Flavonoids from flower of linum capitatum kit

Ilić, Slavica V.; Konstantinović, Sandra S.; Todorović, Zoran B.

doi:10.2298/fupct0401067i

Cited by 6 publications

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References 2 publications

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“…Many researchers have investigated the antimicrobial activity of active compounds isolated from plants. Ilic et al [ 28 ] detected flavonoids from flowers of Linum capitatum using thin layer chromatography. Phenolic compounds were reported in the leaves of Cymbopogon citratus using TLC [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effects of leaf extract of Lawsonia inermis on Curvularia lunata and characterization of novel inhibitory compounds by GC–MS analysis

Barupal

Meena

Sharma

2019

Biotechnology Reports

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Section: Introductionmentioning

confidence: 99%

Inhibitory effects of leaf extract of Lawsonia inermis on Curvularia lunata and characterization of novel inhibitory compounds by GC–MS analysis

Barupal

Meena

Sharma

2019

Biotechnology Reports

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“…Only a few species from genus Linum are investigated for flavonoids [ 3,4 ]. In this genus, C-glycosylflavones were found only in the leaves of L. usitatissimum [ 4 ].…”

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confidence: 99%

Combined Control of the Bioprocess for Production of C-glycosylﬂavones from Linum thracicum in Bioreactor

Ionkov¹,

Sasheva²,

Йонкова³

et al. 2013

Proceeding BAS

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The high intake of foods and beverages rich in polyphenols, especially in flavonoids, has been associated with decreased risk of neoplasm. Luteolin shows therapeutic potential as a lead anticancer compound because it induces topoisomerase II-mediated apoptosis. The objective of this study is to develop cost-effective laboratory bio-technology for production of anticancer Cglycosylflavones. For the first time, callus and suspension cultures of Linum thracicum ssp. thracicum were initiated. The C-glycosylflavones were identified in plant and cell extracts on grounds of their characteristic LC-PDA-ESI-MS spectra and retention data in comparison with authentic reference samples. The main flavonoids were identified as an isoorientin (luteolin 6-C-glucoside) and isovitexin (apigenin 6-C-glucoside).Combining two fundamentally different control laws -the sliding nonlinear control and the linear controller, we are able to control a bioreactor in production of flavonoids in cell suspension of sensitive L. thracicum ssp. thracicum with a high concentration. After 24 days of sterile run cultivation of suspension in bioreactor, 22.8 g.l −1 dry wt of cell biomass was harvested from the bioreactor culture vessel, recording an increase of about 8 times over initial inoculum, with 2.47% ± 0.11 total flavonoids, which is with 1.18% ± 0.09 greater than yields from 300 ml flasks. Our findings are the first work on large cultivation of suspension of L. thracicum and bioreactor production of plant anticancer C-glycosylflavones. 139Key words: L. thracicum ssp. thracicum, in vitro cell cultures, Cglycosylflavones, stirred-tank bioreactor, combined bioreactor control Introduction. Flavonoids are phenolic substances isolated from a wide range of vascular plants. The role of dietary flavonoids in cancer prevention is widely discussed. They inhibit the proliferation of various cancer cells and tumour growth at nontoxic concentrations in organisms [ 1 ]. The high intake of foods and beverages rich in polyphenols, especially in flavonoids, has been associated with decreased risk of neoplasm. Chemoprevention has the potential to be a major component of colon, lung, prostate and bladder cancer control. These aspects made flavonoids an interesting object for industrial production. Luteolin shows therapeutic potential as a lead anti-cancer compound because it induces topoisomerase II-mediated apoptosis [ 5 ]. These aspects made luteolin and its glycosides an interesting object for pharmaceutical production.Different Linum species are shown to produce considerable amounts of lignans [ 2 ]. Only a few species from genus Linum are investigated for flavonoids [ 3,4 ]. In this genus, C-glycosylflavones were found only in the leaves of L. usitatissimum [ 4 ]. South-eastern Europe and the Balkan Peninsula in particular is a region rich in representatives of genus Linum, which could be a source of valuable molecules. Linum thracicum (Linaceae) -endemic species, native to the Balkan region, was not investigated in vitro up to now.For the first t...

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A Serbian Version of Modified and Revised Experiences in Close Relationships Scale (SM–ECR–R)

Hanak

Dimitrijević

2013

Journal of Personality Assessment

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We present details about the validation of the Serbian version of the Experiences in Close Relationships-Revised questionnaire modified to measure attachment in close relationships in general (SM-ECR-R). Its psychometric features were examined with 2 samples of students (N = 719 and N = 91) and 1 group of employed adults (N = 259). The results obtained in the student sample were equivalent to those obtained in validation studies worldwide, whereas in the more heterogeneous sample of employed adults, internal consistency of both avoidance and anxiety was lower and their intercorrelation was higher. Test-retest reliability was satisfactory, and relations with measures of attachment, empathy, and personality structure were meaningful. The results support the SM-ECR-R as a reliable and valid research instrument, but its internal structure and consistency might vary in different samples, depending on age, education, gender, and culture.

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Flavonoids from flower of linum capitatum kit

Cited by 6 publications

References 2 publications

Inhibitory effects of leaf extract of Lawsonia inermis on Curvularia lunata and characterization of novel inhibitory compounds by GC–MS analysis

Inhibitory effects of leaf extract of Lawsonia inermis on Curvularia lunata and characterization of novel inhibitory compounds by GC–MS analysis

Combined Control of the Bioprocess for Production of C-glycosylﬂavones from Linum thracicum in Bioreactor

A Serbian Version of Modified and Revised Experiences in Close Relationships Scale (SM–ECR–R)

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