2014
DOI: 10.17267/2596-3368dentistry.v5i1.329
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Fissuras Labiais E/Ou Palatinas Não Sindrômicas: Determinantes Ambientais E Genéticos.

Abstract: The nonsyndromic cleft lip and/or palate (NSCL/P) is a birth anomaly resulting from fusion defects of craniofacial processes. These changes have varied incidence and are more common in nonsyndromic form. The aim of this paper is conduct a literature review about NSCL/P, emphasizing the genetic aspects. In the critical analysis of the selected articles was founded that several genes and chromosomal regions have been associated with orofacial clefts in Genome Wide Association Studies (GWAS), like the genes IRF6,… Show more

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Cited by 6 publications
(8 citation statements)
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“…[8] However, even after several surgical procedures, small deformities, scars, or facial asymmetry may remain, causing a negative impact on facial esthetics, self-esteem, and social inclusion. [2][3][4][9][10][11] Thus, several studies report the perception by professionals, laypeople, parents, and patients about the esthetic result of the treatment of CLP. Lauris et al evaluated the esthetics of the facial profile of children rehabilitated with CLP, comparing the judgment of professionals related and unrelated to the rehabilitation of clefts and laypeople, and the results revealed that professionals related to cleft rehabilitation were kinder and those unrelated to cleft treatment were stricter about facial esthetics than laypeople.…”
Section: Literature Reviewmentioning
confidence: 99%
“…[8] However, even after several surgical procedures, small deformities, scars, or facial asymmetry may remain, causing a negative impact on facial esthetics, self-esteem, and social inclusion. [2][3][4][9][10][11] Thus, several studies report the perception by professionals, laypeople, parents, and patients about the esthetic result of the treatment of CLP. Lauris et al evaluated the esthetics of the facial profile of children rehabilitated with CLP, comparing the judgment of professionals related and unrelated to the rehabilitation of clefts and laypeople, and the results revealed that professionals related to cleft rehabilitation were kinder and those unrelated to cleft treatment were stricter about facial esthetics than laypeople.…”
Section: Literature Reviewmentioning
confidence: 99%
“…Orofacial clefts are the most common congenital malformations at birth [14]. Cleft lip/palate are defects characterized by incomplete closure of the upper lip with an alveolar cleft and/or incomplete closure of the hard palate [5] [13] [15]. The clefts in the midline of the upper lip or the lower lip, rare clefts and oblique facial clefts are not part of the set of cleft lip/palate [3].…”
Section: Non-syndromic Orofacial Cleftsmentioning
confidence: 99%
“…A etiologia das fendas orofaciais ainda é em grande parte desconhecida, no entanto, sabe-se que fatores genéticos e ambientais, além forte interferência de fatores étnicos, são contribuintes importantes para o desenvolvimento dessa anomalia (Borges et al, 2014, Schoenwolf et al, 2016.…”
Section: Introductionunclassified