Fish consumption and mortality from coronary heart disease.

Norell, Staffan E.; Ahlbom, Anders; Feychting, Maria; Pedersen, Nanna

doi:10.1136/bmj.293.6544.426

Cited by 196 publications

(65 citation statements)

References 2 publications

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“…Epidemiological studies on Greenland Eskimos have shown a correlation between low incidence of coronary heart disease (CHD) and high consumption of fish products (1). Subsequent studies have also confirmed these findings (2,3). It is well established that free radical damage contributes to the etiology of cardiovascular disease as well as other diseases such as diabetes mellitus, cataract etc.…”

Section: Introductionsupporting

confidence: 59%

Oxidant status and lipid profile in vegetarians and fish eaters

Cariappa

Poornima

Nandini

et al. 2005

Indian J Clin Biochem

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Habitual consumption of moderate amounts of fish is associated with reduced mortality from coronary heart disease. However the beneficial effects offish enriched diet seem contradictory, due to the susceptibility of the PUFAs in them to oxidation. It is also acclaimed that vegetarians in general, have a lower serum total cholesterol and LDL-cholesterol and a better antioxidant status. This contradiction was the basis for the study, where the validity of the above finding was tested in a general population consuming a vegetarian or predominantly fish diet as a regular dietary habit. The oxidant status and the lipid profile of 23 vegetarians and 22 fish eaters was studied by estimating the plasma lipid peroxides measured as malondialdehyde (MDA) and the lipid parameters viz. Total Cholesterol (TC), HDL-Cholesterol (HDL-C) and tdglyceddes (TG). Statistical analysis was carded out to compare the MDA values and the lipemic status between the two groups. MDA was also correlated with the various lipid indices among the study groups. None of the compared and correlated values was statistically significant, although certain altered trends were seen. From this study, it may be concluded that oxidant status and lipid profile does not vary significantly in the two groups, suggesting that neither a vegetarian diet nor a fish diet has a definite benefit over the other.

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Section: Introductionsupporting

confidence: 59%

Oxidant status and lipid profile in vegetarians and fish eaters

Cariappa

Poornima

Nandini

et al. 2005

Indian J Clin Biochem

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“…This association was independent of other coronary heart disease risk factors. This inverse association was confirmed by the results of three other cohort studies: two from the USA, the Western Electric and the MRFIT study and by the Swedish Twin Study (Shekelle et al 1985;Norell et al 1986;Dolecek & Grandits, 1991). Also in a case-control study carried out among Italian women an inverse relationship was found between fish consumption and myocardial infarction (Gramenzi et al 1990).…”

supporting

confidence: 62%

Epidemiological aspects of fish in the diet

Kromhout

1993

Proc. Nutr. Soc.

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“…Several epidemiological studies have revealed an inverse relationship between ®sh oil consumption and the incidence or mortality of coronary heart disease (CHD) (Norell et al, 1986;Gibson, 1988;Berg-Schmidt et al, 1993). The bene®cial effects of ®sh oil are related to their content of long chain n-3 polyunsaturated fatty acids (n-3 PUFA) (Nordoy et al, 1994).…”

Section: Introductionmentioning

confidence: 99%

Effects of fish oil supplementation on apolipoprotein B100 production and lipoprotein metabolism in normolipidaemic males

et al. 1998

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Objective: To evaluate the effects of four weeks of ®sh oil supplementation on apolipoprotein B100 production and lipoprotein metabolism in normolipidaemic males. Design and subjects: Very low density lipoprotein (VLDL) apolipoprotein B100 (apoB100) kinetics in ten healthy, white males, aged 22±43 y (mean 32 y) were investigated using a 13 C-leucine technique and gas chromatography-mass spectrometry before and after ®sh oil supplementation. Intervention: All subjects received 10 g (1.8 g EPA, 1.2 g DHA)ad of ®sh oil concentrate for four weeks. Results: Fish oil supplementation resulted in a decrease of total plasma VLDL (mean AE s.d. 1.11 AE 0.41 vs 0.87 AE 0.28 mmolal, P`0.05) and triacylglycerol concentrations (0.74 AE 0.27 vs 0.48 AE 0.21 mmolal, P`0.01). VLDL apoB100 pool size was decreased without alteration of the fractional synthetic rate but a signi®cant decrease of apoB100 production (2.23 AE 0.90 vs 1.54 AE 0.52 mgadlah, P`0.02). Following ®sh oil supplementation plasma concentrations of glucose and insulin as well as lipoprotein and hepatic lipase activities were unchanged. Fasting plasma concentrations of non-esteri®ed fatty acid (NEFA) were decreased (0.45 AE 0.12 vs 0.33 AE 0.10 mmolal, P`0.05). Conclusions: Dietary supplementation with ®sh oil in healthy males results in decreased VLDL-triacylglycerol concentrations through a decrease in VLDL particle synthesis. The decrease in NEFA substrate supply also contributes. Sponsorship: Fish oil (Maxepa 1 ) was supplied by Seven Seas Ltd, Hull, England, free of charge. Dr OAF Bodamer was funded by the`Deutsche Forschungsgemeinschaft' (Bo 1193a1-2).

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Fish consumption and mortality from coronary heart disease.

Cited by 196 publications

References 2 publications

Oxidant status and lipid profile in vegetarians and fish eaters

Oxidant status and lipid profile in vegetarians and fish eaters

Epidemiological aspects of fish in the diet

Effects of fish oil supplementation on apolipoprotein B100 production and lipoprotein metabolism in normolipidaemic males

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