Five-Membered Ring Systems

Yet, Larry

doi:10.1016/b978-0-08-099406-2.00009-1

Cited by 6 publications

References 400 publications

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Heterodi‐ (Fe, Pd/Pt) and Heterotrimetallic (Fe₂, Pd) Complexes Derived from 4‐(Ferrocenylmethyl)‐N‐(2‐methoxyethyl)‐3,5‐diphenylpyrazole as Potential Antitumoral Agents

et al. 2015

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The study of the reactivity of the pyrazole derivative 1‐[MeO(CH2)2]‐3,5‐Ph2‐4‐(CH2Fc)–(C3N2) (1, Fc = ferrocenyl) with Na2[PdCl4], Pd(OAc)2, and [MCl2(dmso)2] (M = Pd or Pt, dmso = dimethyl sulfoxide) has allowed us to isolate trans‐[Pd{κ‐N‐(1‐{MeO(CH2)2}‐3,5‐Ph2‐4‐{CH2Fc}–{C3N2})}2Cl2] (2), [Pd{κ2‐C,N(1‐{MeO(CH2)2}‐3‐{C6H4}‐5‐Ph‐{C3N2})}{κ‐N‐(1‐{MeO(CH2)2}‐3,5‐Ph2‐4‐{CH2Fc}–{C3N2})}Cl] (3), [Pd{κ2‐C,N(1‐{MeO(CH2)2}‐3‐{C6H4}‐4‐{CH2Fc}‐5‐Ph‐{C3N2})}Cl(PPh3)] (4), and the trans (5) and cis (6) isomers of [Pt{κ‐N‐(1‐{MeO(CH2)2}‐3,5‐Ph2‐4‐{CH2Fc}–{C3N2})}Cl2(dmso)]. Compound 1 acts as a N (in 2, 5, and 6) or (C,N)– donor ligand (in 4) and shows both binding modes in 3. The cytotoxic assessment of 1–6 against MCF7, MDA‐MB231 (breast), and HCT‐116 (colon) cancer cell lines reveal that (1) 1 is more potent than 1‐[MeO(CH2)2]‐3,5‐Ph2‐(C3HN2) (V), (2) 2–6 have cytotoxic activity, (3) 2 and 3 are less active than 4–6, and (4) 6 is the most potent compound against the three cancer cell lines.

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Heterodi‐ (Fe, Pd/Pt) and Heterotrimetallic (Fe₂, Pd) Complexes Derived from 4‐(Ferrocenylmethyl)‐N‐(2‐methoxyethyl)‐3,5‐diphenylpyrazole as Potential Antitumoral Agents

et al. 2015

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Diastereoselective Synthesis of Pyrazolo[1,2‐a][1,2,4]triazine Derivatives via Cross‐1,3‐dipolar Cyclizations of Azaoxyallyl Cations with N,N′‐Cyclic Azomethine Imines

Wang

et al. 2023

Eur J Org Chem

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Pyrazoles

Yet

2022

Comprehensive Heterocyclic Chemistry IV

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Five-Membered Ring Systems

Cited by 6 publications

References 400 publications

Heterodi‐ (Fe, Pd/Pt) and Heterotrimetallic (Fe₂, Pd) Complexes Derived from 4‐(Ferrocenylmethyl)‐N‐(2‐methoxyethyl)‐3,5‐diphenylpyrazole as Potential Antitumoral Agents

Heterodi‐ (Fe, Pd/Pt) and Heterotrimetallic (Fe₂, Pd) Complexes Derived from 4‐(Ferrocenylmethyl)‐N‐(2‐methoxyethyl)‐3,5‐diphenylpyrazole as Potential Antitumoral Agents

Diastereoselective Synthesis of Pyrazolo[1,2‐a][1,2,4]triazine Derivatives via Cross‐1,3‐dipolar Cyclizations of Azaoxyallyl Cations with N,N′‐Cyclic Azomethine Imines

Pyrazoles

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Five-Membered Ring Systems

Cited by 6 publications

References 400 publications

Heterodi‐ (Fe, Pd/Pt) and Heterotrimetallic (Fe2, Pd) Complexes Derived from 4‐(Ferrocenylmethyl)‐N‐(2‐methoxyethyl)‐3,5‐­diphenylpyrazole as Potential Antitumoral Agents

Heterodi‐ (Fe, Pd/Pt) and Heterotrimetallic (Fe2, Pd) Complexes Derived from 4‐(Ferrocenylmethyl)‐N‐(2‐methoxyethyl)‐3,5‐­diphenylpyrazole as Potential Antitumoral Agents

Diastereoselective Synthesis of Pyrazolo[1,2‐a][1,2,4]triazine Derivatives via Cross‐1,3‐dipolar Cyclizations of Azaoxyallyl Cations with N,N′‐Cyclic Azomethine Imines

Pyrazoles

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Heterodi‐ (Fe, Pd/Pt) and Heterotrimetallic (Fe₂, Pd) Complexes Derived from 4‐(Ferrocenylmethyl)‐N‐(2‐methoxyethyl)‐3,5‐diphenylpyrazole as Potential Antitumoral Agents

Heterodi‐ (Fe, Pd/Pt) and Heterotrimetallic (Fe₂, Pd) Complexes Derived from 4‐(Ferrocenylmethyl)‐N‐(2‐methoxyethyl)‐3,5‐diphenylpyrazole as Potential Antitumoral Agents