Flavanols are potential anti-obesity agents, a systematic review and meta-analysis of controlled clinical trials

Akhlaghi, Masoumeh; Ghobadi, Saeed; Hosseini, Mehdi; Gholami, Jaleh; Mohammadian, Fatemeh

doi:10.1016/j.numecd.2018.04.001

Cited by 58 publications

(30 citation statements)

References 112 publications

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“…Just consuming 1–2 servings of fruit rich in anthocyanins (such as strawberries, raspberries or blueberries) every day helps significantly reducing the risk of cardiovascular diseases [ 1 ]. In vitro and in vivo studies confirm that flavonoid compounds are desirable from the pharmaceutical point of view activities: they are anti-oxidants, anti-inflammatory, vasorelaxants, anticoagulants, cardioprotective, anti-obesity and anti-diabetic, chemoprotective, neuroprotective, antidepressants, antimicrobials [ 3 , 4 , 5 , 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Glycosylation of Methoxylated Flavonoids in the Cultures of Isaria fumosorosea KCH J2

2018

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Flavonoids are widely described plant secondary metabolites with high and diverse pro-health properties. In nature, they occur mostly in the form of glycosides. Our research showed that an excellent way to obtain the sugar derivatives of flavonoids is through biotransformations with the use of entomopathogenic filamentous fungi as biocatalysts. In the current paper, we described the biotransformations of five methoxylated flavonoid compounds (2′-methoxyflavanone, 3′-methoxyflavanone, 4′-methoxyflavanone, 6-methoxyflavanone, and 6-methoxyflavone) in cultures of Isaria fumosorosea KCH J2. As a result, we obtained twelve new flavonoid 4-O-methylglucopyranosides. The products were purified with methods that enabled the reduction of the consumption of organic solvents (preparative TLC and flash chromatography). The structures of the products were confirmed with spectroscopic methods (NMR: 1H, 13C, HSQC, HMBC, COSY). The compounds obtained by us expand the library of available flavonoid derivatives and can be used in biological research.

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Section: Introductionmentioning

confidence: 99%

Glycosylation of Methoxylated Flavonoids in the Cultures of Isaria fumosorosea KCH J2

2018

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“…The anti-obesity potential of flavonols has been also explored. A meta-analysis based on 58 controlled clinical trials demonstrated that flavanols intake decreased body mass index and waist circumference (Akhlaghi, Ghobadi, Mohammad Hosseini, Gholami, & Mohammadian, 2018). Finally, a systematic review based on 13 clinical trials concluded that "cocoa flavonols intake may improve vascular function, reduce exercise-induced oxidative stress, and alter fat and carbohydrate utilization during exercise, but without affecting exercise performance" (Decroix, Soares, Meeusen, Heyman, & Tonoli, 2018).…”

Section: Flavanolsmentioning

confidence: 99%

Polyphenols: A concise overview on the chemistry, occurrence, and human health

Durazzo

Lucarini

Souto

et al. 2019

Phytotherapy Research

611

397

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This review gives an updated picture of each class of phenolic compounds and their properties. The most common classification implies the subdivision of phenolics in two main groups: flavonoids (e.g., anthocyanins, flavanols, flavanones, flavonols, flavonones, and isoflavones) and non‐flavonoids (e.g., phenolic acids, xanthones, stilbens, lignans, and tannins) polyphenols. The great interest in polyphenols is associated with their high potential application for food preservation and for therapeutic beneficial use. The relationship between polyphenol intake and human health has been exploited with special reference to cardiovascular diseases, hypertension, diabetes, metabolic syndrome, obesity, and cancer. The use of current existing databases of bioactive compounds including polyphenols is described as key tools for human health research.

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“…) as well as protect against obesity (Akhlaghi et al . ). Flavanols influence also positively insulin signalling by relieving insulin‐signalling pathways from oxidative stress (OS) and inflammation and/or via a heightened incretin response (Strat et al .…”

Section: Introductionmentioning

confidence: 97%

“…However, in the body they exert a plethora of other effects which can be only partly or not at all related to their antioxidant action. They have been reported to lower blood pressure, especially in prehypertensive and hypertensive individuals, modulate metabolism and respiration including maximal oxygen uptake, O 2 cost of exercise and energy expenditure, and reduce inflammation, resulting in increased skeletal muscle efficiency and endurance capacity (Al-Dashti et al 2018), positively modulate blood platelet aggregation (Peluso et al 2015), improve endothelial function (Aprotosoaie et al 2016) as well as protect against obesity (Akhlaghi et al 2018). Flavanols influence also positively insulin signalling by relieving insulin-signalling pathways from oxidative stress (OS) and inflammation and/or via a heightened incretin response (Strat et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Flavanols protect the yeastSaccharomyces cerevisiaeagainst heating and freezing/thawing injury

Naparło

Żyracka

Bartosz

et al. 2019

Journal of Applied Microbiology

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Aims The aim of the study was to check whether two flavanols ((−)‐epigallocatechin gallate and (+)‐catechin) can ameliorate oxidative stress (OS) accompanying and contributing to the lethal effects of heating (50°C) and freezing‐thawing on the yeast Saccharomyces cerevisiae. Methods and Results The flavanols studied increased yeast survival during heating and freezing‐thawing, estimated by the colony forming assay. They improved also such indices of OS as increased production of reactive oxygen species, decrease of total antioxidant activity of yeast cell extracts and increase in the level of protein carbonyls. Conclusions Amelioration of OS by flavanols increases the survival of the yeast subjected to high temperature and freezing‐thawing. Significance and Impact of the Study Flavanols may be considered as means of enhancing yeast survival under extreme temperature conditions and probably in other conditions involving OS.

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Flavanols are potential anti-obesity agents, a systematic review and meta-analysis of controlled clinical trials

Cited by 58 publications

References 112 publications

Glycosylation of Methoxylated Flavonoids in the Cultures of Isaria fumosorosea KCH J2

Glycosylation of Methoxylated Flavonoids in the Cultures of Isaria fumosorosea KCH J2

Polyphenols: A concise overview on the chemistry, occurrence, and human health

Flavanols protect the yeastSaccharomyces cerevisiaeagainst heating and freezing/thawing injury

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