Fish liver oil and propolis as protective natural products against the effect of the anti-epileptic drug valproate on immunological markers of bone formation in rats

Elwakkad, Amany; El-Shamy, Karima Abbas; Sibaii, Hiba

doi:10.1016/j.eplepsyres.2008.03.008

Cited by 15 publications

(9 citation statements)

References 52 publications

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“…The higher serum RANKL observed in our study following SVP is in agreement with preclinical study demonstrating increased RANKL levels in rats treated with valproate (13). RANKL activates and/or induces various transcription factors including nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), c-Fos and nuclear factor of activated Tcells c1 (NFATc1), which act as positive modulators of osteoclast differentiation (14).…”

Section: Discussionsupporting

confidence: 91%

Carbamazepine, Sodium Valproate and Levetiracetam Modulate Wnt Inhibitors in Indian Women with Epilepsy

Parveen

Tripathi

Vohora

2020

ANAMS

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Background: Antiepileptic drug (AED) therapy has been claimed to deteriorate bone health. Majority of the research was inclined towards vitamin-D deficiency as the patho-mechanism. However, after the role of Wnt in bone metabolism was discovered, it has paved way for investigating the role of Wnt inhibitors in mediating effects on bone accrual. Recently, we have reported the modulation of two Wnt inhibitors, sclerostin and dickkopf-1 (DKK-1), following AED therapy in Indian women with epilepsy, however, the subgroup analysis for individual drug is elucidated in this report. Methods: Individual analysis for our earlier cross-sectional study on three AEDs, carbamazepine (CBZ), sodium valproate (SVP) and levetiracetam (LTM), on sclerostin and dickkopf-1, and their correlation with receptor activator of nuclear factor kappaB ligand (RANKL) and serum 25-hydroxy vitamin D (25OHD) was assessed in Indian women with epilepsy. Results: We observed enhanced sclerostin and 25OHD levels with all three AEDs while serum RANKL was higher with SVP and LTM only. Further, serum DKK-1 levels were lowered with CBZ and LTM. Sclerostin showed a positive correlation with RANKL in CBZ group, while DKK-1 presented no such relationship. Conclusion: As sclerostin is more specific than DKK-1, we may conclude that these drugs may compromise bone health through disturbance in Wnt signaling mechanisms.

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Section: Discussionsupporting

confidence: 91%

Carbamazepine, Sodium Valproate and Levetiracetam Modulate Wnt Inhibitors in Indian Women with Epilepsy

Parveen

Tripathi

Vohora

2020

ANAMS

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“…Recently, Elwakkad et al. postulated that VPA activate osteoclast indirectly through activating the production of receptor activator nuclear factor‐kappa B ligand (RANKL) in osteoblasts and inhibition of osteoprotegerin through stimulating the secretion of PTH and up‐regulation of IL‐18 [24]. In fact, VPA can regulate the expression of interleukin‐18 a cytokine with antitumor and proinflamatory properties, by increasing the expression of IL‐18 (IL‐18) protein and up‐regulate the mRNA and activate IL‐18 full length promotor [25].…”

Section: Discussionmentioning

confidence: 99%

“…Although our study was not designed to determine the mechanism of VPA-induced bone alteration, our findings suggest that enhanced values of bone turnover markers shown in post-pubertal males were induced by a direct effect of VPA on bone cells, which might increase both osteoclast and osteoblast activity. Recently, Elwakkad et al postulated that VPA activate osteoclast indirectly through activating the production of receptor activator nuclear factor-kappa B ligand (RANKL) in osteoblasts and inhibition of osteoprotegerin through stimulating the secretion of PTH and up-regulation of IL-18 [24]. In fact, VPA can regulate the expression of interleukin-18 a cytokine with antitumor and proinflamatory properties, by increasing the expression of IL-18 (IL-18) protein and up-regulate the mRNA and activate IL-18 full length promotor [25].…”

Section: Discussionmentioning

confidence: 99%

A 12‐month longitudinal study of calcium metabolism and bone turnover during valproate monotherapy

Verrotti

Agostinelli

Coppola³

et al. 2010

Euro J of Neurology

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“…(iii) Group III (Omega-3 fatty acid group) (10 rats): Each rat will be gavaged orally (300 mg/kg body weight omega-3 fatty acid dissolved in 1 ml of distilled water once daily (Davood et al, 2017). (iv) Group IV (Sodium Valproate group) (10 rats): Each rat will be gavaged orally with 400 mg/kg body weight of sodium valproate dissolved in 1ml of distilled water once daily (Elwakkad et al, 2008). (v) Group V (Sodium Valproate and L-arginine group) (10 rats): Each rat will be gavaged orally with (300mg/kg body weight Larginine) 15 min before (400 mg/kg body weight sodium valproate) once daily.…”

Section: Methodsmentioning

confidence: 99%

The amelorative effect of L-arginin and omega-3 fatty acid against sodium valproate induced hepatotoxicity

Dalia¹,

Marwa²,

Walaa³

et al. 2018

J. Toxicol. Environ. Health Sci.

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Sodium valproate (VPA) used in epilepsy and has hepatotoxic effect in mammals. This work is to assess the role of L-arginin and omega-3 fatty acid against VPA oxidative stress on liver. This study was carried out on 70 rats divided into 7 groups each of 10 rats treated orally once daily 6days/ week; Group I (control), Group II (L-arginin): each rat was received 300 mg/kg L-arginin, Group III (omega-3): each rat received 300 mg/kg omega-3, Group IV (VIA): Each rat received 400 mg/kg VPA. Group V (VPA and L-arginin): Each rat received the previous doses. Group VI (VPA and omega-3): as before. Group VII (VPA, L-arginin and omega-3 group): as before. There was a significant increase in the mean values of AST, ALT, ALP and TBL in VPA treated group. Upon supplementation with L-arginin or omega-3 to VPA treated rats there was a significant decrease in the mean values of AST, ALT, ALP and TBL. Microscopic examination of liver section of VPA treated rat revealed vacuolated hepatocytes, focal necrosis, and enlarged portal tract. VPA toxicity induced severe liver damage in rats, and administration of either L-arginin or omega-3 protecting liver tissues.

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Fish liver oil and propolis as protective natural products against the effect of the anti-epileptic drug valproate on immunological markers of bone formation in rats

Cited by 15 publications

References 52 publications

Carbamazepine, Sodium Valproate and Levetiracetam Modulate Wnt Inhibitors in Indian Women with Epilepsy

Carbamazepine, Sodium Valproate and Levetiracetam Modulate Wnt Inhibitors in Indian Women with Epilepsy

A 12‐month longitudinal study of calcium metabolism and bone turnover during valproate monotherapy

The amelorative effect of L-arginin and omega-3 fatty acid against sodium valproate induced hepatotoxicity

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