activity management in Ukraine is a direction of state policy, a set of measures and forms of economic, legal, and organizational impact on business and entrepreneurs, including through state support and protection of business entities, as well as state control over compliance requirements of the legislation by subjects of such an activity.