Fisetin averts oxidative stress in pancreatic tissues of streptozotocin-induced diabetic rats

Abstract

Persistent hyperglycemia is associated with chronic oxidative stress which contributes to the development and progression of diabetes-associated complications. The sensitivity of pancreatic β-cells to oxidative stress has been attributed to their low content of antioxidants compared with other tissues. Bioactive compounds with potent antidiabetic properties have been shown to ameliorate hyperglycemia mediated oxidative stress. Recently, we have reported that oral administration of fisetin (10 mg/Kg b.w.), a bioflavonoid found to be present in strawberries, persimmon, to STZ-induced experimental diabetic rats significantly improved normoglycemia. The present study was aimed to evaluate the antioxidant potential of fisetin in both in vitro and in vivo. Diabetes was induced by single intraperitoneal injection of streptozotocin (50 mg/kg body weight). Fisetin was administered orally for 30 days. At the end of the study, all animals were killed. Blood samples were collected for the biochemical estimations. The antioxidant status was evaluated. Histological examinations were performed on pancreatic tissues. Fisetin treatment showed a significant decline in the levels of blood glucose, glycosylated hemoglobin (HbA1c), NF-kB p65 unit (in pancreas) and IL-1β (plasma), serum nitric oxide (NO) with an elevation in plasma insulin. The treatment also improved the antioxidant status in pancreas as well as plasma of diabetic rats indicating the antioxidant potential of fisetin. In addition, the results of DPPH and ABTS assays substantiate the free radical scavenging activity of fisetin. Histological studies of the pancreas also evidenced the tissue protective nature of fisetin. It is concluded that, fisetin possesses antioxidant and anti-inflammatory property and may be considered as an adjunct for the treatment of diabetes.

The plant flavonoid, fisetin alleviates cigarette smoke‐induced oxidative stress, and inflammation in Wistar rat lungs

“…In addition, the CS-induced inflammatory cell population in BALF was markedly reduced in fisetin-treated rats supporting the preventive effects of fisetin against CS-induced lung tissue damage. Supporting our findings, fisetin has been shown to rescue different organs from inflammation-induced tissue damage (Feng, Jiang, Sun, Fu, & Li, 2016;Prasath, Sundaram, & Subramanian, 2013;Sahu et al, 2014).…”

Antihyperlipidemic Effect of Fisetin, a Bioflavonoid of Strawberries, Studied in Streptozotocin‐Induced Diabetic Rats

“…Fisetin supplementation has been reported to exhibit hypocholesterolemic effects by modulating the expression of genes associated with cholesterol and bile acid metabolism . Recently, we have evaluated the antidiabetic, antioxidant, and tissue protective nature of fisetin in streptozotocin (STZ)‐induced experimental diabetic rats . In the present study, an attempt is made to explore the antihyperlipidemic role of fisetin in STZ‐induced experimental diabetic rats.…”

Isolation of Fisetin from Elaeagnus indica Serv. Bull. (Elaeagnaceae) with antioxidant and antiproliferative activity

“…Recently, several researchers worked on the antioxidant potential of fisetin by performing various tests. [18][19][20] Wherein Phenolic hydroxyl groups are prone to donate a hydrogen atom to free radicals and extend conjugated aromatic system to delocalize an unpaired electron. 21 DPPH radical scavenging activity guided isolation of acetone extract of E. indica yielded a flavonol compound, i.e.…”