Fishing for Quality in Environmental Analysis

Voogt, P. de; Haglund, Peter; Reutergårdh, Lars; Waem, Fredrik

doi:10.1021/ac00077a727

Cited by 7 publications

(3 citation statements)

References 24 publications

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“…The most frequently used analytical techniques for PCBs and OCPs are gas chromatography (GC) with electron‐capture detection (ECD)6, 7, 9, 14–16 and mass spectrometry (MS) with negative chemical ionization (NCI) 17. GC/NCI‐MS is a selective approach particularly suitable for confirming the presence of organochlorinated compounds in environmental samples.…”

Section: Introductionmentioning

confidence: 99%

Quantitative determination of endocrine- disrupting polychlorinated biphenyls and organochlorinated pesticides in human serum using gas chromatography with electron-capture detection and tandem mass spectrometry

Frenich¹,

Vidal²,

Frías³

et al. 2000

J. Mass Spectrom.

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A sensitive, selective and reliable procedure was developed and validated to determine organochlorinated compounds, which have endocrine-disrupting effects, in human serum. Target compounds were selected between polychlorinated biphenyls and organochlorinated pesticides. Sample workup consisted of (1) extraction of serum with organic solvents, (2) clean-up of the organic extract using acid treatment with H(2)SO(4), (3) elution of the cleaned-up extract through a liquid column chromatographic system and (4) analysis of the fraction eluted by gas chromatography with electron capture detection (ECD) and tandem mass spectrometry (MS/MS) detection. Performance characteristics, such as linearity, sensitivity, precision, accuracy and recovery, of both chromatographic methods were studied. The proposed analytical methodology was applied to determine the target compounds in serum samples from women living in agricultural areas of Almería (Spain). The results show the advantage of MS/MS over ECD in the analysis of real human serum samples where matrix interferences can be confused with target pesticides.

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Section: Introductionmentioning

confidence: 99%

Quantitative determination of endocrine- disrupting polychlorinated biphenyls and organochlorinated pesticides in human serum using gas chromatography with electron-capture detection and tandem mass spectrometry

Frenich¹,

Vidal²,

Frías³

et al. 2000

J. Mass Spectrom.

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“…fractionation methods for PCBs, PCDDs and PCDFs [1][2][3][4][5][6]. In the course of applying environmental samples of fish and avian eggs to the PGC column [3,4,6,[8][9][10][11][12][13]. These activated carbons have large (and to a PX-21 column), we noticed recovery surface areas and a large number and variety of polar problems for mono-ortho PCBs.…”

Section: Introductionmentioning

confidence: 99%

Loading capacity and chromatographic behavior of a porous graphitic carbon column for polychlorinated biphenyls

Echols¹,

Gale²,

Feltz³

et al. 1998

Journal of Chromatography A

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A porous graphitic carbon column (Hypercarb) was used for the fractionation of polychlorinated biphenyls (PCBs) into classes of 2-4 ortho chlorines, 1 ortho chlorine and 0 ortho chlorine congeners. A method was developed that combined the fractionation of PCBs, polychlorinated dibenzo-p-dioxins and dibenzofurans in a variety of biotic environmental samples. Many of these samples have high concentrations of PCBs which cause fractionation problems as adsorption sites on the graphitic surface are occupied. The loading capacity of the column for PCBs was determined by injecting up to 1 mg of total PCBs and monitoring changes in chromatographic behavior of tetra-/ di-ortho, mono-ortho and non-ortho substituted PCBs. Effective loading capacities were 1 mg for tetra-/ di-ortho PCBs, but only 3-5 mg for non-ortho PCBs and about 2 mg for mono-ortho PCBs. Loading capacity of the PGC column for environmental fish and avian egg samples was determined to depend on the mono-ortho and non-ortho PCB levels found in these samples.

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“…This makes it possible to analyze environmental samples using a GC-MS. Several trials have been proposed to apply this technique to food samples (Lee et al, 1991;Boer et al, 1992), but none of them are employed in official multiresidue quantitative methods (FDA, 1994c). Applicability of the technique to the food samples are not clear (Boer et al, 1992;Voogt et al, 1994). This paper describes a simple cleanup procedure used in conjunction with a capillary gas chromatography and a flame photometric and/or mass spectrometric detector for the simultaneous determination of organophosphorus pesticides (Figure 1) in fruits, vegetables, and grains.…”

Section: Introduction Omentioning

confidence: 99%

Multiresidue Procedures for the Determination of Pesticides in Food Using Capillary Gas Chromatographic, Flame Photometric, and Mass Spectrometric Techniques

Miyahara¹,

Okada²,

Takeda³

et al. 1994

J. Agric. Food Chem.

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Fishing for Quality in Environmental Analysis

Cited by 7 publications

References 24 publications

Quantitative determination of endocrine- disrupting polychlorinated biphenyls and organochlorinated pesticides in human serum using gas chromatography with electron-capture detection and tandem mass spectrometry

Quantitative determination of endocrine- disrupting polychlorinated biphenyls and organochlorinated pesticides in human serum using gas chromatography with electron-capture detection and tandem mass spectrometry

Loading capacity and chromatographic behavior of a porous graphitic carbon column for polychlorinated biphenyls

Multiresidue Procedures for the Determination of Pesticides in Food Using Capillary Gas Chromatographic, Flame Photometric, and Mass Spectrometric Techniques

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