Flavan-3-ols and proanthocyanidins from Limonium brasiliense inhibit the adhesion of Porphyromonas gingivalis to epithelial host cells by interaction with gingipains

Caleare, Ângelo de Oliveira; Hensel, Andreas; Mello, João Carlos Palazzo de; Pinha, Andressa Blainski; Panizzon, Gean Pier; Lechtenberg, Matthias; Petereit, Frank; Nakamura, Celso Vataru

doi:10.1016/j.fitote.2017.03.002

Cited by 28 publications

(35 citation statements)

References 29 publications

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“…BP-4, a soluble UVB filter, can stabilise EGCG to produce effective anti-oxidants. Catechin preparations made with lipid ingredients are less stable in heat, so it is necessary to Gallego et al 2017, Spizzirri et al 2009, Nadim et al 2014, Feng et al 2014, Feng et al 2013, Zhong and Shahidi 2011, Muhammad et al 2014, Li and Seeram 2018, Choi et al 2018, Shoko et al 2018, Lima et al 2016 UV protection Improve the stability of catechins in sunlight and increase the UV protection effect Zhang et al 2016, Yoshino et al 2013, Niu et al 2017, Huang et al 2007, Martincigh and Ollengo 2016, Parisi et al 2012, Kim et al 2012, Xia et al 2005 Anti-microbial activities Demonstrates anti-microbial activity and develops pharmaceuticals and functional cosmetics de Oliveira et al 2017, Aoshima et al 2009, Goyal et al 2017 Anti-allergenic and antiinflammatory activities…”

Section: Discussionmentioning

confidence: 99%

“…Research is underway to produce biological and functional cosmetics using the natural anti-microbial properties of catechins. Human epithelial KB cells cell experiments show thatflavan-3-ols and proanthocyanidin from Limonium brasiliense (L. brasiliense) interact with gingipains to inhibit the adhesion of Porphyromonas gingivalis (P. gingivalis) to epithelial host cells (de Oliveira et al 2017). In studies of the anti-microbial activity of fullerene and its hydroxylated derivatives, C60 (OH)44 was as potent and broadly effective as catechin, which was used as a control for evaluation (Aoshima et al 2009).…”

Section: Anti-microbial Activitymentioning

confidence: 99%

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Activity of catechins and their applications

et al. 2020

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Background: Catechins, which are polyphenol compounds found in many plants and are an important component of tea leaves, are strong anti-oxidants. Research: Many studies seek to enhance the effects of catechins on the human body and boost their protective power against UV radiation. There are many examples of the positive anti-microbial, anti-viral, anti-inflammatory, anti-allergenic, and anti-cancer effects of catechins. Catechins increase the penetration and absorption of healthy functional foods and bio cosmetics into the body and the skin, thus improving their utility. High value-added antioxidant substances have been extracted from food and plant sludge, and experiments have shown that catechins are safe when applied to the human body. The stability of catechins is very important for their absorption into the human body and the effectiveness of their anti-oxidant properties.Conclusion: Continued research on the strong anti-oxidant effects of catechins is expected to result in many advances in the food, cosmetics, and pharmaceutical industries.

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Section: Discussionmentioning

confidence: 99%

Section: Anti-microbial Activitymentioning

confidence: 99%

Activity of catechins and their applications

et al. 2020

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“…On the other hand, the most abundant compounds in L. quesadense extracts were 15 and 16 (gallo(epi)catechin-O-gallate monomer and dimer), followed by myricetin glycosides. Epigallocatechin gallate has been previously reported as the potential mainly responsible for the bioactive properties of L. brasiliense and L. algarvense [11,14].…”

Section: Phytochemical Characterizationmentioning

confidence: 99%

“…Research on species of this genus has revealed important bioactivity concerning the free radical scavenging [7,8], antioxidant [5,[9][10][11], anti-inflammatory [10], antibacterial [12], antimicrobial [9], and antiviral [13] properties. e main phenolics identified as responsible for these activities were gallic acid, epigallocatechin gallate, and myricetin and isorhamnetin flavonoids [7,8,10,11,14].…”

Section: Introductionmentioning

confidence: 99%

Phenolic Profile, Antioxidant Activity, and Enzyme Inhibitory Properties ofLimonium delicatulum(Girard) Kuntze andLimonium quesadenseErben

Ruiz-Riaguas

Zengin

Sinan

et al. 2020

Journal of Chemistry

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In this work, we report the phytochemical composition and bioactive potential of methanolic and aqueous extracts of leaves from Limonium delicatulum (Girard) Kuntze and Limonium quesadense Erben. The characterization and quantitation of individual phytochemicals were performed with liquid chromatography with diode array and electrospray-tandem mass spectrometry detection. Myricetin glycosides were abundant in L. delicatulum, whereas L. quesadense was rich in gallo(epi)catechin-O-gallate. Total phenolics, flavonols, and flavonoids were assayed with conventional methods. Antioxidant and radical scavenging assays (phosphomolybdenum, DPPH, ABTS, CUPRAC, FRAP, and metal chelating activity), as well as enzyme inhibitory assays (acetylcholinesterase, butyrylcholinesterase, tyrosinase, amylase, glucosidase, and lipase), were performed to evaluate the potential bioactivity. The methanolic extracts of both species presented higher phenolic content and bioactivity than the aqueous extracts. Overall, L. quesadense extracts exhibited the most potent activity for most assays, representing a potential source of bioactive compounds for the pharmaceutical and food industries.

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“…Other commonly consumed dietary sources of polyphenols, such as blueberry extract and tea polyphenols (black and green tea extracts and theaflavins) have also been shown to inhibit biofilm formation and slow bacterial growth in several studies [ 26 , 27 , 28 ]. The addition of epigallocatechin-3-gallate (EGCG), which is the most abundant and bioactive green tea polyphenol, and green tea extract to a culture of human gingival epithelial cells inhibited the release of several cytokines [ 29 ].…”

Section: Dietary Polyphenols and Periodontitis: Cellular Studiesmentioning

confidence: 99%

Dietary Polyphenols and Periodontitis—A Mini-Review of Literature

2018

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Periodontitis, which is a chronic infection and disease of the periodontium, is a significant global health burden and is linked to other chronic health conditions such as diabetes and cardiovascular diseases. Dietary polyphenols present in a wide variety of plant-based foods, herbs, and botanicals have been shown to exert antimicrobial, anti-inflammatory, and reduced osteoclast and alveolar bone loss activities in animal models of periodontitis. Polyphenol-containing beverages and foods especially green tea and its active catechin epigallocatechin-3-gallate, cranberries, pomegranates, and fruit and vegetable extracts have reported bacteriostatic/bactericidal activity against microbial species such as P. gingivalis and shown total bacterial burden in clinical studies. These polyphenols also exhibit anti-inflammatory and antioxidant effects, which have the potential to impact various biological mechanisms for reducing the initiation and progression of periodontitis. The main objective of this mini-review is to focus on the mechanisms of action of dietary polyphenols in improving the pathophysiology underlying chronic inflammatory diseases like periodontitis based on pre-clinical and clinical models.

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Flavan-3-ols and proanthocyanidins from Limonium brasiliense inhibit the adhesion of Porphyromonas gingivalis to epithelial host cells by interaction with gingipains

Cited by 28 publications

References 29 publications

Activity of catechins and their applications

Activity of catechins and their applications

Phenolic Profile, Antioxidant Activity, and Enzyme Inhibitory Properties ofLimonium delicatulum(Girard) Kuntze andLimonium quesadenseErben

Dietary Polyphenols and Periodontitis—A Mini-Review of Literature

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