Flavonoids – Food Sources, Health Benefits, and Mechanisms Involved

Kozłowska, Aleksandra; Szostak-Węgierek, Dorota

doi:10.1007/978-3-319-54528-8_54-1

Cited by 87 publications

(100 citation statements)

References 108 publications

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“…Piceatannol is a hydroxylated analogue of resveratrol and shares the structural motif and biological activities, being even more potent in some studies [41]. Apart from the beneficial effects of stilbenes, the regular consumption of flavonoids is related to reduced risk of a number of chronic diseases, including cancer, cardiovascular disease and neurodegenerative disorders (reviewed in [42]). Flavonoids are divided into several groups, with flavonols being those containing the 3-hydroxy group, which has been considered very important for antioxidant activity.…”

Section: Discussionmentioning

confidence: 99%

Kaempferol increases levels of coenzyme Q in kidney cells and serves as a biosynthetic ring precursor

Fernández-del-Rio

Nag²,

Casado

et al. 2017

Free Radical Biology and Medicine

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Coenzyme Q (Q) is a lipid-soluble antioxidant essential in cellular physiology. Patients with Q deficiencies, with few exceptions, seldom respond to treatment. Current therapies rely on dietary supplementation with Q10, but due to its highly lipophilic nature, Q10 is difficult to absorb by tissues and cells. Plant polyphenols, present in the human diet, are redox active and modulate numerous cellular pathways. In the present study, we tested whether treatment with polyphenols affected the content or biosynthesis of Q. Mouse kidney proximal tubule epithelial (Tkpts) cells and human embryonic kidney cells 293 (HEK 293) were treated with several types of polyphenols, and kaempferol produced the largest increase in Q levels. Experiments with stable isotope 13C-labeled kaempferol demonstrated a previously unrecognized role of kaempferol as an aromatic ring precursor in Q biosynthesis. Investigations of the structure-function relationship of related flavonols showed the importance of two hydroxyl groups, located at C3 of the C ring and C4′ of the B ring, both present in kaempferol, as important determinants of kaempferol as a Q biosynthetic precursor. Concurrently, through a mechanism not related to the enhancement of Q biosynthesis, kaempferol also augmented mitochondrial localization of Sirt3. The role of kaempferol as a precursor that increases Q levels, combined with its ability to upregulate Sirt3, identify kaempferol as a potential candidate in the design of interventions aimed on increasing endogenous Q biosynthesis, particularly in kidney.

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Section: Discussionmentioning

confidence: 99%

Kaempferol increases levels of coenzyme Q in kidney cells and serves as a biosynthetic ring precursor

Fernández-del-Rio

Nag²,

Casado

et al. 2017

Free Radical Biology and Medicine

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“…Как бы там Обзоры и лекции ни было, сегодня имеются достаточно серьезные основания полагать, что многие флавоноиды оказывают протективное действие в отношении развития опухолей органов ротовой полости, желудка, двенадцатиперстной кишки, печени, легких, кожи, яичников, шейки матки, молочной и предстательной желез. При ýтом благоприятный ýффект, кроме кверцетина и других флавонолов, присущ флаван-3-олам, антоцианидинам, изофлавонам, флаванонам, флавонам и другим полифенольным соединениям растительного происхождения [14,16,[18][19][20][21][22][23][24][25].…”

Section: Conflict Of Interestunclassified

Antitumor activity of flavonoids

Зверев

2019

Bûll. sib. med.

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This review of the literature is devoted to the consideration of mechanisms of the antitumor effect of flavonoids. The anticanceromatous effect of flavonoids is discussed in the context of their impact on the main stages of development of malignant tumor cells. At the same time, the influence of flavonoids on the activity of protein kinases, metalloproteinases, apoptosis, angiogenesis and the cell cycle of tumor cells is considered in detail.

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“…Flavonoids are natural polyphenols present in fruits, vegetables, and plant‐derived products. Research in the past decade has demonstrated several health benefits of flavonoids (Kozłowska & Szostak‐Węgierek, ). The mechanisms underlying these health benefits include, but are not limited to, anti‐inflammation, antioxidation, antimicrobial, and antimutagenic effects (Bojić, Antolić, Tomičić, Debeljak, & Maleš, ).…”

Section: Introductionmentioning

confidence: 99%

Development and validation of a sensitive and specific LC–MS/MS cocktail assay for CYP450 enzymes: Application to study the effect of catechin on rat hepatic CYP activity

Nguyen

Espiritu

Elbarbry

2020

Biomedical Chromatography

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A sensitive and specific liquid chromatography tandem mass spectrometric (LC–MS/MS) method that enables the simultaneous quantification of probe substrates and metabolites of cytochrome P450 (CYP) enzymes was developed and validated. These substrates (metabolites)—coumarin (7‐hydroxycoumarin), tolbutamide (4‐hydroxytolbutamide), S‐mephenytoin (4‐hydroxymephenytoin), dextromethorphan (dextrorphan), and testosterone (6β‐hydroxytestosterone)—were utilized as markers for the activities of the major human CYP enzymes CYP2A6, CYP2C9, CYP2C19, CYP2D6, and CYP3A4, respectively. Analytes were separated on Kinetex C18 column (2.1 × 50 mm, 5 μm) using a binary gradient mobile phase of 0.1% formic acid in water and 0.1% formic acid in acetonitrile. Metabolites were detected and quantified by MS using multiple reaction monitoring at m/z 163 → 107.2 for 7‐hydroxycoumarin, m/z 235 → 150.1 for 4‐hydroxymephenytoin, m/z 287 → 171 for 4‐hydroxytolbutamide, m/z 258 → 157.1 for dextrorphan, m/z 305 → 269 for 6β‐hydroxytestosterone, and m/z 237 → 194 for the internal standard. The assay exhibited good linearity over a range of 10–500 ng/mL with acceptable accuracy and precision criteria. As a proof of concept, the developed cocktail assay was successfully used to examine the potential impact of catechin on the activity of the major rat liver CYP enzymes.

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Flavonoids – Food Sources, Health Benefits, and Mechanisms Involved

Cited by 87 publications

References 108 publications

Kaempferol increases levels of coenzyme Q in kidney cells and serves as a biosynthetic ring precursor

Kaempferol increases levels of coenzyme Q in kidney cells and serves as a biosynthetic ring precursor

Antitumor activity of flavonoids

Development and validation of a sensitive and specific LC–MS/MS cocktail assay for CYP450 enzymes: Application to study the effect of catechin on rat hepatic CYP activity

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