Fixation in Patients with Juvenile Macular Disease

Macedo, António Filipe; Nascimento, Sérgio M. C.; Gomes, Alexandra; Puga, André Teixeira

doi:10.1097/opx.0b013e3181559beb

Cited by 17 publications

(15 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This study however used a much lower temporal resolution and might have been unable to accurately filter out intrusive saccades nor detect slow drift. Our results align with a more recent study that also showed decreased fixation stability in patients with JMD [51]. Given results from our previous study [29] it is likely that diminished visual acuity in the periphery contributes to this decreased fixational control.…”

Section: Discussionsupporting

confidence: 92%

Decreased Fixation Stability of the Preferred Retinal Location in Juvenile Macular Degeneration

et al. 2014

View full text Add to dashboard Cite

Macular degeneration is the main cause for diminished visual acuity in the elderly. The juvenile form of macular degeneration has equally detrimental consequences on foveal vision. To compensate for loss of foveal vision most patients with macular degeneration adopt an eccentric preferred retinal location that takes over tasks normally performed by the healthy fovea. It is unclear however, whether the preferred retinal locus also develops properties typical for foveal vision. Here, we investigated whether the fixation characteristics of the preferred retinal locus resemble those of the healthy fovea. For this purpose, we used the fixation-offset paradigm and tracked eye-position using a high spatial and temporal resolution infrared eye-tracker. The fixation-offset paradigm measures release from fixation under different fixation conditions and has been shown useful to distinguish between foveal and non-foveal fixation. We measured eye-movements in nine healthy age-matched controls and five patients with juvenile macular degeneration. In addition, we performed a simulation with the same task in a group of five healthy controls. Our results show that the preferred retinal locus does not adopt a foveal type of fixation but instead drifts further away from its original fixation and has overall increased fixation instability. Furthermore, the fixation instability is most pronounced in low frequency eye-movements representing a slow drift from fixation. We argue that the increased fixation instability cannot be attributed to fixation under an unnatural angle. Instead, diminished visual acuity in the periphery causes reduced oculomotor control and results in increased fixation instability.

show abstract

Section: Discussionsupporting

confidence: 92%

Decreased Fixation Stability of the Preferred Retinal Location in Juvenile Macular Degeneration

et al. 2014

View full text Add to dashboard Cite

show abstract

“…The existence of the non-foveal or eccentric PRLs in STGD1 has been known for many years, but the exact sequence of the retinal degenerative processes contributing to its development and location still remains unclear [13–14]. Patients with age-related macular disease (AMD) usually develop an eccentric PRL that is typically located at the edge of the MA in an area of relatively healthy retina [15] and some authors hypothesize that different cortical adaptation mechanisms may be active in AMD and juvenile forms of macular degeneration [11].…”

Section: Introductionmentioning

confidence: 99%

Multimodal analysis of the Preferred Retinal Location and the Transition Zone in patients with Stargardt Disease

Verdina

Greenstein

Sodi

et al. 2017

Graefes Arch Clin Exp Ophthalmol

View full text Add to dashboard Cite

Purpose To investigate morpho-functional features of the preferred retinal location (PRL) and the transition zone (TZ) in a series of patients with recessive Stargardt disease (STGD1). Methods Fifty-two STGD1 patients with at least one ABCA4 mutation, atrophy of the central macula (MA) and an eccentric PRL were recruited for the study. Microperimetry, fundus autofluorescence (FAF), spectral-domain optical coherence tomography (SD-OCT) were performed. The location and stability of the PRL along with the associated FAF pattern and visual sensitivities were determined and compared to the underlying retinal structure. Results The mean visual sensitivity of the PRLs for the 52 eyes was 10.76 +/− 3.70 dB. For the majority of eyes, PRLs were associated with intact ellipsoid zone (EZ) bands and qualitatively normal FAF patterns. In 17 eyes (32.7%) the eccentric PRL was located at the edge of the MA. In 35 eyes (67.3%) it was located at varying distances from the border of the MA with a TZ between the PRL and the MA. The TZ was associated with decreased sensitivity values (5.92 +/− 4.69 dB) compared to PRLs (p<0.05), with absence/disruption of the EZ band and abnormal FAF patterns (hyper or hypo-autofluorescence). Conclusions In STGD1 eccentric PRLs are located away from the border of MA and associated with intact EZ bands and normal FAF. The TZ is characterized by structural and functional abnormalities. The results of multimodal imaging of the PRL and TZ suggest a possible sequence of retinal and functional changes with disease progression that may help in the planning of future therapies: RPE dysfunction appears to be the primary event leading to photoreceptor degeneration and then to RPE loss.

show abstract

“…Individuals with central scotomas and amblyopia show enlarged BCEAs. [19][20][21] In subjects with IN, there is a positive correlation between foveation duration and visual acuity. 3,22 Training-induced acuity improvements might thus be related to prolonged foveation periods after training.…”

mentioning

confidence: 99%

Perceptual Learning in Children With Infantile Nystagmus: Effects on 2D Oculomotor Behavior

Huurneman

Boonstra

Goossens

2016

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

Fixation in Patients with Juvenile Macular Disease

Cited by 17 publications

References 24 publications

Decreased Fixation Stability of the Preferred Retinal Location in Juvenile Macular Degeneration

Decreased Fixation Stability of the Preferred Retinal Location in Juvenile Macular Degeneration

Multimodal analysis of the Preferred Retinal Location and the Transition Zone in patients with Stargardt Disease

Perceptual Learning in Children With Infantile Nystagmus: Effects on 2D Oculomotor Behavior

Contact Info

Product

Resources

About