Flammulina velutipes stem regulates oxidative damage and synthesis of yolk precursors in aging laying hens by regulating the liver–blood–ovary axis

Polysaccharide from Hericium erinaceus improved laying performance of aged hens by promoting yolk precursor synthesis and follicle development via liver-blood-ovary axis

“…Increasing evidence suggests that the decreased functions of the liver and ovaries in aged hens is accompanied by significant decreases in antioxidant level, reproductive hormone secretion, and follicular development, leading to reduced yolk precursor synthesis, thus directly affecting egg production ( Zhang et al, 2019 ). A recent study reported that flammulina stems can improve the antioxidant capacity of aged hens and regulate ovarian apoptosis, hepatic lipid metabolism, and transport, thus improving the egg production of aged hens ( Wu et al, 2023 ). HEP is derived from Hericium erinaceus , a fungus that has the similar medicinal and food homology as flammulina .…”

Effects of Bacillus subtilis Natto NB205 and Its Mutant NBMK308 on Egg Quality in Aging Laying Hens

“…The NBMK308 group alone downregulated the expression of the gene caspase-1, while the protein expression of cleaved caspase-3 showed a decreasing trend in both the NB205 and NBMK308 groups. The downregulation of Bax expression is associated with reduced oxidative damage and improved yolk precursor synthesis in aging laying hens [ 62 ]. FVS supplementation in aging laying hens upregulates the Bcl-2 gene, promoting egg production and ovarian health by improving antioxidant capacity and hormone levels [ 62 ].…”

“…The downregulation of Bax expression is associated with reduced oxidative damage and improved yolk precursor synthesis in aging laying hens [ 62 ]. FVS supplementation in aging laying hens upregulates the Bcl-2 gene, promoting egg production and ovarian health by improving antioxidant capacity and hormone levels [ 62 ]. Downregulation of caspase-1 expression during aging is associated with reduced chronic inflammation and improved insulin sensitivity [ 63 ].…”

Yolk precursor synthesis and deposition in hierarchical follicles and effect on egg production performance of hens

“…Therefore, to expound the factors affecting yolk deposition in the hierarchical follicles among hens with different egg-laying performances, we analyzed the gene expression, transport, and deposition of lipoproteins in the liver, blood, and ovary of high-yield and low-yield hens. Apolipoprotein B, one of the yolk precursors produced in the liver, has been well documented for relating to egg production ( Wu et al, 2022 ). Our results also showed that the expression of the ApoB gene in the liver of JH35 was significantly higher than that of the other 2 groups.…”