Flavan-3-ol-methylxanthine interactions: Modulation of flavan-3-ol bioavailability in volunteers with a functional colon and an ileostomy

Ottaviani, Javier I.; Fong, Reedmond Y.; Borges, Gina; Kimball, Jennifer; Ensunsa, Jodi L.; Medici, Valentina; Pourshahidi, L.K.; Kane, Emma; Ward, Karen; Durkan, Rebecca; Dobani, Sara; Lawther, Roger; O’Connor, Gloria; Gill, Chris; Schroeter, Hagen; Crozier, Alan

doi:10.1016/j.freeradbiomed.2023.01.003

Cited by 5 publications

(1 citation statement)

References 31 publications

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“…On top of that, the interactions between (poly)phenols and other food components further complicate this. For example, recent studies have shown how (poly)phenol oxidase-rich foods such as bananas dramatically influenced the bioavailability of flavan-3-ols when consumed together (24) , or the increase in bioavailability and efficacy of flavan-3-ols when methylxanthines were present (25,26) . Another issue is the lack of specificity of certain (poly)phenol metabolites.…”

Section: Effects Of (Poly)phenols On Cardiometabolic Health: Epidemio...mentioning

confidence: 99%

Dietary (poly)phenols and cardiometabolic health: from antioxidants to modulators of the gut microbiota

Rodriguez-Mateos,

Le Sayec,

Cheok

2024

Proc. Nutr. Soc.

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(Poly)phenols are plant secondary metabolites widely abundant in plant foods and beverages comprising a very large number of compounds with diverse structure and biological activities. Accumulating evidence indicates that these compounds exert beneficial effects against cardiometabolic diseases, and this review will provide a summary of current knowledge in this area. Epidemiological and clinical data collectively suggest that intake of flavonoids reduces the risk of cardiovascular disease (CVD), with the evidence being particularly strong for the flavan-3-ol subclass. However, to provide adequate dietary recommendations, a better understanding of their estimated content in foods and intake among the general public is needed. Regarding mechanisms of action, we now know that it is unlikely that (poly)phenols act as direct antioxidants in vivo, as it was hypothesised for decades with the popularity of in vitro antioxidant capacity assays. One of the reasons is that upon ingestion, (poly)phenols are extensively metabolised into a wide array of circulating metabolites with different bioactivities than their precursors. Well-conducted in vitro and in vivo studies and human nutrigenomic analysis have revealed new molecular targets that may be underlying the health benefits of (poly)phenols, such as the nitric oxide pathway. Recently, a bi-directional relationship was established between (poly)phenols and the gut microbiota, suggesting that individual gut microbial metabolising capacity may be a key factor explaining the variability in the cardiometabolic response to (poly)phenols. Future research is needed to elucidate which are the key factors affecting such capacity, and whether it can be modulated, along with the mechanisms of action.

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Section: Effects Of (Poly)phenols On Cardiometabolic Health: Epidemio...mentioning

confidence: 99%

Dietary (poly)phenols and cardiometabolic health: from antioxidants to modulators of the gut microbiota

Rodriguez-Mateos,

Le Sayec,

Cheok

2024

Proc. Nutr. Soc.

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From controlled transformed cocoa beans to chocolate: Bioactive properties, metabolomic profile, and in vitro bioaccessibility

Becerra,

Quintanilla-Carvajal,

Escobar

et al. 2024

Food Chemistry

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Exploring and disentangling the production of potentially bioactive phenolic catabolites from dietary (poly)phenols, phenylalanine, tyrosine and catecholamines

Clifford,

Ludwig,

Pereira-Caro

et al. 2024

Redox Biology

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Flavan-3-ol-methylxanthine interactions: Modulation of flavan-3-ol bioavailability in volunteers with a functional colon and an ileostomy

Cited by 5 publications

References 31 publications

Dietary (poly)phenols and cardiometabolic health: from antioxidants to modulators of the gut microbiota

Dietary (poly)phenols and cardiometabolic health: from antioxidants to modulators of the gut microbiota

From controlled transformed cocoa beans to chocolate: Bioactive properties, metabolomic profile, and in vitro bioaccessibility

Exploring and disentangling the production of potentially bioactive phenolic catabolites from dietary (poly)phenols, phenylalanine, tyrosine and catecholamines

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