Fish oil supplementation and physical exercise program: Distinct effects on different memory tasks

Rachetti, A.L.F.; Arida, Ricardo Mário; Patti, Camilla L.; Zanin, Karina A.; Fernades-Santos, L.; Frussa‐Filho, Roberto; Silva, S. Gomes da; Scorza, Fúlvio Alexandre; Cysneiros, Roberta Monterazzo

doi:10.1016/j.bbr.2012.09.048

Cited by 28 publications

(31 citation statements)

References 59 publications

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“…The exercise protocol used in the present study did not alter the performance of the trained group as compared to the sedentary control animals. Barnes et al (1991) and Rachetti et al (2012) found similar results, where trained rats did not show improvements in spatial and recognition memory compared to sedentary animals. These authors hypothesised that the absence of a training effect might be due to sedentary control animals achieving maximal performance during the memory tasks, thereby making it difficult to distinguish improvement in the performance of the trained groups.…”

Section: Discussionmentioning

confidence: 64%

Low‐intensity physical training recovers object recognition memory impairment in rats after early‐life induced Status epilepticus

Córdova

Loss

Oliveira

2013

Intl J of Devlp Neuroscience

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When it occurs early in life, Status epilepticus (SE) can cause behavioural and cognitive impairments in adulthood. Here, we evaluated the putative benefits of low-intensity treadmill training on long-standing cognitive impairment in rats submitted to SE early in life. Wistar rats were submitted to LiCl-pilocarpine-induced SE at P16. Animals from the trained group underwent a low-intensity treadmill protocol for 5 days per week for 4 weeks. At adulthood, rats subjected to early-life SE displayed impairment in long-term memory in an object recognition task, while the training protocol completely reversed this deficit. This result was associated with neither locomotor alterations nor changes in emotional behaviour; there were no differences between groups in the distance travelled, grooming or rearing in the open field test; there were also no differences between groups in the number of risk assessment, time spent in open arms in an elevated plus maze and number of entries into the open arms. These data suggest that physical exercise can ameliorate the long-standing recognition memory deficit induced by early-life SE, suggesting that it may be useful as a putative intervention for patients who suffered SE during infancy.

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Section: Discussionmentioning

confidence: 64%

Low‐intensity physical training recovers object recognition memory impairment in rats after early‐life induced Status epilepticus

Córdova

Loss

Oliveira

2013

Intl J of Devlp Neuroscience

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“…The Open‐field habituation test measures non‐associative learning ability through long‐term animal habituation. This is represented by decreased locomotor activity resulting from repeated exposure of the animal to the same environment, which is seen as a memory facilitation index (Rachetti et al, 2013). Our results showed that maternal consumption of cashew nuts induced habituation in the open field in the normolipidic group, similar to that found in the study by Rachetti et al (2013), in which the animals received diets with fish oil as a source of LC‐PUFA.…”

Section: Discussionmentioning

confidence: 99%

“…This is represented by decreased locomotor activity resulting from repeated exposure of the animal to the same environment, which is seen as a memory facilitation index (Rachetti et al, 2013). Our results showed that maternal consumption of cashew nuts induced habituation in the open field in the normolipidic group, similar to that found in the study by Rachetti et al (2013), in which the animals received diets with fish oil as a source of LC‐PUFA. However, this effect was not observed in the HL, corroborating the results obtained by Venna et al (2009), where animals treated with high LC‐PUFA concentration diet showed no significant difference in locomotor activity.…”

Section: Discussionmentioning

confidence: 99%

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Maternal intake of cashew nuts accelerates reflex maturation and facilitates memory in the offspring

Melo

Pereira

Sousa

et al. 2017

Intl J of Devlp Neuroscience

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Essential fatty acids, being indispensable during the stages of pregnancy, lactation and infancy influence the transmission of nerve impulses and brain function, and cashew nuts are a good source of these fatty acids. The objective of this study was to evaluate the effects of cashew nut consumption on reflex development, memory and profile of fatty acids of rat offspring treated during pregnancy and lactation. The animals were divided into three groups: Control (CONT), treated with 7% lipid derived from soybean oil; Normolipidic (NL) treated with 7% lipids derived from cashew nuts; and Hyperlipidic (HL) treated with 20% lipids derived from cashew nuts. Reflex ontogeny, Open-field habituation test and the Object Recognition Test (ORT) were assessed. The profile of fatty acids in the brain was carried out when the animals were zero, 21 and 60days old. Accelerated reflex maturation was observed in animals treated with cashew nuts (p<0.05). NL presented better memory in the Open-field habituation test; the NL and HL showed improvement of short-term memory in the ORT, but long term damage in HL (p<0.05). The results of the lipid profile of the brain at the end of the experiment showed an increase in levels of saturated fatty acids and less Docosahexaenoic acid (DHA) in animals of the HL. The data showed that maternal consumption of cashew nuts can accelerate reflex maturation and facilitate memory in offspring when offered in adequate quantities.

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“…The rats received one single dose of fish oil (FO, 85 mg/kg/d and 1 ml/250 g/d) or vehicle solution (V, 1 ml/250 g/d) daily during a period of 4 weeks, from Monday to Friday as previously described by Rachetti et al [22]. The fish oil capsules (PROEPA -Ache®), containing polyunsaturated fatty acids [docosahexaenoic acid (DHA; 120 mg/1 g) and eicosapentaenoic acid (EPA; 180 mg/1 g)] were dissolved in Cremophor (Sigma®) 0.009%, then in distilled water and administered via gavage.…”

Section: Fish Oil Supplementationmentioning

confidence: 99%

Can fish oil supplementation and physical training improve oxidative metabolism in aged rat hearts?

et al. 2015

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Fish oil supplementation and physical exercise program: Distinct effects on different memory tasks

Cited by 28 publications

References 59 publications

Low‐intensity physical training recovers object recognition memory impairment in rats after early‐life induced Status epilepticus

Low‐intensity physical training recovers object recognition memory impairment in rats after early‐life induced Status epilepticus

Maternal intake of cashew nuts accelerates reflex maturation and facilitates memory in the offspring

Can fish oil supplementation and physical training improve oxidative metabolism in aged rat hearts?

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