Flavonoid mixture (diosmin, troxerutin, rutin, hesperidin, quercetin) in the treatment of I–III degree hemorroidal disease: a double-blind multicenter prospective comparative study

Corsale, I; Carrieri, Paolo; Martellucci, Jacopo; Piccolomini, Alessandro; Verre, Luigi; Rigutini, M.; Panicucci, Sonia

doi:10.1007/s00384-018-3102-y

Cited by 44 publications

(22 citation statements)

References 27 publications

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“…Outcomes, such as bleeding and overall symptom improvement, show a statistically significant beneficial effect, and there were few concerns regarding their overall safety from the evidence presented in the clinical trials 26. In particular, diosmin shows anti-inflammatory and antioxidant activities, phlebotonic and vasoactive effects, improving venous tone, lymphatic drainage, and capillary hyperpermeability 27. A new micronized diosmin formulation has been recently developed to increase bioavailability for the treatment of hemorrhoids 28.…”

Section: Management Of Hemorrhoids In Women: State Of the Artmentioning

confidence: 99%

Hemorrhoid management in women: the role of tribenoside + lidocaine

Kestřánek

2019

DIC

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Hemorrhoids are commonly reported in women. However, despite the high prevalence of hemorrhoids in women and the major impact of this condition on quality of life, specific evidence and recommendations on the treatment of hemorrhoids in women are scant. This paper reviews various options in current therapy for hemorrhoids in women—namely, medical intervention (topical and systemic drug therapy)—and discusses the available clinical evidence for an appropriate use of over-the-counter topical formulations for the symptomatic treatment of hemorrhoids. Its focus is on a medical preparation containing tribenoside + lidocaine, available as a rectal cream (tribenoside 5%/lidocaine 2%) and a suppository (tribenoside 400 mg/lidocaine 40 mg) and marketed under the brand Procto-Glyvenol® (Recordati, SpA, Italy). Given its rapid comprehensive efficacy on all the different symptoms of hemorrhoids, the tribenoside + lidocaine combination can find a place in the treatment of this hemorrhoidal disease. Importantly, its efficacy and tolerability have been formally evaluated in several well-conducted studies, some of which were specifically conducted in women. In particular, tribenoside + lidocaine can be safely administered in postpartum women and in pregnant women after the first trimester of pregnancy. In pregnant women, the tribenoside/lidocaine combination significantly improved both subjective and objective symptoms of hemorrhoids. Fast onset of symptom relief was reported from 10 minutes after administration, lasting up to 10–12 hours. On these bases, tribenoside + lidocaine can represent a fast, effective, and safe option to treat hemorrhoids when conservative therapy is indicated, and it deserves consideration as a first-line treatment of this disease in clinical practice.

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Section: Management Of Hemorrhoids In Women: State Of the Artmentioning

confidence: 99%

Hemorrhoid management in women: the role of tribenoside + lidocaine

Kestřánek

2019

DIC

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“…The efficacy of phlebotonic therapy in HD treatment, widely studied and used in chronic vascular insufficiency, remains, among scientists and physicians, debatable [9,22]. This approach is usually indicated for low-grade HD [23,24]. Although the mechanism of action is not completely understood, several studies have demonstrated the efficacy of flavonoids in patients affected by HD.…”

Section: Discussionmentioning

confidence: 99%

A Prospective Study on the Efficacy of Two Different Phlebotonic Therapies as a Bridge to Surgery in Patients with Advanced Hemorrhoidal Disease

Orefice

Litta

Parello

et al. 2021

JCM

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The aims of this study were to evaluate the efficacy of two different phlebotonic therapies, preoperatively administered in advanced hemorrhoidal disease (HD) patients with recommendation for surgery, and to assess patient satisfaction after treatment. In this prospective observational study, 100 patients were preoperatively treated either with micronized purified flavonoid fraction (group A) or sublingual nano-emulsion flavonoid (group B). HD symptoms, local inflammation signs and patients’ satisfaction were evaluated at baseline visit (T0), after 4 weeks of therapy (T1) and 8 weeks after its discontinuation (T2). In group A, a significant improvement for all HD symptoms and inflammation signs was observed after therapy (T1), followed by a reduction of efficacy in T2, except for itching and edema. In group B, therapy had a significant benefit on symptoms and local inflammation at T1, which persisted after its discontinuation for all symptoms, and edematous hemorrhoids. In both groups, the satisfaction rate was “good” in 60% of patients and patients were statistically significant more satisfied at T1 compared with T2 (p = 0.0001). No adverse events were recorded. Preoperative treatment was safe and useful to optimize patients’ clinical condition prior to surgery.

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“…Flavonoids, a class of secondary plant metabolites, have been shown to demonstrate a wide spectrum of biological activity, among others antioxidant (Santos et al, 1999), anti-inflammatory (Pintho et al, 2016), anti-allergic (Kawai et al, 2006), antiatherosclerotic (Goldwasser et al, 2011), antidiabetic (Rayidi et al, 2011) as well as hepatoprotective (Renugadevi et al, 2009). Corsale et al (2018) used a mixture of flavonoids such as diosmin, troxerutin, rutin, hesperidin, and quercetin to reduce bleeding due to hemorrhoidal disease. Cicero et al (2019) evaluated the effectiveness of bergamot flavonoid extract in people with dyslipidemia and those overweight.…”

Section: Introductionmentioning

confidence: 99%

Selected flavonoids and their role in the treatment of epilepsy – a review of the latest reports from experimental studies

Szala-Rycaj

Zagaja

Szewczyk

et al. 2021

Acta Neurobiologiae Experimentalis

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Epilepsy is a chronic neurological disease characterized by recurrent seizures that affects about 70 million people worldwide.Antiepileptic drugs are the most commonly used medications in the treatment of epilepsy. They help control seizures in about 60-70% of people. The remaining percentage of patients suffer from drug-resistant epilepsy, prompting scientists to look for natural substances that would prevent seizures or support the effects of drugs in add-on therapy while reducing side effects. Currently, there is a lot of emphasis on natural product. Flavonoids are included in this group, and their use in the treatment of epilepsy could support the effect of other drugs. Due to very good results of preclinical studies, flavonoids are a promising candidate for epilepsy related clinical trials related. The article is an overview of literature reports from the past 10 years including mainly in vivo preclinical research on various models of experimental epilepsy with the use of selected flavonoids.

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Flavonoid mixture (diosmin, troxerutin, rutin, hesperidin, quercetin) in the treatment of I–III degree hemorroidal disease: a double-blind multicenter prospective comparative study

Abstract: Use of flavonoids mixture (diosmin, troxerutin, rutin, hesperidin, quercetin) is a safe and effective mean of managing bleeding from hemorrhoidal disease and minimal adverse events are reported.

Cited by 44 publications

References 27 publications

Hemorrhoid management in women: the role of tribenoside + lidocaine

Hemorrhoid management in women: the role of tribenoside + lidocaine

A Prospective Study on the Efficacy of Two Different Phlebotonic Therapies as a Bridge to Surgery in Patients with Advanced Hemorrhoidal Disease

Selected flavonoids and their role in the treatment of epilepsy – a review of the latest reports from experimental studies

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