Flavonoids from Anemone tomentosa roots

Hu, Haobin; Zheng, Xiu-Ping; Yu-feng, Jian; Hu, Haifeng; Li, Y.; Zhang, Y. Q.

doi:10.1007/s10600-010-9697-z

Cited by 3 publications

(1 citation statement)

References 5 publications

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“…Differential regulation of two members of the LAR family was already found in apple when Liao et al [ 31 ] studied the expression of LAR1 and LAR2 in fruit skin at enlargement and mature stages. UFGT catalyzes the final glycosylation reaction in flavonoid biosynthesis and was associated with anthocyanin accumulation in several plant species [ 32 , 33 ]. Differential regulation of several members of the UFGT family was found in mango when expression analysis was performed on three genes ( MiUFGT1 , MiUFGT3 and MiUFGT4 ) in leaves, flowers, roots and fruits [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Isoenzymes of the Flavonoid and Phenylpropanoid Pathways Show Organ-Specific Regulation during Apple Fruit Development

Baldi,

Asquini,

Nicolussi Golo

et al. 2023

IJMS

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Elucidating the molecular mechanisms controlling fruit development is a primary target for the improvement of new apple (Malus × domestica Borkh.) cultivars. The first two weeks of development following pollination are crucial to determine fruit characteristics. During this period, a lot of changes take place in apple fruit, going from rapid cell division to the production of important metabolites. In this work, attention was focused on the phenylpropanoid and flavonoid pathways responsible for the production of numerous compounds contributing to fruit quality, such as flavonols, catechins, dihydrochalcones and anthocyanins. A total of 17 isoenzymes were identified, belonging to seven classes of the phenylpropanoid and flavonoid pathways that, despite showing more than 80% sequence identity, showed differential expression regulation during the first two weeks of apple fruit development. This feature seems to be quite common for most of the enzymes of both pathways. Differential regulation of isoenzymes was shown to be present in both ‘Golden Delicious’ and a wild relative (Malus mandshurica), even though differences were also present. Each isoenzyme showed a specific pattern of expression in the flower and fruit organs, suggesting that genes coding for enzymes with the same function may control different aspects of plant biology. Finally, promoter analysis was performed in order to highlight differences in the number and type of regulatory motifs. Overall, our results indicate that the control of the expression of genes involved in the phenylpropanoid and flavonoid pathways may be very complex as not only enzymes belonging to the same class, but even putative isoenzymes, can have different roles for the plant. Such genes may represent an important regulatory mechanism, as they would allow the plant to fine-tune the processing of metabolic intermediates towards different branches of the pathway, for example, in an organ-specific way.

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Section: Discussionmentioning

confidence: 99%

Isoenzymes of the Flavonoid and Phenylpropanoid Pathways Show Organ-Specific Regulation during Apple Fruit Development

Baldi,

Asquini,

Nicolussi Golo

et al. 2023

IJMS

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Triterpenoid saponins from the root of Anemone tomentosa

et al. 2012

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Three new triterpenoid saponins, tomentoside A (1), B (2) and C (3), along with four known saponins (4-7) were isolated from the root of Anemone tomentosa. The structures of the new compounds were elucidated as 3-O-β-D-ribopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→4)]-α-L-arabinopyranosyl hederagenin 28-O-α-L-rhamnopyranosyl-(1→4)-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside (1), 3-O-β-D-ribopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→4)]-β-D-xylopyranosyl hederagenin 28-O-α-L-rhamnopyranosyl-(1→4)-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside (2) and 3-O-β-D-galactopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→2)-β-D-xylopyranosyl oleanolic acid 28-O-α-L-rhamnopyranosyl-(1→4)-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside (3) on the basis of chemical and spectral evidence. In the oligosaccharide chains of compound 3, the characteristic D-galactose residue is a rare structural feature and secondly encountered among triterpenoid saponins from Anemone.

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Cytotoxic triterpenoid saponins from the root of Anemone tomentosa (Maxim.) Pei

Niu

Jia

et al. 2019

Natural Product Research

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Two new triterpenoid saponins (1-2), with eleven known compounds (3-13) were obtained from ethyl acetate extracts of Anemone tomentosa (Maxim.) Pei by bioactivity-guided isolation. Their structures were elucidated by chemical and spectral analysis, including 1D, 2D NMR data and HRESIMS. The cytotoxic activity of all isolated saponins was evaluated on MDA-MB-231 and PC-3 cell lines.Compounds 5 and 7 showed significant cytotoxicity against with MDA-MB-231 cell and PC-3 cell with IC 50 values of 3. 73-4.21 μM and 3.53-5.37 μM, respectively.

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Flavonoids from Anemone tomentosa roots

Cited by 3 publications

References 5 publications

Isoenzymes of the Flavonoid and Phenylpropanoid Pathways Show Organ-Specific Regulation during Apple Fruit Development

Isoenzymes of the Flavonoid and Phenylpropanoid Pathways Show Organ-Specific Regulation during Apple Fruit Development

Triterpenoid saponins from the root of Anemone tomentosa

Cytotoxic triterpenoid saponins from the root of Anemone tomentosa (Maxim.) Pei

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