Fish-scale waste to portable bioactive discs: a sustainable platform for sensitive and reliable blood group analysis

Bollu, Tharun K.; Parimi, Divya S.; Bhatt, Chandra S.; Suresh, Anil K.

doi:10.1039/d2ay00128d

Cited by 7 publications

(3 citation statements)

References 51 publications

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“…Therefore, as an approach for sustainable advancement, fish scales have been transformed to valuable products such as television displays, piezoelectric nanogenerators, and biotemplate for spectroscopy 26 and are applied for heavy metal remediation, wound healing, and blood grouping. 27 In this work, simply by exposing the gold precursor to fish scales under extreme alkaline conditions and elevated temperatures, remarkably stable monodispersed AuNPs of ∼12 ± 4 nm are biosynthesized in a single step, devoid of additional surface modifications. Surprisingly, the exscalar AuNPs possessed high stabilities across encyclopedic laboratory routine biological, physicochemical, and physiological discrepancies, comparable to that of universal stabilizer, PEG-sorbed AuNPs (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

“…Fish scales are one such biowaste that are released in millions of tons globally, and if unutilized can lead to landfills, disposal expenses, environmental hazards, and pathogen propagation. Therefore, as an approach for sustainable advancement, fish scales have been transformed to valuable products such as television displays, piezoelectric nanogenerators, and biotemplate for spectroscopy and are applied for heavy metal remediation, wound healing, and blood grouping …”

Section: Introductionmentioning

confidence: 99%

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Sustainable Exscalar Monodispersed Gold Nanoparticles with Enhanced Dispersion Stability and Biocompatibility for Theragnostics

Bhatt,

Rajavel,

Parimi

et al. 2023

ACS Appl. Nano Mater.

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The stability and dispersity of gold nanoparticles (AuNPs) against various biological, physicochemical, and physiological transformations while retaining biocompatibility are fundamental for their myriad utilization in various theragnostic applications. Besides, it would be highly imperative if the AuNPs could be generated using environmentally sustainable procedures. Remarkably stable, monodispersed AuNPs with robustness against centrifugation, freeze-thawing, lyophilization, acids, bases, electrolytes, and polar solvents are generated by utilizing fish scale wastes. The AuNPs inherited self-integrity and dispersity across various clinically significant biological fluids including phosphate buffer saline, growth mediums, human blood serum, saliva, and urine. Human blood serum interactions revealed negligible protein corona consortium and biocompatibility with no hemolysis or cytotoxicity toward peripheral blood mononuclear cells. Astonishingly, endurance to all these biological, physicochemical, and physiological discrepancies was comparable to that of universal stabilizer thiolated polyethylene glycol (PEG) sorbed AuNPs. Such high stability and wide dispersity are attributed to the firm shielding of AuNPs by the oligopeptide fragments excreted from the scales, which also endowed AuNP functionalization to diverse drugs. Notably, our results develop a biogenic production of monodispersed AuNPs with natural sturdiness against harsh laboratory and clinical environments to substitute the plunged biocompatibility of PEG-Au sulfur chemisorption and PEG-Au physisorption approaches for various imaging and drug delivery applications.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sustainable Exscalar Monodispersed Gold Nanoparticles with Enhanced Dispersion Stability and Biocompatibility for Theragnostics

Bhatt,

Rajavel,

Parimi

et al. 2023

ACS Appl. Nano Mater.

Self Cite

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“…Recently, in the field of blood type detection, the fully automatic blood group analysis instrument has long become a hot topic [1][2][3]. With the continuous development of clinical science and in-depth and persistent research studies on blood type, there are various methods and forms of blood type detection.…”

Section: Introductionmentioning

confidence: 99%

Blood Group Interpretation Algorithm Based on Improved AlexNet

2023

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Traditional blood group interpretation technology has poor detection efficiency and interpretation accuracy in the face of complex conditions in clinical environments. In order to improve the interpretation accuracy of the automatic blood group interpretation system, the important role of deep learning in the blood group interpretation system was studied. Based on the AlexNet network model, this paper proposes an improved scheme because of its advantages in terms of speeding up the convergence training speed and enhancing the model’s generalizability. However, it still needs improvement in terms of blood group interpretation accuracy. The improved AlexNet network model proposed in this paper added an attention mechanism to the network structure, optimized the loss function in the training algorithm, and adjusted the learning rate attenuation function. The experiments showed that compared with the accuracy of the AlexNet model, its training effect was remarkable, with an accuracy of 96.9%—an increase of 3%. Moreover, the improved network model paid more attention to fine-grained classification, minimized the loss rate, and improved the accuracy of system interpretation.

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Sustainable golden nanoflowers grafted food-waste derived biotemplate for the direct SERS-detection of carcinogenic herbicides from agro-farms

Parimi,

Kumar,

Panneerselvam

et al. 2024

Materials Today Chemistry

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Fish-scale waste to portable bioactive discs: a sustainable platform for sensitive and reliable blood group analysis

Abstract: Blood group analysis has evolved from conventional “test-tube” to ingenious “lab-on-a-chip” micro/paper-fluidic devices for identifying blood phenotypes. Despite rapid and economical, fabrication of these devices require Whatman paper that is...

Cited by 7 publications

References 51 publications

Sustainable Exscalar Monodispersed Gold Nanoparticles with Enhanced Dispersion Stability and Biocompatibility for Theragnostics

Sustainable Exscalar Monodispersed Gold Nanoparticles with Enhanced Dispersion Stability and Biocompatibility for Theragnostics

Blood Group Interpretation Algorithm Based on Improved AlexNet

Sustainable golden nanoflowers grafted food-waste derived biotemplate for the direct SERS-detection of carcinogenic herbicides from agro-farms

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