Flaviviruses as agents of childhood central nervous system infections in Brazil

Marinho, P.E. Silva; Kroon, Erna Geessien

doi:10.1016/j.nmni.2019.100539

Cited by 7 publications

(2 citation statements)

References 40 publications

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“…Notably, DENV was associated with cases of meningitis and encephalitis in pediatric patients. Our findings are consistent with those of Marinho et al (46), who also reported a low prevalence of dengue in CNS samples from the pediatric population. In arbovirus-endemic regions like the Amazon, it is important laboratory surveillance for monitoring the diagnosis of encephalitogenic viruses.…”

Section: Discussionsupporting

confidence: 93%

Pediatric central nervous system infections in the Amazon: clinical and laboratory profiles

Marinho,

Ferreira,

Barrionuevo

et al. 2023

Front. Public Health

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BackgroundCentral nervous system (CNS) infections are important causes of mortality and morbidity in children, and they are related to severe problems such as hearing loss, neurological sequelae, and death. The objective was to describe clinical and laboratory exam profiles of children who were diagnosed with CNS infections.MethodsWe conducted a cross-sectional study based on medical records, which included pediatric patients aged from 3 months to 15 years, with a clinical suspicion of CNS infection between January 2014 to December 2019. The pathogens were confirmed in cerebrospinal fluid (CSF) samples using Gram staining, cell culture, molecular diagnostics (PCR and qPCR), and serology.ResultsOut of the 689 enrolled patients, 108 (15.6%) had laboratory-confirmed infections in CSF. The most common bacterial pathogens isolated from the culture were Neisseria meningitidis serogroup C in 19, Streptococcus pneumoniae in 11, and Haemophilus influenzae in seven samples. The viruses identified were Enterovirus, Cytomegalovirus, Varicella-zoster virus, Epstein–Barr virus, and arbovirus. No patient was found to be positive for Herpes simplex virus 1 and 2. Patients with viral infections showed altered levels of consciousness (p = 0.001) when compared to bacterial infections.ConclusionThis study shows the presence of important vaccine-preventable pathogens, and different families of viruses causing CNS infections in the pediatric patients of Manaus.

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Section: Discussionsupporting

confidence: 93%

Pediatric central nervous system infections in the Amazon: clinical and laboratory profiles

Marinho,

Ferreira,

Barrionuevo

et al. 2023

Front. Public Health

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“…Neuroimaging is another essential tool for confirming a diagnosis and for determining the extent of brain damage. Both computed tomography (CT) scan and magnetic resonance imaging (MRI) are used, but MRI tends to be more diagnostic [ 16 , 19 ]. RT-PCR can be done on CSF, blood, urine or breast milk [ 3 , 20 ].…”

Section: Reviewmentioning

confidence: 99%

Viral Infections of the Central Nervous System in Children: A Systematic Review

Abdullahi¹,

Sarmast²,

Jahan³

2020

Cureus

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Viral infections of the central nervous system such as meningitis, encephalitis or meningoencephalitis, are important causes of significant morbidities and mortality worldwide. Early diagnosis and prompt treatment will lead to better outcomes, but any delay may results in high fatality with serious neurologic sequelae among survivors. We conducted a systematic review of published literature on the clinical presentation, diagnosis, treatment and complications of viral infections of the central nervous system from 1980 to 2019 on four databases comprising of PubMed, PubMed Central, Google Scholar and Medline to give the current understanding for better patient management. This systematic review demonstrates the management approach of viral infections of the central nervous system in children from the point of clinical presentation, diagnosis, treatment and complications. Definitive treatment remained unknown; however, certain antiviral drugs were proved to be effective. Therefore, prevention through childhood vaccination is the best management option.

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