Five-Year Experience of Vitamin E–Diffused Highly Cross-Linked Polyethylene Wear in Total Hip Arthroplasty Assessed by Radiostereometric Analysis

Nebergall, Audrey; Troelsen, Anders; Rubash, Harry E.; Malchau, Henrik; Rolfson, Ola; Greene, Meridith E.

doi:10.1016/j.arth.2015.12.023

Cited by 30 publications

(20 citation statements)

References 34 publications

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“…As HXLPE/VitE is a relatively new material in orthopedic surgery, studies on its wear properties with longer follow-up periods are still limited (Nebergall et al 2016, Shareghi et al 2017, Galea et al 2019. Our initial 3-year data showed less wear with HXLPE/VitE, which may prevent osteolysis, implant loosening, and eventually revision surgery (Rochcongar et al 2018).…”

mentioning

confidence: 81%

Reduced wear in vitamin E-infused highly cross-linked polyethylene cups: 5-year results of a randomized controlled trial

et al. 2020

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Background and purpose — Vitamin E-infused polyethylene is a relatively new material in joint arthroplasty; there are no long-term reports, and only few mid-term results. Using radiostereometric analysis (RSA), we primarily determined whether vitamin E-infused highly cross-linked polyethylene (HXLPE/VitE) acetabular cups show less wear than ultra-high molecular weight polyethylene (UHMWPE) acetabular cups at 5 years after total hip arthroplasty (THA). We also assessed whether wear rates correlate with increasing cup inclination angles or cup sizes. Patients and methods — This is a 5-year follow-up of our previously reported randomized controlled trial of 62 patients with 3 years’ follow-up, who received THA with either an HXLPE/VitE or a UHMWPE acetabular cup. At 5 years, 40 patients were analyzed (22 in the HXLPE/VitE and 18 in the UHMWPE group). Results — HXLPE/VitE cups continued to show less cumulative femoral head penetration than UHMWPE cups (HXLPE/VitE: 0.24 mm, UHMWPE: 0.45 mm; p < 0.001). Distribution of wear was also more even with HXLPE/VitE cups than with UHMWPE cups (p = 0.002). Moreover, the difference in PE wear between 1 and 5 years in both groups showed no statistically significant correlation with increasing cup inclination angles or cup sizes. Finally, no osteolysis and implant loosening occurred, and no revision surgeries were required. Interpretation — Wear rates continue to be lower in HXLPE/VitE cups than in UHMWPE cups at 5 years of follow-up without correlation with increasing cup inclination angles or cup sizes. Finally, HXLPE/VitE cups may have the potential to prevent osteolysis and implant loosening.

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confidence: 81%

Reduced wear in vitamin E-infused highly cross-linked polyethylene cups: 5-year results of a randomized controlled trial

et al. 2020

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“…However, one study reporting head penetration into vitamin E doped highly crosslinked liners at five years demonstrated less wear compared to that previously reported for 1st generation highly crosslinked PE, at the same interval of five years. Further, the study demonstrated that, after settling of the liners in the early period, no significant head penetration occurred from two- to five-year follow-up and the authors remarked that, overall, the wear observed in the study was well below that at which osteolysis becomes a serious concern [ 153 ].…”

Section: 2nd Generation Highly Crosslinked Polyethylenementioning

confidence: 99%

Ultra-High Molecular Weight Polyethylene: Influence of the Chemical, Physical and Mechanical Properties on the Wear Behavior. A Review

et al. 2017

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Ultra-high molecular weight polyethylene (UHMWPE) is the most common bearing material in total joint arthroplasty due to its unique combination of superior mechanical properties and wear resistance over other polymers. A great deal of research in recent decades has focused on further improving its performances, in order to provide durable implants in young and active patients. From “historical”, gamma-air sterilized polyethylenes, to the so-called first and second generation of highly crosslinked materials, a variety of different formulations have progressively appeared in the market. This paper reviews the structure–properties relationship of these materials, with a particular emphasis on the in vitro and in vivo wear performances, through an analysis of the existing literature.

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“…13 There have been a few clinical trials presenting 2-and 3-year results, [14][15][16] and 2 studies have presented 5-year results. 17,18 To our knowledge, no long-term clinical follow-up studies have been published, and thus, the aim of this study was to present 6-year results from the initial RCT.…”

Section: Introductionmentioning

confidence: 99%

Low wear rate at 6-year follow-up of vitamin E-infused cross-linked polyethylene: a randomised trial using 32- and 36-mm heads

et al. 2018

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Five-Year Experience of Vitamin E–Diffused Highly Cross-Linked Polyethylene Wear in Total Hip Arthroplasty Assessed by Radiostereometric Analysis

Cited by 30 publications

References 34 publications

Reduced wear in vitamin E-infused highly cross-linked polyethylene cups: 5-year results of a randomized controlled trial

Reduced wear in vitamin E-infused highly cross-linked polyethylene cups: 5-year results of a randomized controlled trial

Ultra-High Molecular Weight Polyethylene: Influence of the Chemical, Physical and Mechanical Properties on the Wear Behavior. A Review

Low wear rate at 6-year follow-up of vitamin E-infused cross-linked polyethylene: a randomised trial using 32- and 36-mm heads

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