2017
DOI: 10.3390/bioengineering4010005
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Fixation Release and the Bone Bandaid: A New Bone Fixation Device Paradigm

Abstract: The current gold standard of care for mandibular segmental defeat reconstruction is the use of Ti-6Al-4V immobilization hardware and fibular double barrel graft. This method is often successful immediately at restoring mandible function, however the highly stiff fixation hardware causes stress shielding of the grafted bone and stress concentration in the fixation device over time which can lead to fixation device failure and revision surgery. The purpose of reconstructive surgery could be to create normal stre… Show more

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Cited by 19 publications
(10 citation statements)
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“…Currently, titanium alloys such as Ti-6Al-4V are the most used for the manufacture of orthopedic fixing devices and bone implants due to their excellent biocompatibility and high mechanical resistance [ 3 ]. However, they prevent the bone from being subjected to the required mechanical loadings [ 4 ]. Indeed, while natural bone has a modulus ranging between 8 to 25 GPa, metals have a modulus of 110–210 GPa, which results in the load being imparted onto the device rather than the bone which then causes a localized decrease in bone mineral density [ 5 ].…”
Section: Introductionmentioning
confidence: 99%
“…Currently, titanium alloys such as Ti-6Al-4V are the most used for the manufacture of orthopedic fixing devices and bone implants due to their excellent biocompatibility and high mechanical resistance [ 3 ]. However, they prevent the bone from being subjected to the required mechanical loadings [ 4 ]. Indeed, while natural bone has a modulus ranging between 8 to 25 GPa, metals have a modulus of 110–210 GPa, which results in the load being imparted onto the device rather than the bone which then causes a localized decrease in bone mineral density [ 5 ].…”
Section: Introductionmentioning
confidence: 99%
“…The interactions between the hinge/AFO and hinge/springs were considered as “tie”, and a “self-contact interaction” was considered for the spring. The material properties of hinge, AFO, and springs are summarized in Table 2 [ 11 , 25 , 28 , 38 ]. As shown in Figure 6 , in the simulation, to obtain the distribution of von Mises’ stress in the maximum plantar flexion, an external moment of 0.62 N¡m/kg was applied to the center of rotation of the hinge.…”
Section: Methodsmentioning
confidence: 99%
“…As a solution, our group has proposed and introduced a new generation of bone fixation plates that are stiffness matched to the bone tissue and are fabricated via additive manufacturing [2][3][4][5][6][7]. Stiffness modulation and the matching is achieved via replacing the Ti64 with Nitinol, as well as incorporating engineered porosity to the bone fixation plates.…”
Section: Introductionmentioning
confidence: 99%