Flavonoid Glycosides from Anisomeles ovata

The constituents of Anisomeles indica and their anti-inflammatory activities

“…This is the first report on these compounds for their growth inhibitory effects against NO, TNF-␣ and IL-12 production in LPS/IFN-␥-stimulated macrophages. Furthermore, in the reported anti-inflammatory activity of crude extracts (Dharmasiri et al, 2002(Dharmasiri et al, , 2003, these compounds might also act additionally or synergistically with the reported constituents (Arisawa et al, 1986a;Rao et al, 1985). Further studies to clarify the molecular mechanisms of the active components reported here are currently under investigation and the findings will be the subject of a future publication.…”

“…We have recently reported that the methanol extract of Anisomeles indica could inhibit the enhanced production of inflammatory mediators, and tumor cell proliferation (Hsieh et al, 2008). Previous investigations on the chemical composition of this herb resulted in the isolation of various constituents, including terpenoids, flavonoids, steroids and certain miscellaneous substances (Manchand and Blount, 1977;Ansari and Dobhal, 1982;Arisawa et al, 1986a,b;Rao et al, 1983aRao et al, ,b,c, 1984Rao et al, , 1985Dobhal et al, 1988;Shahidul Alama et al, 2000), it still lacks the evidence to elucidate the active anti-inflammatory components in Anisomeles indica. Therefore, the purpose of the present study was to isolate and identify the potent anti-inflammatory components of Anisomeles indica, and investigate their preliminary anti-inflammatory mechanism.…”

5,6,3′,4′-Tetrahydroxy-7-methoxyflavone as a Novel Potential Proteasome Inhibitor

“…2-1 and fr. 2-3 was subjected to Sephadex LH-20 (33.0 × 10.0 cm, 300 g) column by eluting with MeOH (6 L) and subsequent preparative HPLC purification (C-18 column, 25.0 × 2.5 cm, particle size 15 µm; mobile phase: MeOH-H 2 O, 35 : 65; flow rate 15 mL/ min; detection: 254 nm) to yield vanillic acid (3, 9.7 mg) [25] and p-hydroxyacetophenone (4, 6.0 mg) [24]. The fr.…”

“…(Labiatae) constitute a traditional Chinese herb used for rheumatism, bone pains, cold fever, abdominal cramps, skin sores, antidote, arisawa stomach ache, boil, piles, and arthritis [15]. Previous reports showed that the chemical composition of the aerial parts of Anisomeles ovata included macrocyclic diterpenoids, flavonoids, steroids, and certain miscellaneous substances [16][17][18][19][20][21][22][23][24]. However, there is no study of the effects of Anisomeles ovata R. Br.…”

Toxicity Evaluation of Anisomeles indica Kuntze Leaf Flavonoid Fraction

“…A. indica has significant gastro-protective activity that is mediated via an increase in the thickness of the protective mucous layer and by antioxidant activity [9][10][11]. Published reports in pertinent literature suggest that, A. indica contains secondary metabolites including flavonoids, diterpenoids, phenyl propanoids, steroids and yields essential oil [9][10][12][13][14][15][16][17][18][19]. Ethanol extract of A. indica is active against Helicobacter pylori infection [10].…”