Five-Year Follow Up of Physical Growth and Thyroid Hormone Levels in Infants With Congenital Hypothyroidism

Lotfi, M H; Pordanjani, Sajjad Rahimi; Akhondi-Meybodi, Mohsen; Rabei, Azar; Ordooei, Mahtab; Pourmohammadi, Behrad

doi:10.5812/ijp.5690

Cited by 4 publications

(5 citation statements)

References 21 publications

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“…According to a study conducted in Japan on 2,341 children with CH, both CH and healthy children had normal height growth ( 33 ). Lotfi et al found no significant difference between the growth patterns of CH and healthy children after five years of age in terms of height, weight, and head circumference ( 34 ).…”

Section: Discussionmentioning

confidence: 99%

Physical Development at School Entry in Children with Congenital Hypothyroidism Diagnosed by the National Program of Newborn Screening in Iran

Yarahmadi

Nikkhoo

Parvizi

et al. 2022

Int J Endocrinol Metab

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Background: The newborn screening program for diagnosing and treating children with congenital hypothyroidism (CH) in Iran was established in 2004. Objectives: This study aimed to evaluate the national program’s success in maintaining the physical development and anthropometric indexes of children with CH. Methods: This historical cohort study was carried out in five provinces located in five different geographical regions of Iran. The anthropometric indexes, including weight, height, and head circumference of 240 children diagnosed with transient congenital hypothyroidism (TCH) (n = 131) and permanent congenital hypothyroidism (PCH) (n = 109) were measured and compared with those of 240 healthy children aged six. Results: Mean ± standard deviation (SD) of weight, height, and head circumference of children with CH aged six were 20304.8 ± 4457.9 g, 115.6 ± 5.9 cm, and 50.8 ± 1.7 cm, respectively. Mean ± SD of height (116.7 ± 6.1 cm) and head circumference (51.1 ± 1.7 cm) in the control (healthy) group were significantly higher than those of the CH children group (P < 0.05). Mean ± SD weight in the control group (20741.2 ± 4337.3 g) was higher than that in the CH group (20304.8 ± 4457.9 g). However, the difference was not statistically significant (P = 0.3). No significant difference was observed between TCH and PCH children in the subgroup analysis (P > 0.05). Conclusions: Although the mean of anthropometric indexes in CH patients was slightly lower than that in healthy children aged six, the difference between the two groups was insignificant. The physical development of children with CH was evaluated as good. Our results suggested that the newborn screening program for identifying and treating children with CH in Iran may have improved the growth outcomes.

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Section: Discussionmentioning

confidence: 99%

Physical Development at School Entry in Children with Congenital Hypothyroidism Diagnosed by the National Program of Newborn Screening in Iran

Yarahmadi

Nikkhoo

Parvizi

et al. 2022

Int J Endocrinol Metab

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“…The onset and completion of puberty and achievement of adult height have been found to be normal in these children. [3][4][5] However, delayed diagnosis of congenital hypothyroidism or acquired juvenile hypothyroidism leads to growth retardation. There is a slowing of growth with a downward deviation from the standard growth curve.…”

Section: Discussionmentioning

confidence: 99%

“…Most studies have assessed the growth of infants with congenital hypothyroidism detected by neonatal screening. [3][4][5] Few studies have been done to assess the catch-up growth in older children with hypothyroidism. Therefore, author undertook this study to assess the catch-up growth in children with primary hypothyroidism following treatment with thyroxine.…”

Section: Introductionmentioning

confidence: 99%

Effect of thyroxine on initial catch-up growth in children with hypothyroidism

Patel¹,

Trivedi²

2019

Int J Contemp Pediatr

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Background: Hypothyroidism is a common endocrinal cause of growth retardation in children. Following adequate treatment with thyroxine, growth resumes at an accelerated rate which is known as catch-up growth. There are few observational studies from India on the growth parameters following treatment with thyroxine in children with hypothyroidism.Methods: A retrospective study was done in children aged 2-10 years who were newly diagnosed cases of primary hypothyroidism [Total serum Thyroxine (T4) levels <5 µg/dl and serum Thyroid Stimulating Hormone (TSH) levels ˃15 µU/ml] and treated with oral thyroxine to attain euthyroid state. Height measured before starting treatment and at the time of follow up visits was noted, the Height Standard Deviation Scores (HSDS) were calculated. The effect of thyroxine on linear growth was studied.Results: There were 23 children who were diagnosed as having primary hypothyroidism of whom 16(69.6%) were females and 7(30.4%) were males. The mean age of the children studied was 7.3±2.3 years. The mean dose of thyroxine required to maintain euthyroid status was 4.6±2.2 µg/kg/day. Mean duration of follow up was 13.7±2.4 months. The initial HSDS was - 2.31±0.9 which improved to a final value of - 1.7±0.76 (ΔHSDS0.61, p value <0.0001). Mean height velocity was 8.1 cms/year.Conclusions: Following adequate thyroxine replacement therapy catch-up growth occurs and increased growth velocity leads to partial regain of height deficit in the first couple of years of treatment.

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“…Thyroid hemiagenesis (THA) is a rare congenital developmental abnormality, where one of the thyroid lobes fails to develop (1). The etiology of THA and other thyroid dysgenesis (TD) is largely unknown (2,3). Thus, factors that disturb the process by influencing the lobulation of the thyroid anlage are yet to be unraveled (4,5).…”

Section: Introductionmentioning

confidence: 99%

Analysis of the Seasonality of Births in a Large Cohort of Patients with Thyroid Hemiagenesis - A Preliminary Study

et al. 2018

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Objectives: Thyroid hemiagenesis (THA) is a congenital anomaly of unknown origin. The aim of this study was to assess for the first time whether there is any seasonality in the date of birth of patients with THA in comparison to general population. Methods: The studied group consisted of 105 patients with THA. The control data regarding total live births in Poland were derived from the Polish Statistical Annals (n = 2 421 384). Both groups were subdivided according to the month of birth, season of birth and quarter of the year. Results: Analysis of the months of birth revealed that patients with THA were born significantly less often in October than control subjects (P = 0.0217). Although a trend is observed, that more patients with THA were born in the 1st quarter of the year and in winter, while THA patients were less often born in autumn or in 4th quarter of the year, the difference did not reach statistical significance. Conclusions: Month of birth may exert some effect on the risk of developing THA. Studies on larger cohorts are needed to confirm the observation. The results suggest a potential modifying effect of environmental factors in the pathogenesis of THA.

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Five-Year Follow Up of Physical Growth and Thyroid Hormone Levels in Infants With Congenital Hypothyroidism

Cited by 4 publications

References 21 publications

Physical Development at School Entry in Children with Congenital Hypothyroidism Diagnosed by the National Program of Newborn Screening in Iran

Physical Development at School Entry in Children with Congenital Hypothyroidism Diagnosed by the National Program of Newborn Screening in Iran

Effect of thyroxine on initial catch-up growth in children with hypothyroidism

Analysis of the Seasonality of Births in a Large Cohort of Patients with Thyroid Hemiagenesis - A Preliminary Study

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