Flavonoids from Friesodielsia discolor

Prawat, Uma; Phupornprasert, Duangraudee; Butsuri, Akkarapol; Salae, Abdul-Wahab; Boonsri, Sompong; Tuntiwachwuttikul, Pittaya

doi:10.1016/j.phytol.2012.09.007

Cited by 25 publications

(13 citation statements)

References 15 publications

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“…3). Flavanones such as nobiletin, tangeretin and liquiritigenin have been reported as the responsible active agents for the antibacterial activity of some medicinal plants [35][36][37]. The subsitutents significantly influence the antibacterial activity of flavanones.…”

Section: Flavanonementioning

confidence: 99%

Antibacterial Activities of Flavonoids: Structure-Activity Relationship and Mechanism

Fei¹,

Yang²,

Tang³

et al. 2014

CMC

605

369

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Flavonoids are well known as antibacterial agents against a wide range of pathogenic microorganism. With increasing prevalence of untreatable infections induced by antibiotic resistance bacteria, flavonoids have attracted much interest because of the potential to be substitutes for antibiotics. In this review, the structure-relationship of flavonoids as antibacterial agents is summarized, and the recent advancements on the antibacterial mechanisms of flavonoids are also discussed. It is concluded that hydroxyls at special sites on the aromatic rings of flavonoids improve the activity. However, the methylation of the active hydroxyl groups generally decreases the activity. Besides, the lipopholicity of the ring A is vital for the activity of chalcones. The hydrophobic substituents such as prenyl groups, alkylamino chains, alkyl chains, and nitrogen or oxygen containing heterocyclic moieties usually enhance the activity for all the flavonoids. The proposed antibacterial mechanisms of flavonoids are as follows: inhibition of nucleic acid synthesis, inhibition of cytoplasmic membrane function, inhibition of energy metabolism, inhibition of the attachment and biofilm formation, inhibition of the porin on the cell membrane, alteration of the membrane permeability, and attenuation of the pathogenicity.

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Section: Flavanonementioning

confidence: 99%

Antibacterial Activities of Flavonoids: Structure-Activity Relationship and Mechanism

Fei¹,

Yang²,

Tang³

et al. 2014

CMC

605

369

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“…Two plants in this family have been phytochemically investigated for their antiplasmodial and cytotoxic activities. From the leaves of Friesodielsia discolor, Prawat et al isolated two new flavonoids, 3'-formyl-2', 4'-dihydroxy-6'-methoxychalcone (5), 8-formyl-7-hydroxy-5-methoxyflava-none (6), and the known tectochrysin (7) (Figure 3) [31]. They displayed antiplasmodial activity against the K1 multidrug resistant strain of P. falciparum with IC50 values of 9.2, 9.3 and 7.8 μM, respectively.…”

Section: Annonaceaementioning

confidence: 99%

Antimalarial Activity of Plant Metabolites

Pan¹,

Xu²,

Shi³

et al. 2018

Preprint

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Malaria, as a major global health problem, continues to affect a large number of people each year, especially those in the developing countries. Effective drug discovery is still one of the main efforts to control malaria. As natural products are still considered as a key source for discovery and development of therapeutic agents, we have evaluated more than 2,000 plant extracts against Plasmodium falciparum. As a result, we discovered dozens of plant leads that displayed antimalarial activity. Our phytochemical study of some of these plant extracts led to identification of several potent antimalarial compounds. The prior comprehensive review article entitled "Antimalarial activity of plant metabolites" by Schwikkard and Van Heerden (2002) reported structures of plant-derived compounds with antiplasmodial activity and covered literature up to the year 2000. As a continuation of this effort, the present review covers the antimalarial compounds isolated from plants, including marine plants, reported in the literatures from 2001 to the end of 2017. During the span of the last 17 years, 175 antiplasmodial compounds were discovered from plants. These active compounds are organized in our review article according to their plant families. In addition, we also include ethnobotanical information of the antimalarial plants discussed.

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“…On the other hand, we had reported the isolation and identification of eleven phenolic compounds from Egyptian propolis for the first time; these compounds were pinostrobin, izalpinin, tectochrysin, pinocembrin, galangin, chrysin, quercetin-3,3'-di-O-methyl ether, kaempferol-3-O-methyl ether, quercetin-3,7-di-Omethyl ether, isoferulic acid and galangin-5-O-methyl ether (Ibrahim et al, 2014) In the present study, tectochrysin and quercetin-3,3'di-O-methylether, were tested for their anticancer activity on human breast cancer (MCF-7) and colorectal adenocarcinoma (Caco-2) cell lines. The choice of these two compounds was based on that there were no previous studies performed to assay their anticancer effect on MCF-7 or Caco-2 cell lines using neutral red uptake (NRU) method, except one study performed on tectochrysin isolated from Friesodielsia discolor which was tested for its cytotoxic activity on MCF-7 cell line and it exhibited cytotoxicity with IC 50 = 4.49 µg/ml, using the sulforhodamine B (SRB) assay (Prawat et al, 2012) Moreover, as several studies had revealed that ethanol extract of propolis samples collected abroad exhibited anticancer activity on MCF-7 (Kamiya et al, 2012;Xuan et al, 2014;Omene, 2013) and Caco-2 ( (Russo et al, 2004;Choudhari et al, 2013;Ishihara et al, 2009) cell lines, the present study is considered to be the first to screen the anticancer activity of Egyptian propolis against MCF-7 and Caco-2 cell lines.…”

Section: In-vitro Cytotoxic Activity Of Propolis Ethanol Extract Tecmentioning

confidence: 99%

Investigation of In-Vitro Cytotoxic and Potential Anticancer Activities of Flavonoidal Aglycones from Egyptian Propolis

Ibrahim

El-Din

Abu‐Serie

et al. 2018

Records of Pharmaceutical and Biomedical Sciences

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The in-vitro anticancer activity of Egyptian propolis ethanol extract as well as two isolated flavonoidal aglycones, tectochrysin and quercetin-3,3'-di-O-methylether,was assayed using neutral red uptake method on human breast cancer (MCF-7) and colorectal adenocarcinoma (Caco-2) cell lines, in addition to their in-vitro cytotoxic effect to normal human peripheral blood mononuclear cells (PBMCs). Egyptian propolis ethanol extract and quercetin-3,3'-di-O-methylether showed both high activity and selectivity towards the two tested cell lines suggesting them as effective, safe and selective anticancer candidates against both breast and colorectal cancer.

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Flavonoids from Friesodielsia discolor

Cited by 25 publications

References 15 publications

Antibacterial Activities of Flavonoids: Structure-Activity Relationship and Mechanism

Antibacterial Activities of Flavonoids: Structure-Activity Relationship and Mechanism

Antimalarial Activity of Plant Metabolites

Investigation of In-Vitro Cytotoxic and Potential Anticancer Activities of Flavonoidal Aglycones from Egyptian Propolis

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