The constituents of Anisomeles indica and their anti-inflammatory activities

Rao, Yerra Koteswara; Fang, Shih-Hua; Hsieh, Shih-Chuan; Yeh, Tsung-Hsien; Tzeng, Yew‐Min

doi:10.1016/j.jep.2008.10.032

Cited by 86 publications

(49 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The extract of Anisomeles ovata has long been used for the treatment of diverse inflammatory relative skin and liver diseases in Taiwan [9], however, the active ingredients and the molecular mechanisms of the anti-inflammatory activity remained elusive. In the present study, one of the major components of methanol-extracted Anisomeles ovata, 5-TDMF, was isolated and its pharmacological activity evaluated for free radical-scavenging and anti-inflammatory potential.…”

Section: Discussionmentioning

confidence: 99%

“…Anisomeles ovata R. Br, also known as Anisomeles indica Kuntz., is the only species of the Labiatae family found in Taiwan and has been widely used as a herbal remedy to treat inflammation-related liver and skin diseases, hypertension and immune deficiencies [6]. Recent studies have suggested that Anisomeles ovata extracts exert various biological activities, including anti-oxidant, anti-inflammatory and tumor cell proliferation inhibitory [7][8][9][10], however, the underlying pharmacological mechanisms are still unclear. In order to identify the active ingredients of Anisomeles ovata, a number of chemical components have been identified, including flavonoids, terpenoids and steroids [9,[11][12][13].…”

Section: Introductionmentioning

confidence: 99%

“…Recent studies have suggested that Anisomeles ovata extracts exert various biological activities, including anti-oxidant, anti-inflammatory and tumor cell proliferation inhibitory [7][8][9][10], however, the underlying pharmacological mechanisms are still unclear. In order to identify the active ingredients of Anisomeles ovata, a number of chemical components have been identified, including flavonoids, terpenoids and steroids [9,[11][12][13]. Among the isolated compounds, 5,6,4 1 -trihydroxy-7,3 1 -dimethoxyflavone (5-TDMF) was found to be the major flavonoid in the methanol extract of Anisomeles ovata [14].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Inhibitory Mechanisms Study of 5,6,4′-Trihydroxy-7,3′-Dimethoxyflavone against the LPS-Induced Macrophage Inflammatory Responses through the Antioxidant Ability

Wang

Liang

et al. 2016

Molecules

View full text Add to dashboard Cite

Abstract:The whole plant of Anisomeles ovata has been widely used in Taiwan for treating inflammation-related skin and liver diseases, however, the detailed pharmacology mechanisms have yet to be elucidated. In the present study, one of the major components, 5,6,4 1 -trihydroxy-7,3 1 -dimethoxyflavone (5-TDMF), was purified from a methanol extract of Anisomeles ovata. A pharmacological study of this compound suggests that 5-TDMF possesses potent free radical scavenging activity both in vitro and ex vivo. Furthermore, 5-TDMF reduces nitric oxide and pro-inflammatory cytokine production in LPC-treated RAW 264.7 cells through the attenuation of nitric oxide synthase and cyclooxygenase-2. Additional experiments suggest that of 5-TDMF interferes with nuclear factor-κB translocation and mitogen-activated protein kinase pathways. These results identify 5-TDMF as an anti-oxidant and anti-inflammatory compound, explain the pharmacologic function of Anisomeles ovata and suggest its great potential as a new anti-inflammatory remedy.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Inhibitory Mechanisms Study of 5,6,4′-Trihydroxy-7,3′-Dimethoxyflavone against the LPS-Induced Macrophage Inflammatory Responses through the Antioxidant Ability

Wang

Liang

et al. 2016

Molecules

View full text Add to dashboard Cite

show abstract

“…The plant is used for the treatment of inflammatory skin diseases, liver disease and protection, gastrointestinal disease, hypertension and immune system deficiencies [34][35]. Extracts and isolated constituents of A. indica has been demonstrated to possess, anti-inflammatory, anti-tumor cell proliferation, bactericidal function against H. pylori [21,22,36]. Despite the medicinal and pharmacological properties of A. indica extracts and isolated constituents, there are no data available in the pertinent literature on the toxicological concerns of this plant, its extracts and isolated constituents that would be useful for the safety assessment and dosage fixation.…”

Section: Discussionmentioning

confidence: 99%

“…Ethanol extract of A. indica is active against Helicobacter pylori infection [10]. Ovatodiolide, a diterpenoid of A. indica has been shown to anti-HIV activity (IC 50 of 1.2 µg/mL) with maximum cellular protection upto 80-90%, tumor cell proliferation and inflammatory mediators [20][21][22]. Ovatodiolide pre-treatment to Triple-Negative Breast Cancer (TNBC) cells sensitizes the cells for doxorubicin cytotoxicity, and make the cells to lose their cancer stem cell-like phenotype [23].…”

Section: Introductionmentioning

confidence: 99%

Toxicity Evaluation of Anisomeles indica Kuntze Leaf Flavonoid Fraction

Basappa¹,

Kumar²

2016

J Pharmacogn Nat Prod

View full text Add to dashboard Cite

Verbascoside administered intrathecally attenuates hyperalgesia via activating mu‐opioid receptors in a rat chronic constriction injury model

Hara

Haranishi

Terada

2022

European Journal of Pain

View full text Add to dashboard Cite

Background: Verbascoside, a representative phenylethanoid glycoside, is widely distributed in plants and has various activities beneficial for human health.Although systemically administered verbascoside has an antinociceptive effect, little is known about the site and mechanism of its activity. The aim of the present study was to determine whether verbascoside attenuates neuropathic pain in the spinal cord and which pain regulatory systems are involved.Methods: Chronic constriction injury of the sciatic nerve was introduced to male Sprague Dawley rats. The effects of intrathecal administration of verbascoside and its components (caffeic acid and hydroxytyrosol) on mechanical hyperalgesia and cold hyperalgesia were examined using the electronic von Frey test and cold-plate test, respectively. Several antagonists of spinal pain processing receptors were administered intrathecally to evaluate their effects on the antihyperalgesic action of verbascoside. A rotarod test was performed to assess the effects on motor coordination.Results: Verbascoside attenuated mechanical and cold hyperalgesia and affected motor performance in a dose-dependent manner. Caffeic acid suppressed hyperalgesia only at high doses, whereas hydroxytyrosol did not affect hyperalgesia. The inhibitory effects of verbascoside on hyperalgesia and motor coordination were reversed by naloxone, a µ-opioid receptor antagonist.Conclusions: These findings imply that verbascoside exerts an antihyperalgesic effect by activating µ-opioid receptors in the spinal cord, and that neither caffeic acid nor hydroxytyrosol alone mediates its activity. Verbascoside shows promise for the treatment of neuropathic pain.Significance: Currently available treatments for neuropathic pain have limited efficacy in most patients. Some natural products have favourable biological activities for long-term administration such as antioxidative and neuroprotective effects. Verbascoside inhibits spinal nociceptive transmission without serious side effects to the same degree as gabapentin, a first-line remedy for neuropathic pain.Natural products may be promising candidates for novel treatments of neuropathic pain.

show abstract

The constituents of Anisomeles indica and their anti-inflammatory activities

Cited by 86 publications

References 25 publications

The Inhibitory Mechanisms Study of 5,6,4′-Trihydroxy-7,3′-Dimethoxyflavone against the LPS-Induced Macrophage Inflammatory Responses through the Antioxidant Ability

The Inhibitory Mechanisms Study of 5,6,4′-Trihydroxy-7,3′-Dimethoxyflavone against the LPS-Induced Macrophage Inflammatory Responses through the Antioxidant Ability

Toxicity Evaluation of Anisomeles indica Kuntze Leaf Flavonoid Fraction

Verbascoside administered intrathecally attenuates hyperalgesia via activating mu‐opioid receptors in a rat chronic constriction injury model

Contact Info

Product

Resources

About