Five Genome Sequences of Subspecies B1 Human Adenoviruses Associated with Acute Respiratory Disease

Dehghan, Shoaleh; Liu, Elizabeth B.; Seto, Jason; Torres, Sarah; Hudson, Nolan Ryan; Kajon, Adriana E.; Metzgar, David; Dyer, David W.; Chodosh, James; Jones, Mary Smith McCrory; Seto, Donald

doi:10.1128/jvi.06593-11

Cited by 22 publications

(14 citation statements)

References 13 publications

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“…HAdV were first isolated in 1953 as respiratory pathogens [5,6]. To date, over 60 types of HAdV have been identified and classified into seven species (A to G) [7][8][9][10][11][12][13][14]. Cases of severe infection, outbreaks in closed populations, and even epidemic outbreaks have been associated with the newly emerging or re-emergent types or variants [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Adenovirus infection in children with acute lower respiratory tract infections in Beijing, China, 2007 to 2012

et al. 2015

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BackgroundHuman adenoviruses (HAdV) play a significant role in pediatric respiratory tract infections. To date, over 60 types of HAdV have been identified. Here, HAdV types are characterized in children in the Beijing area with acute lower respiratory tract infections (ALRTIs) and the clinical features and laboratory findings of hospitalized HAdV-infected cases are described.MethodsRespiratory specimens were collected from pediatric patients with ALRTIs in the emergency department or from those admitted to Beijing Children’s Hospital between March 2007 and December 2012. Infections with common respiratory viruses were determined by PCR or RT-PCR. HAdV positive samples were further typed by PCR and sequencing.ResultsAmong 3356 patients with ALRTIs, 194 (5.8 %) were found to have HAdV infection. HAdV infection was primarily confined to children (88.35 %) less than 5 years of age. A total of 11 different types of HAdV were detected throughout the study period, with HAdV-B7 (49.0 %) and HAdV-B3 (26.3 %) as the most prevalent types, followed by HAdV-C2 (7.7 %) and HAdVC1 (4.6 %). Newly emerging and re-emergent types or variants, HAdV-B55 (n = 5), HAdV-C57 (n = 3), and HAdV-B14p1 (n = 1), were identified. Results also included the reported first case of co-infection with HAdV-C2 and HAdV-C57. Clinical entities of patients with single HAdV infection (n = 49) were similar to those with mixed HAdV/respiratory syncytial virus (RSV) infections (n = 41). Patients with HAdV-B7 infection had longer duration of fever and higher serum levels of muscle enzymes than HAdV-B3-infected patients.ConclusionsDuring the study period, HAdV-B7 and HAdV-B3 were the predominant types identified in pediatric ALRTIs. HAdV-B7 infection tends to have more severe clinical consequences. The presence of newly emerging types or variants and co-infection with different types of HAdV highlights the need for constant and close surveillance of HAdV infection.

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Section: Introductionmentioning

confidence: 99%

Adenovirus infection in children with acute lower respiratory tract infections in Beijing, China, 2007 to 2012

et al. 2015

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“…In addition, these types are categorized into seven species, Human mastadenovirus A to G according to their biophysical, biochemical, phylogenetic, and genetic characteristics . Particularly, 12 types have been categorized into HAdV‐B: HAdV‐3, ‐7, ‐11, ‐14, ‐16, ‐21, ‐34, ‐35, ‐50, ‐55, ‐66, and ‐68 . Moreover, HAdV‐B can be further divided into HAdV‐B subspecies 1 (HAdV‐3, ‐7, ‐16, ‐21, ‐50, ‐66, ‐68) and subspecies 2 (HAdV‐11, ‐14, ‐34, ‐35, ‐55) based on homology of the viral genomes, tissue tropism, and disease patterns …”

Section: Introductionmentioning

confidence: 99%

First isolation of a new type of human adenovirus (genotype 79), species Human mastadenovirus B (B2) from sewage water in Japan

Yoshitomi

Sera

González

et al. 2016

Journal of Medical Virology

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Human mastadenoviruses (HAdVs) are highly infectious viral pathogens that survive for prolonged periods in environmental waters. We monitored the presence of HAdVs in sewage waters between April 2014 and March 2015. A total of 27 adenoviral strains were detected in 75% (18/24 in occasion-base) of 24 wastewater collected samples. We identified the types of the strains as HAdV-C2 (n = 5), HAdV-A31 (5), HAdV-C1 (4), HAdV-B3 (4), HAdV-C5 (4), HAdV-B11 (2), P11H34F11 (2), and HAdV-D56 (1). The complete genome sequence of one P11H34F11 (strain T150125) was determined by next-generation sequencing and compared to other genome sequences of HAdV-B strains. The comparisons revealed evidence of a recombination event with breaking point in the hexon encoding region, which evidenced high similarity to HAdV-B34, while half of the rest of the genome showed similarity to HAdV-B11, including regions encoding fiber and E3 region proteins. The penton base encoding region seemed to be a recombinant product of HAdV-B14, -34; however, it was evidenced to be divergent to both as a novel type despite showing low bootstrap to support a new clade. We propose T150125 (P11H34F11) is a strain of a novel genotype, HAdV-79. These results support the usefulness of environmental surveillance approaches to monitor circulating HAdVs including novel types.

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“…To date, seven species including more than 68 genotypes have been characterized and defined by genomics and bioinformatics (Dehghan et al, 2012;Robinson et al, 2013). Specific species genotypes are often associated with particular clinical manifestations.…”

Section: Introductionmentioning

confidence: 99%

Mapping the epitope of neutralizing monoclonal antibodies against human adenovirus type 3

Tian

Liu

et al. 2015

Virus Research

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Five Genome Sequences of Subspecies B1 Human Adenoviruses Associated with Acute Respiratory Disease

Cited by 22 publications

References 13 publications

Adenovirus infection in children with acute lower respiratory tract infections in Beijing, China, 2007 to 2012

Adenovirus infection in children with acute lower respiratory tract infections in Beijing, China, 2007 to 2012

First isolation of a new type of human adenovirus (genotype 79), species Human mastadenovirus B (B2) from sewage water in Japan

Mapping the epitope of neutralizing monoclonal antibodies against human adenovirus type 3

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