Flagyl (8823 R.P.) in the Treatment of Trichomoniasis

Nicol, C. S.; Barrow, J. Gordon; Redmond, Andrew

doi:10.1136/sti.36.3.152

Cited by 9 publications

(7 citation statements)

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“…Several independent studies quickly confirmed the imposing effectivity of metronidazole, then already being sold under its brand name Flagyl®, against T . vaginalis (Durel et al 1960; Nicol et al 1960; Rodin et al 1960). Soon thereafter, the suitability of metronidazole for the treatment of other microaerophilic parasites, i.e.…”

Section: Introductionmentioning

confidence: 99%

A review on metronidazole: an old warhorse in antimicrobial chemotherapy

2017

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The 5-nitroimidazole drug metronidazole has remained the drug of choice in the treatment of anaerobic infections, parasitic as well as bacterial, ever since its development in 1959. In contrast to most other antimicrobials, it has a pleiotropic mode of action and reacts with a large number of molecules. Importantly, metronidazole, which is strictly speaking a prodrug, needs to be reduced at its nitro group in order to become toxic. Reduction of metronidazole, however, only takes place under very low concentrations of oxygen, explaining why metronidazole is exclusively toxic to microaerophilic and anaerobic microorganisms. In general, resistance rates amongst the pathogens treated with metronidazole have remained low until the present day. Nevertheless, metronidazole resistance does occur, and for the treatment of some pathogens, especially Helicobacter pylori, metronidazole has become almost useless in some parts of the world. This review will give an account on the current status of research on metronidazole's mode of action, metronidazole resistance in eukaryotes and prokaryotes, and on other 5-nitroimidazoles in use.

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Section: Introductionmentioning

confidence: 99%

A review on metronidazole: an old warhorse in antimicrobial chemotherapy

2017

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“…Cure rates in women of over 80 per cent, have been reported by several observers (Rodin, King, Nicol, and Barrow, 1960;Nicol, Barrow, and Redmond, 1960; Watt and Jennison, 1962). Even higher cure rates have been claimed in cases of trichomonal urethritis in men (Durel, Roiron, Siboulet, and Borel, 1960; Rodin and others, 1960; Sylvestre, Belanger, and Gallai, 1960).…”

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confidence: 78%

Treatment of trichomonal prostatitis with metronidazole.

Catterall¹

1965

Sexually Transmitted Infections

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The treatment of trichomonal infestations of the genito-urinary tracts of both men and women has been greatly improved since the introduction of metronidazole in 1959. Cure rates in women of over 80 per cent, have been reported by several observers (Rodin, King, Nicol, and Barrow, 1960;Nicol, Barrow, and Redmond, 1960; Watt and Jennison, 1962). Even higher cure rates have been claimed in cases of trichomonal urethritis in men (Durel, Roiron, Siboulet, and Borel, 1960; Rodin and others, 1960; Sylvestre, Belanger, and Gallai, 1960).The incidence of trichomonal prostatitis is unknown. As examination of the prostatic secretion is not always carried out in the male sexual contacts of women with trichomonal vaginitis or in men with symptoms of disease of the lower genito-urinary tract, the true frequency of the condition is likely to remain undetermined. Patients and MethodThe patients in this series were all men who attended the department of venereology or were seen in private practice either because their sexual partners had been Found to have trichomonal vaginitis or because they had undiagnosed symptoms referrable to the lower genitourinary tract. Their ages ranged from 17 to 74 years.In addition to physical examination, investigation included an urethral scrape and culture, microscopical and cultural examination of the centrifuged deposit of urine, prostatic massage, and microscopical and cultural examination of the prostatic secretions, frequently on more than one occasion. ResultsTrichomonas vaginalis was demonstrated in the prostatic secretions in 34 patients. Symptoms were entirely absent in 27 patients, but six complained of vague discomfort or pain in the perineum, the penis, or both. One patient complained of frequency of micturition. A past history of urethritis was obtained from nineteen of the patients and in six of them no investigations had been performed or treatment given and the discharge had cleared up spontaneously. Trichomonal vaginitis was found in the sexual partners of ten of the men.The diagnosis was made by demonstrating Trichomonas vaginalis on microscopical examination and growing it in cultures in eighteen of the patients. The parasite was found microscopically but was not grown in cultures in nine and was grown in cultures but not demonstrated microscopically in seven patients.Treatment consisted of oral metronidazole, 200 mg. three times daily after meals for 7 days. Most of the patients were followed for 3 months and repeated tests were performed on the prostatic secretions and the urine to establish and confirm cure. Thirty of the patients (88 per cent.) were considered to have been cured by a single course of treatment and were discharged from follow-up after 3 months. In two patients (both of whom denied intercourse or the possibility of re-infection), the parasite reappeared in the prostatic secretions during the period of observation but in both cases it disappeared after a second course of metronidazole at the same dosage. In two further patients the parasite was not eliminat...

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“…They did not, however, seem to be fully aware of its value, for they modestly claimed that its oral administration was no more than a useful adjuvant to its local application. British workers demonstrated that, given by mouth without any form of local treatment, metronidazole achieved a very high rate of cure, and the results reported by Rodin, King, Nicol, and Barrow (1960) and by Nicol, Barrow, and Redmond (1960) were amply confirmed by other workers. The meeting of the M.S.S.V.D.…”

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confidence: 79%

History of the treatment of trichomoniasis.

Forgan¹

1972

Sexually Transmitted Infections

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Flagyl (8823 R.P.) in the Treatment of Trichomoniasis

Cited by 9 publications

References 1 publication

A review on metronidazole: an old warhorse in antimicrobial chemotherapy

A review on metronidazole: an old warhorse in antimicrobial chemotherapy

Treatment of trichomonal prostatitis with metronidazole.

History of the treatment of trichomoniasis.

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