Five-Year Outcomes of Patients With Mitral Structural Valve Deterioration Treated With Transcatheter Valve in Valve Implantation – A Single Center Prospective Registry

Pravda, Nili Schamroth; Mishaev, Raffael; Levi, Amos; Witberg, Guy; Shapira, Yaron; Orvin, Katia; Barkan, Yeela Talmor; Hamdan, Ashraf; Sharoni, Ram; Perl, Leor; Sagie, Alexander; Assa, Hana Vaknin; Kornowski, Ran; Codner, Pablo

doi:10.3389/fcvm.2022.883242

Cited by 4 publications

(1 citation statement)

References 15 publications

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“…Following the development of transcatheter technologies in aortic valve replacement, transcatheter mitral valve-in-valve or valve-in-ring implantation has recently also been rapidly developing as an alternative to conventional surgical mitral valve redo procedures ( 16 , 17 ). To date, the outcomes of both redo SMVR and TMVR therapy have been reported ( 5 , 18 ). However, comparisons between redo SMVR and TMVR are limited.…”

Section: Discussionmentioning

confidence: 99%

Transcatheter mitral valve replacement versus redo surgery for mitral prosthesis failure: A systematic review and meta-analysis

Zhou

Chen

et al. 2023

Front. Cardiovasc. Med.

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BackgroundTranscatheter mitral valve replacement (TMVR) has emerged as an alternative to redo surgery. TMVR compared with redo surgical mitral valve replacement (SMVR) in patients with mitral prosthesis failure remains limited. In this study, we performed a meta-analysis to assess the outcomes of TMVR (including valve-in-valve and valve-in-ring) versus redo surgery for mitral prosthesis failure.MethodsWe comprehensively searched the PubMed, Embase, and Cochrane library databases according to predetermined inclusion and exclusion criteria, and then we extracted data. We compared the outcomes of TMVR and redo SMVR for mitral prosthesis failure in terms of the in-hospital mortality, stroke, renal dysfunction, vascular complication, pacemaker implantation, exploration for bleeding, paravalvular leak, mean mitral valve gradient, 30-day mortality, and 1-year mortality.ResultsNine retrospective cohort studies and a total of 3,038 patients were included in this analysis. Compared with redo SMVR for mitral prosthesis failure, TMVR was associated with lower in-hospital mortality [odds ratios (OR): 0.44; 95% confidence interval (CI): 0.30–0.64; P < 0.001], stroke (OR: 0.44; 95% CI: 0.29–0.67; P = 0.0001), renal dysfunction (OR: 0.52; 95% CI: 0.37–0.75; P = 0.0003), vascular complication (OR: 0.58; 95% CI: 0.43–0.78; P = 0.004), pacemaker implantation (OR: 0.23; 95% CI: 0.15–0.36; P < 0.00001), and exploration for bleeding (OR: 0.24; 95% CI: 0.06–0.96; P = 0.04). Conversely, redo SMVR had lower paravalvular leak (OR: 22.12; 95% CI: 2.81–174.16; P = 0.003). There was no difference in mean mitral valve gradient (MD: 0.04; 95% CI: −0.47 to 0.55; P = 0.87), 30-day mortality (OR: 0.65; 95% CI: 0.36–1.17; P = 0.15), and 1-year mortality (OR: 0.96; 95% CI: 0.63–1.45; P = 0.84).ConclusionIn patients with mitral prosthesis failure, TMVR is associated with lower in-hospital mortality and lower occurrence of postoperative complications, except for paravalvular leak. TMVR offers a viable alternative to the conventional redo surgery in selected patients.

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Section: Discussionmentioning

confidence: 99%

Transcatheter mitral valve replacement versus redo surgery for mitral prosthesis failure: A systematic review and meta-analysis

Zhou

Chen

et al. 2023

Front. Cardiovasc. Med.

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Clinical Outcomes of Transcatheter Mitral Valve‐In‐Valve and Valve‐In‐Ring Implantation: A Systematic Review and Meta‐Analysis

Fong,

Koh,

Saw

et al. 2024

Cathet Cardio Intervent

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BackgroundTranscatheter valve‐in‐valve (VIV) or valve‐in‐ring (VIR) therapies for degenerated mitral bioprosthetic valves and rings are still evolving. We aimed to characterize short‐ and long‐term outcomes of these procedures.MethodsAn electronic literature search was conducted to retrieve articles describing mitral VIV or VIR implantation with at least 10 patients. Meta‐analysis of proportions was carried out for 30‐day or in‐hospital outcomes of mortality, stroke, major bleeding, transfusion, acute kidney injury, procedural success, valve embolization, paravalvular leak, pacemaker implantation, and hospital stay. Individual patient data meta‐analysis using Kaplan‐Meier curve reconstruction was used to estimate long‐term mortality of VIV, VIR and redo surgical mitral valve replacement (SMVR).ResultsWe analyzed 34 studies (7047 patients). Pooled procedural success was 94.8% in VIV and 80.5% in VIR. Pooled short‐term mortality and stroke risk was 6.4% and 1.9% respectively in VIV, 9.1% and 1.6% respectively in VIR, and 8.4% and 5.5% respectively in SMVR.ConclusionsThis study provides prognostic information on clinical outcomes for redo SMVR and transcatheter mitral VIV and VIR implantation.

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Transseptal vs Transapical Transcatheter Mitral Valve-in-Valve and Valve-in-Ring Implantation: A Systematic Review and Meta-Analysis

Al-Tawil

Butt

Reap

et al. 2023

Current Problems in Cardiology

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Five-Year Outcomes of Patients With Mitral Structural Valve Deterioration Treated With Transcatheter Valve in Valve Implantation – A Single Center Prospective Registry

Cited by 4 publications

References 15 publications

Transcatheter mitral valve replacement versus redo surgery for mitral prosthesis failure: A systematic review and meta-analysis

Transcatheter mitral valve replacement versus redo surgery for mitral prosthesis failure: A systematic review and meta-analysis

Clinical Outcomes of Transcatheter Mitral Valve‐In‐Valve and Valve‐In‐Ring Implantation: A Systematic Review and Meta‐Analysis

Transseptal vs Transapical Transcatheter Mitral Valve-in-Valve and Valve-in-Ring Implantation: A Systematic Review and Meta-Analysis

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