Flavonoids and bladder cancer risk

Rossi, Marta; Strikoudi, Panagiota; Spei, Maria-Eleni; Parpinel, Maria; Serraino, Diego; Montella, Maurizio; Libra, Massimo; Vecchia, Carlo La; Rosato, Valentina

doi:10.1007/s10552-019-01158-2

Cited by 21 publications

(11 citation statements)

References 48 publications

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“…High isoflavones intake has been associated with a 60% reduction of breast cancer risk in Chinese women, particularly those with high waist-hip ratios and body mass indexes greater than 25 kg/m 2 [101]. Isoflavone intake in recent meta-analyses and case-control studies have shown to have a protective effect against lung, breast, ovarian, and bladder cancers [8,102,103]. However, no association between breast cancer and total intake of isoflavones was found in studies of Europeans cohorts [104].…”

Section: Dietary Intake Of Flavonoids and Their Epidemiological Rementioning

confidence: 99%

“…This increased intake of flavone in Italian women was associated with a decrease risk in breast cancer, specifically in pre/peri-menopausal women [107]. An Italian case-control study reported that flavones show a protective effect on bladder cancer [103]. Moreover, a meta-analysis combining 12 independent studies reported a significant association of flavonol and flavone intake with a reduced risk of breast cancer was found specially for post-menopausal women, however no significant associations was found with intake of flavan-3-ols, flavanones, anthocyanins or total flavonoids [108].…”

Section: Dietary Intake Of Flavonoids and Their Epidemiological Rementioning

confidence: 99%

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Dietary Flavonoids for Immunoregulation and Cancer: Food Design for Targeting Disease

2019

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Flavonoids, one of the most abundant phytochemicals in a diet rich in fruits and vegetables, have been recognized as possessing anti-proliferative, antioxidant, anti-inflammatory, and estrogenic activities. Numerous cellular and animal-based studies show that flavonoids can function as antioxidants by preventing DNA damage and scavenging reactive oxygen radicals, inhibiting formation of DNA adducts, enhancing DNA repair, interfering with chemical damage by induction of Phase II enzymes, and modifying signaling pathways. Recent evidence also shows their ability to regulate the immune system. However, findings from clinical trials have been mixed with no clear consensus on dose, frequency, or type of flavonoids best suited to elicit many of the beneficial effects. Delivery of these bioactive compounds to their biological targets through “targeted designed” food processing strategies is critical to reach effective concentration in vivo. Thus, the identification of novel approaches that optimize flavonoid bioavailability is essential for their successful clinical application. In this review, we discuss the relevance of increasing flavonoid bioavailability, by agricultural engineering and “targeted food design” in the context of the immune system and cancer.

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Section: Dietary Intake Of Flavonoids and Their Epidemiological Rementioning

confidence: 99%

Section: Dietary Intake Of Flavonoids and Their Epidemiological Rementioning

confidence: 99%

Dietary Flavonoids for Immunoregulation and Cancer: Food Design for Targeting Disease

2019

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“…Flavonoids are a group of naturally occurring polyphenol compounds found in fruits, vegetables and beverages derived from plants. Due to flavonoids have selective cytotoxicity to cancer cells and low toxicity to normal cells, there is considerable interest in developing it as potential cancer therapeutics 6) . Ampelopsin, also known as dihydromyricetin (DHM), is a flavonoid with high content in the medicinal and edible plant rattan tea (also known as mildew tea).…”

Section: Introductionmentioning

confidence: 99%

Ampelopsin Inhibits Breast Cancer Cell Growth through Mitochondrial Apoptosis Pathway

Zhou²,

Wang

et al. 2021

Biological & Pharmaceutical Bulletin

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Ampelopsin, a flavonoid with a wide variety of biological activities, has been proposed to be a potent antitumor agent. However, the mechanism by which Ampelopsin shows anti-breast cancer activity remains unclear. Therefore, this study will explore the mechanism of Ampelopsin's anti-breast cancer activity by culturing MDA-MB-231 and MCF-7 breast cancer cells. CCK-8 method and plate cloning method were used to detect the proliferation inhibition of breast cancer cells.Fluorescence microscopy was used to detect mitochondrial membrane potential (MMP). DCFH-DA method was used to determine the content of intracellular reactive oxygen species (ROS). Hoechst 33258 staining was used to detect the apoptotic morphological changes. Transmission electron microscope was used to observe the mitochondrial structure. Western Blot was used to detect the protein expression of Bax and Bcl-2. The results showed that Ampelopsin could significantly inhibit the proliferation of breast cancer cells, and promote cells apoptosis. In addition, the occurrence of apoptosis in breast cancer cells was associated with mitochondrial dysfunction, including the loss of mitochondrial membrane potential, the production of large amounts of reactive oxygen species, and the up-regulation of Bax/Bcl-2 expression. In conclusion, Ampelopsin-induced mitochondria damage leads to loss of mitochondria membrane potential, overproduction of ROS and activation of Bax, increasing mitochondria membrane permeability and ultimately inducing breast cell apoptosis. These findings provided a new perspective on the role of Ampelopsin in breast cancer prevention and treatment.

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“…To date, more than 650 ANTs have been identified from fruits and vegetables [7]. ANT micronutrients have many beneficial health effects, including cancer-preventive, immuno-protective, and neuroprotective effects; moreover, they prevent cognitive function impairment, alleviate inflamed and arduous joints, and attenuate rotundity, alopecia, dementia, cardiovascular diseases, and obesity [8,9,10,11,12,13]. Blackberries ( Rubus sp .…”

Section: Introductionmentioning

confidence: 99%

Anthocyanins Potentially Contribute to Defense against Alzheimer’s Disease

2019

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Anthocyanins (ANTs) are plant pigments that belong to a flavanol class of polyphenols and have diverse pharmacological properties. These compounds are primarily found in fruits and vegetables, with an average daily intake of 180 mgd−1 of these compounds in the developed world. ANTs are potent antioxidants that might regulate the free radical-mediated generation of amyloid peptides (Abeta-amyloids) in the brain, which causes Alzheimer’s disease (AD). This study presents a literature review of ANTs from different berries and their potential therapeutic value, with particular emphasis on neurodegenerative AD, which owing to oxidative stress. This review also highlights reactive oxygen species (ROS) generation through energy metabolism, nitrogen reactive species, the role of transition metals in generating ROS, and the radical-quenching mechanisms of natural antioxidants, including ANTs. The current status of the bioavailability, solubility, and structure activity relationship of ANTs is discussed herein.

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Flavonoids and bladder cancer risk

Cited by 21 publications

References 48 publications

Dietary Flavonoids for Immunoregulation and Cancer: Food Design for Targeting Disease

Dietary Flavonoids for Immunoregulation and Cancer: Food Design for Targeting Disease

Ampelopsin Inhibits Breast Cancer Cell Growth through Mitochondrial Apoptosis Pathway

Anthocyanins Potentially Contribute to Defense against Alzheimer’s Disease

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