Flavonoids and an alkaloid from Zanthoxylum naranjillo and their in vitro evaluation on the reproductive fitness of Schistosoma mansoni

Origanum majorana belongs to the Lamiaceae family as a famous spice plant in Egypt, which is used to treat arthritis, allergies, fever, flu, hypertension, respiratory infections, migraine, and asthma. In our studies, it was found that the ethanol extract of O. marjoram could significantly reduce NO release at 200 ( P < 0.001 ), 100 ( P < 0.001 ) and 50 ( P < 0.01 ) μg/mL compared with the model group. Therefore, the chemical constituents were further studied to obtain the bioactive compounds. As a result, ten compounds were isolated and identified from the 70% ethanol extract of O. marjoram, including six flavonoids (3–8), two terpene derivatives (9-10), one lignan (2), and one phenolic glycoside (1). Among them, compounds 1–3, 5, and 9-10 were isolated from this genus for the first time. Compounds 1, 9, and 10 could significantly decrease the content of NO at the concentration of 100 μm ( P < 0.001 ) in RAW264.7 cells induced by LPS. Furthermore, compounds 9 and 10 were more effective than compound 1 to lower the content at 50 μm ( P < 0.001 ).

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Genus Zanthoxylum as Sources of Drugs for Treatment of Tropical Parasitic Diseases

Patil

Mallya

2022

CDDT

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The tropical parasitic infections account to more than 2 billion infections and cause substantial morbidity and mortality, and accounts to several million deaths every year. Majorly parasitic infections in humans and animals are caused by protozoa and helminths. Chronic infections in host can cause retardation, impairment of cognitive skills, development in young children and weaken the immune system. The burden is felt to a greater extent in developing countries due to poverty, inaccessibility to medicines and resistance observed to drugs. Thus, human health continues to be severely harmed by parasitic infections. Medicinal plants have received much attention as alternative sources of drugs. Zanthoxylum genus has been used ethnobotanically as an antiparasitic agent and the phytoconstituents in Zanthoxylum, show wide variety of chemical substances with proven pharmacological actions such as alkaloids (isoquinolines and quinolines responsible for antitumor activity, antimalarial, antioxidant and antimicrobial actions), lignans, coumarins (antibacterial, antitumour, vasodilatory and anticoagulant activities), alkamide (strong insecticidal properties, anthelminthic, antitussive and analgesic anti antimalarial property). Therefore, this article is an attempt to review the existing literature that emphasizes on potential of genus Zanthoxylum as source of lead compounds for treatment of parasitic diseases.

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Flavonoids and an alkaloid from Zanthoxylum naranjillo and their in vitro evaluation on the reproductive fitness of Schistosoma mansoni

Cited by 4 publications

References 16 publications

RP-HPLC method for estimation of sesamin in two Zanthoxylum species

RP-HPLC method for estimation of sesamin in two Zanthoxylum species

Anti-Inflammatory Phytoconstituents of Origanum Majorana

Genus Zanthoxylum as Sources of Drugs for Treatment of Tropical Parasitic Diseases

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