In this study, 114 cases of upper urinary calculi were retrospectively analyzed to compare the efficacy of microchannel percutaneous nephrolithotripsy (MPCNL) and flexible ureteroscopic lithotripsy (URHL) for the treatment of renal calculi, and to analyze the efficacy and complications of the two surgical methods, so as to provide a more suitable scheme for the selection of surgical methods for upper urinary calculi. Microchannel percutaneous nephrolithotripsy and flexible ureteroscopic lithotripsy were divided into two groups with 57 cases in each group. There was no significant difference in stone clearance rate between MPCNL group and URHL group. Supine MPCNL group USES the oblique cut stone, relative to the prone position and other positions, patients are more likely to tolerate, 14 f ~ 16 f the microchannel renal tissue injury and reduce bleeding risk reduction, intraoperative for complexity or MPCNL for Angle is too small to deal with a difficult calculi can adopt double mirror combination therapy, made clear the effect of the stone, but because of indwelling renal fistula, postoperative hospital stay longer. The URHL group was more inclined to minimally invasive treatment. It was difficult to lithotripsy for hard stones, and the operation time was relatively long, so the risk of infection was increased. However, patients recovered quickly, the length of hospital stay was short, and the duration of ureteral stent implantation was long. Preoperative surgery should be based on the patient's desire and the actual situation such as stone load to choose a more appropriate way of operation.