Fish oil feeding enhances lymphocyte proliferation but impairs virus-specific T lymphocyte cytotoxicity in mice following challenge with influenza virus

Byleveld, M; Pang, Gerald; Clancy, Robert; Roberts, David

doi:10.1046/j.1365-2249.2000.01135.x

Cited by 27 publications

(14 citation statements)

References 28 publications

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“…In fact, the study of this intracellular pathogen has increased our knowledge of the diverse interactions between this biological mediator and the innate and adaptive immune responses. Moreover, other investigations have also demonstrated the reduction of host immune resistance to different bacteria or viruses in animals fed polyunsaturated fatty acids (3,4,8,28,29).…”

Section: Discussionmentioning

confidence: 98%

Relevance of Dietary Lipids as Modulators of Immune Functions in Cells Infected with Listeria monocytogenes

Puertollano

Pablo

Cienfuegos

2002

Clin Vaccine Immunol

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Nutritional status may have significant importance for the immune system, and particularly, unsaturated fatty acids may serve as modulators of immune functions. Clinical and epidemiological studies have demonstrated that fatty acids are involved in the reduction of the inflammatory processes that occur in diseases characterized by an overactivation of the immune system. At the same time, an increase in susceptibility to infection has also been reported. The importance of immune system modulation by dietary lipids in the presence of an intracellular bacterial pathogen, such as Listeria monocytogenes, was evaluated in the present study. BALB/c mice were divided into four groups which were each fed a low-fat (2.5% by weight) diet, an olive oil (OO; 20% by weight) diet, a fish oil (FO; 20% by weight) diet, or a hydrogenated coconut oil (HCO; 20% by weight) diet for 4 weeks. In each group, lymphocye proliferation was measured, and a reduction in the stimulation index was observed in the FO and HCO groups. Cytotoxicity exerted by L. monocytogenes was increased in the groups fed diets containing OO and FO after 6 h of incubation with the bacterium. An important increase in the production of reactive oxygen species was found in the groups fed the HCO diet after 12 h of incubation with L. monocytogenes. Finally, invasion and adhesion factors were not modified substantially by the action of dietary lipids, although these factors were reduced in cells from mice fed an FO diet. These results underline the importance of several dietary lipids as biological modulators of immune functions and their crucial role in the alteration of host natural resistance.According to present knowledge, many fatty acids contained in the diets of both animals and humans may exert a modulatory effect on immune functions (5, 12). It is generally assumed that the long-chain n-3 polyunsaturated fatty acids eicosapentaenoic acid (20:5[n-3]) and docosahexaenoic acid (DHA; 22: 6[n-3]), contained in fish oil, promote an immunosuppressive function. However, it has also been determined that monounsaturated fatty acids, such as oleic acid (derived from olive oil), rather than the other biological substances contained in this fat, cause an important reduction of numerous immune functions (21). Therefore, as a consequence of these events, many immunological functions, such as lymphocyte proliferation (15,24), cytokine production (15, 24), expression of cell surface molecules (20), natural killer (NK) cell activity (36), and phagocytosis (7), are modulated by the action of fatty acids. As a result, in recent years, numerous studies have indicated the potential role of several dietary lipids in the development of cancer or in the increase in resistance to tumors (9, 31). Similarly, unsaturated fatty acids have been applied in the resolution of inflammatory disorders associated with diseases characterized by an overreactivation of the immune system, such as rheumatoid arthritis (22, 23), psoriasis (2), and multiple sclerosis (1,18). However, despite the benefi...

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Section: Discussionmentioning

confidence: 98%

Relevance of Dietary Lipids as Modulators of Immune Functions in Cells Infected with Listeria monocytogenes

Puertollano

Pablo

Cienfuegos

2002

Clin Vaccine Immunol

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“…In this study, 18:33 increased serum antibodies to HEWL and the DTH reaction. Fish oils and 18:33 have been shown to increase antibody production in some [34,35] but not all studies [36,37]. Similarly, fish oils have been shown to increase the DTH reaction in some [38,39], but not all [40] studies.…”

Section: Discussionmentioning

confidence: 99%

Dietary 18:3ω3 influences immune function and the tissue fatty acid response to antigens and adjuvant

Bazinet¹,

Douglas²,

McMillan³

et al. 2004

Immunology Letters

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“…Indeed, one major drawback identified thus far of fish oil consumption has been an increased susceptibility to pathogenic infection (53). For instance, a fish oil-feeding study in mice showed an impairment in CTL cytotoxicity upon infection with influenza virus (54). Further work is clearly required in understanding the benefits and drawbacks of dietary supplementation with PUFAs.…”

Section: Physiological Implicationsmentioning

confidence: 99%

Immunosuppressive effects of polyunsaturated fatty acids on antigen presentation by human leukocyte antigen class I molecules

Shaikh

Edidin

2007

Journal of Lipid Research

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Dietary supplementation with polyunsaturated fatty acids (PUFAs) has immunosuppressive effects; however, the molecular targets of PUFAs and their mode of action remain unclear. One possible target is antigen presentation to T cells through the human leukocyte antigen (HLA) class I pathway. Here we show that incorporation of PUFAs lowers target cell susceptibility to lysis by effector T cells. Treatment of B lymphoblast targets with the v-6 PUFA arachidonic acid (AA) or v-3 docosahexaenoic acid lowered their susceptibility to lysis by alloreactive CD8 + T cells by z20-25%. HLA class I surface levels and their rate of endoplasmic reticulum (ER)-Golgi traffic were also reduced by PUFA treatment. Calibration experiments showed that the z15% reduction in surface HLA I was not sufficient to completely account for the decreased lysis. However, PUFAs significantly lowered antigen-presenting cell-T cell conjugate formation, by z30-40%. Taken together, our data show for the first time that an v-6 and an v-3 PUFA affect the HLA class I pathway of B lymphoblasts. Our findings suggest that elimination of self-and pathogen-derived peptides by effectors may be compromised by dietary PUFA supplementation. In addition, PUFA-mediated changes in ER-Golgi trafficking point to a new area of PUFA modulation of immune responses.-Shaikh, S. R., and M. Edidin. Immunosuppressive effects of polyunsaturated fatty acids on antigen presentation by human leukocyte antigen class I molecules. J. Lipid Res. 2007. 48: 127-138.

show abstract

Fish oil feeding enhances lymphocyte proliferation but impairs virus-specific T lymphocyte cytotoxicity in mice following challenge with influenza virus

Cited by 27 publications

References 28 publications

Relevance of Dietary Lipids as Modulators of Immune Functions in Cells Infected with Listeria monocytogenes

Relevance of Dietary Lipids as Modulators of Immune Functions in Cells Infected with Listeria monocytogenes

Dietary 18:3ω3 influences immune function and the tissue fatty acid response to antigens and adjuvant

Immunosuppressive effects of polyunsaturated fatty acids on antigen presentation by human leukocyte antigen class I molecules

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