Fish and omega-3 fatty acid intake in relation to circulating fibroblast growth factor 23 levels in renal transplant recipients

Baia, Leandro C.; Berg, Else van den; Vervloet, Marc G.; Heilberg, Ita Pfeferman; Navis, Gerjan; Bakker, Stephan J. L.; Geleijnse, Johanna M.; Kromhout, Daan; Soedamah‐Muthu, Sabita S.; Borst, Martin H. de

doi:10.1016/j.numecd.2014.06.006

Cited by 17 publications

(16 citation statements)

References 29 publications

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“…First, given the cross-sectional nature of the data, we cannot establish whether it is omega-3 affecting microbiome diversity or the other way round. On the other hand, it is well known that omega-3 circulating levels are reflective of dietary intake 66 and although the associations we find with estimates of omega-3 dietary intake are weaker than with serum levels, this is likely to simply reflect the error of accurate estimates of intake from food questionnaire data compared to the accuracy of serum level measurements. Therefore, we hypothesize that it is intake of PUFAs and in particular of DHA that results in higher microbiome diversity and increased Lachnospiraceaes abundance.…”

Section: Discussioncontrasting

confidence: 66%

Omega-3 fatty acids correlate with gut microbiome diversity and production of N-carbamylglutamate in middle aged and elderly women

Menni

Zierer

Pallister

et al. 2017

Sci Rep

201

113

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Omega-3 fatty acids may influence human physiological parameters in part by affecting the gut microbiome. The aim of this study was to investigate the links between omega-3 fatty acids, gut microbiome diversity and composition and faecal metabolomic profiles in middle aged and elderly women. We analysed data from 876 twins with 16S microbiome data and DHA, total omega-3, and other circulating fatty acids. Estimated food intake of omega-3 fatty acids were obtained from food frequency questionnaires. Both total omega-3and DHA serum levels were significantly correlated with microbiome alpha diversity (Shannon index) after adjusting for confounders (DHA Beta(SE) = 0.13(0.04), P = 0.0006 total omega-3: 0.13(0.04), P = 0.001). These associations remained significant after adjusting for dietary fibre intake. We found even stronger associations between DHA and 38 operational taxonomic units (OTUs), the strongest ones being with OTUs from the Lachnospiraceae family (Beta(SE) = 0.13(0.03), P = 8 × 10−7). Some of the associations with gut bacterial OTUs appear to be mediated by the abundance of the faecal metabolite N-carbamylglutamate. Our data indicate a link between omega-3 circulating levels/intake and microbiome composition independent of dietary fibre intake, particularly with bacteria of the Lachnospiraceae family. These data suggest the potential use of omega-3 supplementation to improve the microbiome composition.

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Section: Discussioncontrasting

confidence: 66%

Omega-3 fatty acids correlate with gut microbiome diversity and production of N-carbamylglutamate in middle aged and elderly women

Menni

Zierer

Pallister

et al. 2017

Sci Rep

201

113

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“…Serum calcium was corrected for hypoalbuminemia (<40 g/L) using the following formula: corrected calcium = serum calcium (mmol/L) + 0.02 × [40 − serum albumin (g/L)]. Intact FGF-23 was measured using a commercially available ELISA kit (Kainos Laboratories, Inc., Tokyo, Japan) (Baia et al 2014 ). Information on participants’ health status, medical history and medication use was extracted from patient records.…”

Section: Methodsmentioning

confidence: 99%

Plasma ADMA associates with all-cause mortality in renal transplant recipients

et al. 2015

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Asymmetric dimethylarginine (ADMA) is a key endogenous inhibitor of endothelial NO synthase that affects endothelial function, blood pressure and vascular remodeling. Increased plasma levels of ADMA are associated with worse outcome from cardiovascular disease. Due to endothelial dysfunction before and after kidney transplantation, renal transplant recipients (RTR) are at high risk for the alleged deleterious effects of ADMA. We investigated the associations of ADMA levels with all-cause mortality and graft failure in RTR. Plasma ADMA levels were determined in 686 stable outpatient RTR (57 % male, 53 ± 13 years), with a functioning graft for ≥1 year. Determinants of ADMA were evaluated with multivariate linear regression models. Associations between ADMA and mortality were assessed using multivariable Cox regression analyses. The strongest associations with plasma ADMA in the multivariable analyses were male gender, donor age, parathyroid hormone, NT-pro-BNP and use of calcium supplements. During a median follow-up of 3.1 [2.7–3.9] years, 79 (12 %) patients died and 45 (7 %) patients developed graft failure. ADMA was associated with increased all-cause mortality [HR 1.52 (95 % CI 1.26–1.83] per SD increase, P < 0.001], whereby associations remained upon adjustment for confounders. ADMA was associated with graft failure [HR 1.41 (1.08–1.83) per SD increase, P = 0.01]; however, upon addition of eGFR significance was lost. High levels of plasma ADMA are associated with increased mortality in RTR. Our findings connect disturbed NO metabolism with patient survival after kidney transplantation.

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“…34 Donadio where consumption of fish and seafoods is also relatively high. 7,12,38,39 The cumulative incidence of adverse events during follow-up did not differ between the groups. Also, explorative studies investigating effects of marine n-3 FA consumption on mechanisms involved in development of renal graft fibrosis would be of interest.…”

mentioning

confidence: 87%

“…Also, explorative studies investigating effects of marine n-3 FA consumption on mechanisms involved in development of renal graft fibrosis would be of interest. 7,12,38,39 The cumulative incidence of adverse events during follow-up did not differ between the groups. Gastrointestinal discomfort was experienced by nearly a third of the patients and is common in renal transplant recipients receiving mycophenolate and tacrolimus.…”

mentioning

confidence: 87%

Effects of marine n-3 fatty acid supplementation in renal transplantation: A randomized controlled trial

Eide

Reinholt

Jenssen

et al. 2019

American Journal of Transplantation

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Marine n-3 fatty acids (FAs) may exert beneficial effects on inflammation, fibrosis, and endothelial function, which could preserve renal graft function. In this randomized controlled trial, 132 Norwegian renal transplant recipients received either 2.6 g of marine n-3 FAs or olive oil (control) daily for 44 weeks, in addition to standard care. Thirty patients did not complete the trial. The primary endpoint was change (Δ) in measured glomerular filtration rate (mGFR) during follow-up. We found no significant difference in Δ mGFR between the marine n-3 FA group and controls (6.7 vs 3.8 mL/min per 1.73 m , P = .15). Significant beneficial effects from marine n-3 FA supplementation were, however, seen in secondary endpoints plasma triglycerides, plasma high-sensitivity C-reactive protein, and brachial artery flow-mediated dilation. In the per-protocol population, the renal graft indices percent interstitial fibrosis and Chronic Allograft Damage Index also were significantly lower in the marine n-3 FA group. The cumulative incidence of adverse events did not differ between the marine n-3 FA group (n = 218) and controls (n = 240). In conclusion, marine FA supplementation did not improve renal function compared with controls, but was safe, lowered plasma triglyceride and high-sensitivity C-reactive protein levels, and improved endothelial function (Clinical.Trials.gov identifier NCT01744067).

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Fish and omega-3 fatty acid intake in relation to circulating fibroblast growth factor 23 levels in renal transplant recipients

Abstract: A higher intake of fish and dietary n-3 fatty acids (EPA-DHA) is related to lower circulating FGF23 levels in renal transplant recipients. Further research is needed to assess the causality of this association and the clinical implications.

Cited by 17 publications

References 29 publications

Omega-3 fatty acids correlate with gut microbiome diversity and production of N-carbamylglutamate in middle aged and elderly women

Omega-3 fatty acids correlate with gut microbiome diversity and production of N-carbamylglutamate in middle aged and elderly women

Plasma ADMA associates with all-cause mortality in renal transplant recipients

Effects of marine n-3 fatty acid supplementation in renal transplantation: A randomized controlled trial

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