Sub-Saharan Africa’s freshwater fisheries contribute significantly to the livelihoods and food security of millions of people within the region. However, freshwater fisheries are experiencing multiple anthropogenic stressors such as overfishing, illegal fishing, pollution, and climate change. There is a substantial body of literature on the effects of climate change on freshwater fisheries in Sub-Saharan Africa. This study reviews the existing literature and highlights the effects of climate change on freshwater fisheries, the adaptation strategies of fishery-dependent households in response to the effects, and fisheries’ management and mitigation efforts in the face of climate change. The general effects of climate change on freshwater environments include warming water temperatures, increased stratification, modified hydrological processes, and increased pollutants. These effects adversely affect the physiological processes of fish and the overall wellbeing of fishery-dependent people. To cope with the effects of fluctuating fishery resources due to climate change, fishery-dependent people have adopted several adaptation strategies including livelihood diversification, changing their fishing gear, increasing their fishing efforts, and targeting new species. Several management attempts have been made to enhance the sustainability of fishery resources, from local to regional levels. This study recommends the participation of the resource users in the formulation of policies aimed at promoting climate change adaptation and the resilience of freshwater fisheries for sustainable development.