Flavonoids as antioxidant agents: Importance of their interaction with biomembranes

Saija, Antonella; Scalese, M.; Lanza, Marcos R. V.; Marzullo, Daniela; Bonina, Francesco; Castelli, Francesco

doi:10.1016/0891-5849(94)00240-k

Cited by 627 publications

(342 citation statements)

References 29 publications

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“…The capability to interact with protein phosphorylation and the antioxidant iron chelating and free radicals scavenging activity. 29,30 A number of flavonoids are known to possess good anti-inflammatory antibacterial, antiheptootxic activity. 31 Flavonoids has reported that protective against environmental toxic agents and phytochemical analysis revealed that various chemical constituents like; monoterpenes (from essential oil), flavonoids, biflavonoid glycosides, phytosterols, amino acids, saponins, tannins, alkaloids, lipids, triterpenoids, steroids, diterpene glycosides and alkaloids are present in the leaf of A. webbiana.…”

Section: Resultsmentioning

confidence: 99%

Isolation of flavonoid from Abies webbiana leaves and its activity

Yadav¹,

M²,

Ghosh³

et al. 2016

Phcogj

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Background: Abies webbiana commonly known as Talispatra in Bengali and Hindi, Talispatram in Sanskrit and Indian Silver Fir in English. This is a large, tall, evergreen tree occurring in the Himalayan region from Kashmir to Assam in India. It comes under the Family: Pinaceae. The present study was designed for isolation of flavonoid from ethyl acetate extract of A. webbiana leaves and assessed their toxic effect on liver and kidney. Materials and Methods: The isolation of flavonoid using different chroma tographic methods (thin layer and column chromatography). The isolated flavonoid was identified; Structures and chemical bonds were analyzed by using MP, FTIR, 1 H NMR and MS spectral analysis. Effect of flavonoid on liver and kidney was assessed by inducing (0.1 ml/kg) CCl 4 (i.p.) and (6 mg/kg) Cisplatin (i.p.) respectively measured by biochemical marker of liver and kidney. Results and Discussion: It was identified that isolated compound

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Section: Resultsmentioning

confidence: 99%

Isolation of flavonoid from Abies webbiana leaves and its activity

Yadav¹,

M²,

Ghosh³

et al. 2016

Phcogj

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“…Rice-Evans 25 considered flavonoids as ideal scavengers of peroxyl radicals and effective inhibitors of lipid peroxidation due to their favorable reduction potentials relatively to alkyl peroxyl radicals. Furthermore these compounds have the ability to interact with biomembranes, 37 occupying a favorable position to interrupt radical chain reactions. The results from the present study show that some 2-styrylchromones are as good ROO Å scavengers as the structurally similar flavonoids, or even better in some cases.…”

Section: Discussionmentioning

confidence: 99%

2-Styrylchromones: Novel strong scavengers of reactive oxygen and nitrogen species

Gomes

Fernandes

Silva

et al. 2007

Bioorganic & Medicinal Chemistry

129

173

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Abstract-2-Styrylchromones are a small group of naturally occurring chromones, vinylogues of flavones (2-phenylchromones). Natural and synthetic 2-styrylchromones have been tested in different biological systems, showing activities with potential therapeutic applications. In particular, the potential and hitherto understudied antioxidant behavior of these compounds has been raised as a matter of interest. Thus the present work consisted in the study of the in vitro scavenging activities for reactive oxygen species (ROS) and reactive nitrogen species (RNS) of various 2-styrylchromone derivatives and structurally similar flavonoids. Some of the studied 2-styrylchromones proved to be extremely efficient scavengers of the different ROS and RNS, showing, in some cases, IC 50 s under 1 lM. The hydroxylation pattern of 2-styrylchromones, especially in the B-ring but also in the A ring, modulates the activity of these compounds, the catecholic derivatives being the most effective scavengers. The styryl pattern also contributes to their observed outstanding antioxidant activity. In conclusion, the scavenging activities for ROS/RNS of 2-styrylchromone derivatives, here shown for the first time, provide novel and most promising compounds to be applied as antioxidants.

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“…Furthermore differences in the antioxidant abilities of quercetin and rutin in the inhibition of the autoxidation of rat cerebral membranes and iron-induced peroxidation of linoleic acid were concluded to be dictated by structural features and their propensity to interact and to penetrate lipid bilayers [26].…”

Section: Inhibition Of Ldl Oxidation By the Polyphenolsmentioning

confidence: 99%

Structural dependence of flavonoid interactions with Cu2+ ions: implications for their antioxidant properties

Brown

Khodr

Hider

et al. 1998

Biochemical Journal

736

389

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The flavonoids constitute a large group of polyphenolic phytochemicals with antioxidant properties in vitro. The interactions of four structurally related flavonoids (quercetin, kaempferol, rutin and luteolin) with Cu2+ ions were investigated in terms of the extent to which they undergo complex formation through chelation or modification through oxidation, as well as in their structural dependence. The ortho 3ʹ,4ʹ-dihydroxy substitution in the B ring is shown to be important for Cu2+-chelate formation, thereby influencing the antioxidant activity. The presence of a 3-hydroxy group in the flavonoid structure enhances the oxidation of quercetin and kaempferol, whereas luteolin and rutin, each lacking the 3-hydroxy group, do not oxidize as readily in the presence of Cu2+ ions. The results also demonstrate that the reactivities of the flavonoids in protecting low-density lipoprotein (LDL) against Cu2+ ion-induced oxidation are dependent on their structural properties in terms of the response of the particular flavonoid to Cu2+ ions, whether chelation or oxidation, their partitioning abilities between the aqueous compartment and the lipophilic environment within the LDL particle, and their hydrogen-donating antioxidant properties.

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Flavonoids as antioxidant agents: Importance of their interaction with biomembranes

Cited by 627 publications

References 29 publications

Isolation of flavonoid from Abies webbiana leaves and its activity

Isolation of flavonoid from Abies webbiana leaves and its activity

2-Styrylchromones: Novel strong scavengers of reactive oxygen and nitrogen species

Structural dependence of flavonoid interactions with Cu2+ ions: implications for their antioxidant properties

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