Flavonoids from<i>Artemisia copa</i>with Anti-Inflammatory Activity

Moscatelli, Valeria; Hnatyszyn, O.; Acevedo, Cristina; Megías, Javier; Alcaraz, Marı́a José; Ferraro, Graciela

doi:10.1055/s-2005-873177

Cited by 68 publications

(46 citation statements)

References 8 publications

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“…Luteolin (compound 1) has been found to possess antiradical/antioxidative activity, especially when studied in cell-free systems 29 , as a glycolytic inhibitor might be a new adjuvant agent for chemotherapy 30 , possess antiinflammatory 31 , antiespasmodic 32 and antimicrobial activity 33 . Axilarin (compound 2) was reported in Artemisia copa and show antiinflammatory and antioxidant effect as well as inhibition on aldolase activity [34][35][36] . The compounds 3 and 4 have been previously found in other plant species 37,38 but its biological activity was not reported.…”

Section: Resultsmentioning

confidence: 99%

ANTIMICROBIAL AND ANTIOXIDANT COMPOUNDS FROM THE INFUSION AND METHANOLIC EXTRACT OF Baccharis incarum (WEDD.) PERKINS

Zampini

Isla

Schmeda‐Hirschmann

2009

J. Chil. Chem. Soc.

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In the traditional medicine of the South American highlands, the infusion and decoction of aerial parts of "tola", Baccharis incarum (Wedd.) Perkins (Asteraceae) is orally taken as an antiseptic, antipyretic and digestive or externally applied to relieve pain and inflammation.A plant infusion and methanolic (MeOH) extract of the aerial parts were compared for main constituents by HPLC-MS as well as assessed for antimicrobial and free radical scavenging activities. Assay-guided fractionation of the polar extracts was carried out using the ABTS•+ autographic as well as methicillin-resistant Staphylococcus aureus and Enterococcus faecalis bioautographic test. Seven compounds were isolated from the polar extracts and identified as chlorogenic acid, 3',4',5,7-tetrahydroxyflavone; dicaffeoyl quinic acid; 3',4',5,7-tetrahydroxy-3,6-dimethoxyflavone; 3',4 ',5,7-tetrahydroxy-3,6,8-trimethoxy flavone, 4',5,7-trihydroxy-3',3,6,8-tetramethoxyflavone and 4',5-dihydroxy-3',3,6,7,8-pentamethoxyflavone. The main constituents from the methanol extract and infusion were caffeic acid derivatives. This is the first report on the constituents of B. incarum infusion and show clear differences with previous phytochemical studies on the same plant. All isolated compounds showed antioxidant activity with SC 50 values of 1 to 10 µg/ml. The isolated flavones were active against methicillin-resistant Staphylococcus aureus and Enterococcus faecalis with MICs in the range 100 and >200 µg/ml.

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Section: Resultsmentioning

confidence: 99%

ANTIMICROBIAL AND ANTIOXIDANT COMPOUNDS FROM THE INFUSION AND METHANOLIC EXTRACT OF Baccharis incarum (WEDD.) PERKINS

Zampini

Isla

Schmeda‐Hirschmann

2009

J. Chil. Chem. Soc.

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“…The edema inhibition by compound 1 and 3 was maximum and it was more pronounced at the second phase, suggesting its inhibitory effect on prostaglandin production as a major mechanism by which compounds exert anti-inflammatory effect. Moscatelli et al [16] have studied the in vitro antiinflammatory activity of tricin, based on prostaglandin E 2 levels, cyclooxygenase (COX) and phospholipase activity. Chang et al [17] mention about the anti-inflammatory effect of salcolin B (identical with tricin 4′-O-(erythro-β-guaiacylglyceryl) ether) only, based on inhibition of nitric oxide (NO) in a cell line of mouse macrophages (RAW 264.7).…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Isolation, Characterization and Quantification of Tricin and Flavonolignans in the Medicinal Rice Njavara (Oryza sativa L.), as Compared to Staple Varieties

Mohanlal

Parvathy

Shalini

et al. 2011

Plant Foods Hum Nutr

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Njavara is an important medicinal rice variety of Kerala, India, widely used in Ayurveda as a 'health food' and in the treatment of rheumatoid arthritis, paralysis, neurodegenerative diseases and in rejuvenation therapy. Phytochemical investigations and spectroscopic studies of the diethyl ether fraction of methanolic extract of Njavara Black (NB) rice bran gave three important compounds namely, tricin and two rare flavonolignans- tricin 4'-O-(erythro-β-guaiacylglyceryl) ether and tricin 4'-O-(threo-β-guaiacylglyceryl) ether. The EC(50) values of these compounds in DPPH system were 90.39, 352.04 and 208.1 μg/ml, respectively. Quantification of the compounds by HPLC in NB and staple, non-medicinal rice varieties Sujatha (SJ) and Palakkadan Matta (PM) showed that tricin is present 39.64 and 16.12 fold higher in NB, compared to SJ and PM, respectively. This is the first report on the occurrence of tricin at significantly higher levels in Njavara and occurrence of the two flavonolignans in Oryza sativa species. Of the three compounds, tricin and the threo- form of flavonolignan showed anti-inflammatory effect of >65% after 5 h, at 2 mg/kg, in carrageenan-induced, paw edema experiments in rats. The results of the study corroborate with the preferential use of Njavara in indigenous medicine, over staple varieties.

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“…It is of interest that in spite of the substantial inhibition of viral replication and degree of CPE, the percentage of viable cells in the presence of tricin was unaltered when compared with untreated control cultures. It is known that tricin exhibits antiviral, antioxidant, antitumor and anti-inflammatory properties [33][34][35][36][37]. Some herbal medicines are useful in the treatment of AIDS patients in whom opportunistic HCMV infection is very common and also tends to become severe.…”

Section: Discussionmentioning

confidence: 99%

Anti-Human Cytomegalovirus Activity of Constituents from Sasa Albo-Marginata (Kumazasa in Japan)

Sakai

Watanabe

Koketsu

et al. 2008

Antivir Chem Chemother

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Background: Effective new anti-human cytomegalovirus (HCMV) agents and regimens need to be developed. We examined the anti-HCMV properties of crude extract (True World Extract of Bambuseae sasa [TWEBS]) and five compounds (p-coumaric acid, 3-hydroxy-4-methoxyben-zaldehyde [vanillin], p-hydroxybenzaldehyde, 3-hydroxypyridine and 4',5,7-trihydroxy-3',5'-dimethoxyflavone [tricin]), isolated from Sasa albo-marginata, a bamboo known in Japan as Sasa. Methods: Among TWEBS and five compounds screened in a plaque reduction assay, four showed anti-HCMV activity in the MRC-5 human embryonic fibroblast cell line. The anti-HCMV mechanisms of the TWEBS was examined by western blot analysis using primary antibody specific for an immediate early (IE) antigen of HCMV, for a structural late antigen of HCMV and for β-actin. Results: Treatment of cells with ⩾0.001% of TWEBS inhibited the observable cytopathic effects of HCMV on infected cells. Western blot analysis demonstrated that TWEBS decreased the expression of IE antigen and late antigen of HCMV in the infected cells. Next, we examined the anti-HCMV properties of five compounds isolated from TWEBS. In a viral plaque reduction assay, tricin showed dose-dependent inhibitory properties with a 50% effective concentration of 0.17 µug/ml (selective index =1,205.8). Conclusions: The hot water extract (TWEBS) of Sasa albo-marginata, with tricin isolated from it, has anti-HCMV activity in MRC-5 cells. TWEBS and/or tricin are a novel compound with potential anti-HCMV activity. Future studies should evaluate these findings in vivo.

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Flavonoids fromArtemisia copawith Anti-Inflammatory Activity

Cited by 68 publications

References 8 publications

ANTIMICROBIAL AND ANTIOXIDANT COMPOUNDS FROM THE INFUSION AND METHANOLIC EXTRACT OF Baccharis incarum (WEDD.) PERKINS

ANTIMICROBIAL AND ANTIOXIDANT COMPOUNDS FROM THE INFUSION AND METHANOLIC EXTRACT OF Baccharis incarum (WEDD.) PERKINS

Isolation, Characterization and Quantification of Tricin and Flavonolignans in the Medicinal Rice Njavara (Oryza sativa L.), as Compared to Staple Varieties

Anti-Human Cytomegalovirus Activity of Constituents from Sasa Albo-Marginata (Kumazasa in Japan)

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